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Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. Additionally we are shipping Integral Membrane Protein 2B Proteins (19) and Integral Membrane Protein 2B Kits (1) and many more products for this protein.
Showing 10 out of 62 products:
Human Polyclonal ITM2B Primary Antibody for IHC (fro) - ABIN113338
Vidal, Frangione, Rostagno, Mead, Révész, Plant, Ghiso: A stop-codon mutation in the BRI gene associated with familial British dementia. in Nature 1999
Cow (Bovine) Polyclonal ITM2B Primary Antibody for WB - ABIN375095
Majewski, Lee, Jeong, Yoon, Kram, Kim, Tuziak, Bondaruk, Lee, Park, Tang, Chung, Shen, Ahmed, Johnston, Grossman, Dinney, Zhou, Harris, Snyder, Filipek, Narod, Watson, Lynch, Gazdar, Bar-Eli, Wu et al.: Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy. ... in Laboratory investigation; a journal of technical methods and pathology 2008
Human Polyclonal ITM2B Primary Antibody for ICC, IF - ABIN4327783
Baron, Baron, Baron: The ITM2B (BRI2) gene is a target of BCL6 repression: Implications for lymphomas and neurodegenerative diseases. in Biochimica et biophysica acta 2015
when BRI2 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident
Data depict roles for Bri2 and apolipoprotein E4 (ApoE4) proteins in a long-term memory regulation pathway. A single mutation in one Itm2b/Bri2 allele can affect both long-term and working memory, while ApoE4 seems to regulate short-term/working memory.
Cystine-linked oligomers of ABri are toxic to neurons and block long-term potentiation.
Data indicate integral membrane 2B (ITM2B) as a target of B-cell CLL/lymphoma 6 (show BCL6 Antibodies) protein (BCL6 (show BCL6 Antibodies)) repression in lymphoma.
Data indicate that the mutation originates the highly amyloidogenic molecule integral membrane protein 2B ABri.
This review support the hypothesis that BRI2 change during disease devel-opment, and thus may have a role in Alzheimer disease.
It binds amyloid precursor protein (show APP Antibodies) to halt amyloid-b production and inhibits amyloid-b aggregation via its BRICHOS-domain suggesting a link between BRI2 and Alzheimer's disease (AD)
Findings highlight pathogenic mechanism(s) associated with ITM2B mutations underlying dementia or retinal disease and add a new candidate to the list of genes involved in inherited retinal dystrophies.
Structural modeling of transmembrane (BRICHOS) domains of BRI2/ITM2B and SFTPC (show SFTPC Antibodies) (pulmonary surfactant protein C (show SFTPC Antibodies)) precursor identifies conserved region structurally complementary to beta-sheet/amyloid-prone region in BRICHOS domain-containing proteins.
These results suggest that BRI2 may prevent access of BACE1 (show BACE Antibodies) to APP (show APP Antibodies) and the BRI2/BACE1 (show BACE Antibodies) interaction may mediate the reduction in BACE1 (show BACE Antibodies) levels.
Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin (show SYP Antibodies) levels.
BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE (show IDE Antibodies)).
Suggest that Adam7 (show ADAM7 Antibodies) functions in fertilization through the formation of a complex with heat shock protein 5 (show HSPA5 Antibodies), calnexin (show CANX Antibodies) and Itm2b during capacitation in sperm.
The shor form of ITM2B induces apoptosis in IL-2 (show IL2 Antibodies)-stimulated cells. The long form can't induce it. ITM2B(s) interacts with Bcl-2 (show BCL2 Antibodies), but not with Bad. Mutation of the L and D residues in the BH3 domain abolished the ability of ITM2B(s) to promote apoptosis.
ITM2B(S) induces apoptosis via a caspase (show CASP3 Antibodies)-dependent mitochondrial pathway.
BH3-only (show BBC3 Antibodies) protein ITM2Bs is able to induce apoptotic cell death in p53 (show TP53 Antibodies)+/+, as well as in p53 (show TP53 Antibodies)-/- cell lines.
Itm2b mRNA was differentially expressed in mouse male reproductive tissues, during sexual maturation and up-regulated by testosterone.
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
integral membrane protein 2B
, immature BRI2
, transmembrane protein BRI
, integral membrane protein 2b
, ABri/ADan amyloid peptide
, BRICHOS domain containing 2B
, Integral membrane protein 2B (E25B protein)
, putative transmembrane protein E3-16
, transmembrane protein E3-16
, BRICHOS-like protein