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Integral Membrane Protein 2B Proteins (ITM2B)

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. Additionally we are shipping Integral Membrane Protein 2B Antibodies (59) and Integral Membrane Protein 2B Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ITM2B 9445 Q9Y287
ITM2B 16432 O89051
ITM2B 290364 Q5XIE8
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Top Integral Membrane Protein 2B Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,016.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,031.33
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,031.33
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,031.33
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,031.33
Details

ITM2B Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Integral Membrane Protein 2B (ITM2B) Interaction Partners

Human Integral Membrane Protein 2B (ITM2B) interaction partners

  1. when BRI2 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident

  2. Data depict roles for Bri2 and apolipoprotein E4 (ApoE4) proteins in a long-term memory regulation pathway. A single mutation in one Itm2b/Bri2 allele can affect both long-term and working memory, while ApoE4 seems to regulate short-term/working memory.

  3. Cystine-linked oligomers of ABri are toxic to neurons and block long-term potentiation.

  4. Data indicate integral membrane 2B (ITM2B) as a target of B-cell CLL/lymphoma 6 (show BCL6 Proteins) protein (BCL6 (show BCL6 Proteins)) repression in lymphoma.

  5. Data indicate that the mutation originates the highly amyloidogenic molecule integral membrane protein 2B ABri.

  6. This review support the hypothesis that BRI2 change during disease devel-opment, and thus may have a role in Alzheimer disease.

  7. It binds amyloid precursor protein (show APP Proteins) to halt amyloid-b production and inhibits amyloid-b aggregation via its BRICHOS-domain suggesting a link between BRI2 and Alzheimer's disease (AD)

  8. Findings highlight pathogenic mechanism(s) associated with ITM2B mutations underlying dementia or retinal disease and add a new candidate to the list of genes involved in inherited retinal dystrophies.

  9. Structural modeling of transmembrane (BRICHOS) domains of BRI2/ITM2B and SFTPC (show SFTPC Proteins) (pulmonary surfactant protein C (show SFTPC Proteins)) precursor identifies conserved region structurally complementary to beta-sheet/amyloid-prone region in BRICHOS domain-containing proteins.

  10. These results suggest that BRI2 may prevent access of BACE1 (show BACE Proteins) to APP (show APP Proteins) and the BRI2/BACE1 (show BACE Proteins) interaction may mediate the reduction in BACE1 (show BACE Proteins) levels.

Mouse (Murine) Integral Membrane Protein 2B (ITM2B) interaction partners

  1. Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin (show SYP Proteins) levels.

  2. BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE (show IDE Proteins)).

  3. Suggest that Adam7 (show ADAM7 Proteins) functions in fertilization through the formation of a complex with heat shock protein 5 (show HSPA5 Proteins), calnexin (show CANX Proteins) and Itm2b during capacitation in sperm.

  4. The shor form of ITM2B induces apoptosis in IL-2 (show IL2 Proteins)-stimulated cells. The long form can't induce it. ITM2B(s) interacts with Bcl-2 (show BCL2 Proteins), but not with Bad. Mutation of the L and D residues in the BH3 domain abolished the ability of ITM2B(s) to promote apoptosis.

  5. ITM2B(S) induces apoptosis via a caspase (show CASP3 Proteins)-dependent mitochondrial pathway.

  6. BH3-only (show BBC3 Proteins) protein ITM2Bs is able to induce apoptotic cell death in p53 (show TP53 Proteins)+/+, as well as in p53 (show TP53 Proteins)-/- cell lines.

  7. Itm2b mRNA was differentially expressed in mouse male reproductive tissues, during sexual maturation and up-regulated by testosterone.

Integral Membrane Protein 2B (ITM2B) Protein Profile

Protein Summary

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Gene names and symbols associated with ITM2B

  • integral membrane protein 2Ba (itm2ba)
  • integral membrane protein 2B (itm2b)
  • integral membrane protein 2B (ITM2B)
  • integral membrane protein 2b (itm2b)
  • integral membrane protein 2B (Itm2b)
  • ABRI protein
  • AI256040 protein
  • BRI protein
  • Bri2 protein
  • Bricd2b protein
  • D14Sel6 protein
  • E3-16 protein
  • E25B protein
  • E25BMM protein
  • FBD protein
  • imBRI2 protein
  • ITM2B protein
  • MGC52745 protein
  • MGC76131 protein
  • wu:fc05f02 protein
  • zgc:55770 protein
  • zgc:85688 protein

Protein level used designations for ITM2B

integral membrane protein 2B , immature BRI2 , transmembrane protein BRI , integral membrane protein 2b , ABri/ADan amyloid peptide , BRICHOS domain containing 2B , Integral membrane protein 2B (E25B protein) , putative transmembrane protein E3-16 , transmembrane protein E3-16 , BRICHOS-like protein

GENE ID SPECIES
323632 Danio rerio
380074 Xenopus laevis
394850 Xenopus (Silurana) tropicalis
476916 Canis lupus familiaris
100173146 Pongo abelii
100174988 Ovis aries
100528504 Ictalurus punctatus
9445 Homo sapiens
510575 Bos taurus
16432 Mus musculus
290364 Rattus norvegicus
395969 Gallus gallus
595120 Sus scrofa
452714 Pan troglodytes
100459693 Pongo abelii
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