Integral Membrane Protein 2B (ITM2B) ELISA Kits

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. Additionally we are shipping Integral Membrane Protein 2B Antibodies (63) and Integral Membrane Protein 2B Proteins (19) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
ITM2B 9445 Q9Y287
Anti-Mouse ITM2B ITM2B 16432 O89051
Anti-Rat ITM2B ITM2B 290364 Q5XIE8
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More ELISA Kits for Integral Membrane Protein 2B Interaction Partners

Human Integral Membrane Protein 2B (ITM2B) interaction partners

  1. when BRI2 is phosphorylated a significant increase in neuronal outgrowth and differentiation is evident

  2. Data depict roles for Bri2 and apolipoprotein E4 (ApoE4) proteins in a long-term memory regulation pathway. A single mutation in one Itm2b/Bri2 allele can affect both long-term and working memory, while ApoE4 seems to regulate short-term/working memory.

  3. Cystine-linked oligomers of ABri are toxic to neurons and block long-term potentiation.

  4. Data indicate integral membrane 2B (ITM2B) as a target of B-cell CLL/lymphoma 6 (show BCL6 ELISA Kits) protein (BCL6 (show BCL6 ELISA Kits)) repression in lymphoma.

  5. Data indicate that the mutation originates the highly amyloidogenic molecule integral membrane protein 2B ABri.

  6. This review support the hypothesis that BRI2 change during disease devel-opment, and thus may have a role in Alzheimer disease.

  7. It binds amyloid precursor protein (show APP ELISA Kits) to halt amyloid-b production and inhibits amyloid-b aggregation via its BRICHOS-domain suggesting a link between BRI2 and Alzheimer's disease (AD)

  8. Findings highlight pathogenic mechanism(s) associated with ITM2B mutations underlying dementia or retinal disease and add a new candidate to the list of genes involved in inherited retinal dystrophies.

  9. Structural modeling of transmembrane (BRICHOS) domains of BRI2/ITM2B and SFTPC (show SFTPC ELISA Kits) (pulmonary surfactant protein C (show SFTPC ELISA Kits)) precursor identifies conserved region structurally complementary to beta-sheet/amyloid-prone region in BRICHOS domain-containing proteins.

  10. These results suggest that BRI2 may prevent access of BACE1 (show BACE ELISA Kits) to APP (show APP ELISA Kits) and the BRI2/BACE1 (show BACE ELISA Kits) interaction may mediate the reduction in BACE1 (show BACE ELISA Kits) levels.

Mouse (Murine) Integral Membrane Protein 2B (ITM2B) interaction partners

  1. Data indicate that double transgenic (Tg-FDD-Tau) mice showed a significant decrease in synaptophysin (show SYP ELISA Kits) levels.

  2. BRI2 protein regulates beta-amyloid degradation by increasing levels of secreted insulin-degrading enzyme (IDE (show IDE ELISA Kits)).

  3. Suggest that Adam7 (show ADAM7 ELISA Kits) functions in fertilization through the formation of a complex with heat shock protein 5 (show HSPA5 ELISA Kits), calnexin (show CANX ELISA Kits) and Itm2b during capacitation in sperm.

  4. The shor form of ITM2B induces apoptosis in IL-2 (show IL2 ELISA Kits)-stimulated cells. The long form can't induce it. ITM2B(s) interacts with Bcl-2 (show BCL2 ELISA Kits), but not with Bad. Mutation of the L and D residues in the BH3 domain abolished the ability of ITM2B(s) to promote apoptosis.

  5. ITM2B(S) induces apoptosis via a caspase (show CASP3 ELISA Kits)-dependent mitochondrial pathway.

  6. BH3-only (show BBC3 ELISA Kits) protein ITM2Bs is able to induce apoptotic cell death in p53 (show TP53 ELISA Kits)+/+, as well as in p53 (show TP53 ELISA Kits)-/- cell lines.

  7. Itm2b mRNA was differentially expressed in mouse male reproductive tissues, during sexual maturation and up-regulated by testosterone.

Integral Membrane Protein 2B (ITM2B) Antigen Profile

Antigen Summary

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

Gene names and symbols associated with ITM2B

  • integral membrane protein 2Ba (itm2ba) antibody
  • integral membrane protein 2B (itm2b) antibody
  • integral membrane protein 2B (ITM2B) antibody
  • integral membrane protein 2b (itm2b) antibody
  • integral membrane protein 2B (Itm2b) antibody
  • ABRI antibody
  • AI256040 antibody
  • BRI antibody
  • Bri2 antibody
  • Bricd2b antibody
  • D14Sel6 antibody
  • E3-16 antibody
  • E25B antibody
  • E25BMM antibody
  • FBD antibody
  • imBRI2 antibody
  • ITM2B antibody
  • MGC52745 antibody
  • MGC76131 antibody
  • wu:fc05f02 antibody
  • zgc:55770 antibody
  • zgc:85688 antibody

Protein level used designations for ITM2B

integral membrane protein 2B , immature BRI2 , transmembrane protein BRI , integral membrane protein 2b , ABri/ADan amyloid peptide , BRICHOS domain containing 2B , Integral membrane protein 2B (E25B protein) , putative transmembrane protein E3-16 , transmembrane protein E3-16 , BRICHOS-like protein

323632 Danio rerio
380074 Xenopus laevis
394850 Xenopus (Silurana) tropicalis
476916 Canis lupus familiaris
100173146 Pongo abelii
100174988 Ovis aries
100528504 Ictalurus punctatus
9445 Homo sapiens
510575 Bos taurus
16432 Mus musculus
290364 Rattus norvegicus
395969 Gallus gallus
595120 Sus scrofa
452714 Pan troglodytes
100459693 Pongo abelii
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