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anti-Integral Membrane Protein 2B (ITM2B) Antibodies

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. Additionally we are shipping Integral Membrane Protein 2B Proteins (18) and Integral Membrane Protein 2B Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ITM2B 9445 Q9Y287
ITM2B 16432 O89051
ITM2B 290364 Q5XIE8
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Top anti-Integral Membrane Protein 2B Antibodies at antibodies-online.com

Showing 10 out of 57 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Chicken Un-conjugated IHC (fro), WB Figure 1. Western Blot of various organs stained with anti BRI (ITM2B)... 0.2 mg Log in to see 6 to 8 Days
$621.50
Details
Human Mouse Un-conjugated FACS, IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane... Flow cytometric Analysis of Hela cells, using anti-ITM2B antibody (ABI... 100 μL Log in to see 2 to 3 Days
$482.90
Details
Human Chicken Un-conjugated IHC (fro)   0.2 mg Log in to see 6 to 8 Days
$577.50
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Anti-ITM2B antibody IHC staining of human small intestine, myenteric p... 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Chicken Un-conjugated WB 0.05 mg Log in to see 2 to 3 Days
$412.50
Details
Human Mouse Un-conjugated FACS, IHC (p), WB 100 μL Log in to see 8 to 10 Days
$529.83
Details
Mouse Rabbit Un-conjugated IHC (p), WB ITM2B Antibody (C-term) (ABIN657087) western blot analysis in mouse ce... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Rabbit Un-conjugated IHC, WB 400 μL Log in to see 6 Days
$457.14
Details

ITM2B Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
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Mouse (Murine) , , , ,
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Rat (Rattus) , , , ,
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Top referenced anti-Integral Membrane Protein 2B Antibodies

  1. Human Polyclonal ITM2B Primary Antibody for IHC (fro) - ABIN113338 : Vidal, Frangione, Rostagno, Mead, Révész, Plant, Ghiso: A stop-codon mutation in the BRI gene associated with familial British dementia. in Nature 1999 (PubMed)

  2. Cow (Bovine) Polyclonal ITM2B Primary Antibody for WB - ABIN375095 : Majewski, Lee, Jeong, Yoon, Kram, Kim, Tuziak, Bondaruk, Lee, Park, Tang, Chung, Shen, Ahmed, Johnston, Grossman, Dinney, Zhou, Harris, Snyder, Filipek, Narod, Watson, Lynch, Gazdar, Bar-Eli, Wu, McConkey, Baggerly, Issa, Benedict, Scherer, Czerniak: Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy. in Laboratory investigation; a journal of technical methods and pathology 2008 (PubMed)

More Antibodies against Integral Membrane Protein 2B Interaction Partners

Human Integral Membrane Protein 2B (ITM2B) interaction partners

  1. Cystine-linked oligomers of ABri are toxic to neurons and block long-term potentiation.

  2. Data indicate integral membrane 2B (ITM2B) as a target of B-cell CLL/lymphoma 6 (show BCL6 Antibodies) protein (BCL6 (show BCL6 Antibodies)) repression in lymphoma.

  3. Data indicate that the mutation originates the highly amyloidogenic molecule integral membrane protein 2B ABri.

  4. This review support the hypothesis that BRI2 change during disease devel-opment, and thus may have a role in Alzheimer disease.

  5. It binds amyloid precursor protein (show APP Antibodies) to halt amyloid-b production and inhibits amyloid-b aggregation via its BRICHOS-domain suggesting a link between BRI2 and Alzheimer's disease (AD)

  6. Findings highlight pathogenic mechanism(s) associated with ITM2B mutations underlying dementia or retinal disease and add a new candidate to the list of genes involved in inherited retinal dystrophies.

  7. Structural modeling of transmembrane (BRICHOS) domains of BRI2/ITM2B and SFTPC (show SFTPC Antibodies) (pulmonary surfactant protein C (show SFTPC Antibodies)) precursor identifies conserved region structurally complementary to beta-sheet/amyloid-prone region in BRICHOS domain-containing proteins.

  8. These results suggest that BRI2 may prevent access of BACE1 (show BACE Antibodies) to APP (show APP Antibodies) and the BRI2/BACE1 (show BACE Antibodies) interaction may mediate the reduction in BACE1 (show BACE Antibodies) levels.

  9. Similarities of ABri and ADan to Abeta (show APP Antibodies) in Alzheimer's disease suggest that posttranslational pGlu-modification of amyloid peptides might represent general pathological mechanism leading to increased aggregation and toxicity forms of degenerative dementias.

  10. Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin (show SYP Antibodies) levels.

Mouse (Murine) Integral Membrane Protein 2B (ITM2B) interaction partners

  1. Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin (show SYP Antibodies) levels.

  2. BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE (show IDE Antibodies)).

  3. Suggest that Adam7 (show ADAM7 Antibodies) functions in fertilization through the formation of a complex with heat shock protein 5 (show HSPA5 Antibodies), calnexin (show CANX Antibodies) and Itm2b during capacitation in sperm.

  4. The shor form of ITM2B induces apoptosis in IL-2 (show IL2 Antibodies)-stimulated cells. The long form can't induce it. ITM2B(s) interacts with Bcl-2 (show BCL2 Antibodies), but not with Bad. Mutation of the L and D residues in the BH3 domain abolished the ability of ITM2B(s) to promote apoptosis.

  5. ITM2B(S) induces apoptosis via a caspase (show CASP3 Antibodies)-dependent mitochondrial pathway.

  6. BH3-only (show BBC3 Antibodies) protein ITM2Bs is able to induce apoptotic cell death in p53 (show TP53 Antibodies)+/+, as well as in p53 (show TP53 Antibodies)-/- cell lines.

  7. Itm2b mRNA was differentially expressed in mouse male reproductive tissues, during sexual maturation and up-regulated by testosterone.

Integral Membrane Protein 2B (ITM2B) Antigen Profile

Protein Summary

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Gene names and symbols associated with ITM2B

  • integral membrane protein 2Ba (itm2ba) antibody
  • integral membrane protein 2B (itm2b) antibody
  • integral membrane protein 2B (ITM2B) antibody
  • integral membrane protein 2b (itm2b) antibody
  • integral membrane protein 2B (Itm2b) antibody
  • ABRI antibody
  • AI256040 antibody
  • BRI antibody
  • Bri2 antibody
  • Bricd2b antibody
  • D14Sel6 antibody
  • E3-16 antibody
  • E25B antibody
  • E25BMM antibody
  • FBD antibody
  • imBRI2 antibody
  • ITM2B antibody
  • MGC52745 antibody
  • MGC76131 antibody
  • wu:fc05f02 antibody
  • zgc:55770 antibody
  • zgc:85688 antibody

Protein level used designations for ITM2B

integral membrane protein 2B , immature BRI2 , transmembrane protein BRI , integral membrane protein 2b , ABri/ADan amyloid peptide , BRICHOS domain containing 2B , Integral membrane protein 2B (E25B protein) , putative transmembrane protein E3-16 , transmembrane protein E3-16 , BRICHOS-like protein

GENE ID SPECIES
323632 Danio rerio
380074 Xenopus laevis
394850 Xenopus (Silurana) tropicalis
476916 Canis lupus familiaris
100173146 Pongo abelii
100174988 Ovis aries
100528504 Ictalurus punctatus
9445 Homo sapiens
510575 Bos taurus
16432 Mus musculus
290364 Rattus norvegicus
395969 Gallus gallus
595120 Sus scrofa
452714 Pan troglodytes
100459693 Pongo abelii
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