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anti-Integrin, alpha 2b (Platelet Glycoprotein IIb of IIb/IIIa Complex, Antigen CD41) (ITGA2B) Antibodies

ITGA2B encodes integrin alpha chain 2b. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Human ITGA2B ITGA2B 3674 P08514
Anti-Mouse ITGA2B ITGA2B 16399 Q9QUM0
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More Antibodies against ITGA2B Interaction Partners

Human Integrin, alpha 2b (Platelet Glycoprotein IIb of IIb/IIIa Complex, Antigen CD41) (ITGA2B) interaction partners

  1. Data show that immune thrombocytopenia (ITP (show ITPA Antibodies)) is an autoimmune bleeding disorder characterized by low platelet count and presence of IgG autoantibodies to platelet surface glycoproteins, such as alpha IIbbeta3 integrins.

  2. Data suggest that the ligand AGDV tetrapeptide binds to ITGB3/GPIIIa (show ITGB3 Antibodies) subunit and induces complete opening of headpiece of integrin alphaIIb/beta3 complex; AGDV appears to have very little contact with ITGA2B/GPIIb subunit.

  3. Analysis showed a protective effect of TT genotype of ITGA2 (show ITGA2 Antibodies) 807 C/T on fibrosis progression rate in Chronic Hepatitis C patients.

  4. Report novel ITGA2B mutations causing Glanzmann thrombasthenia.

  5. Ibrutinib causes GPVI (show GP6 Antibodies) and integrin alphaIIbbeta3 platelet signaling deficiencies that result in formation of unstable thrombi and may contribute toward bleeding.

  6. Data indicate 114 novel missense variants in integrin alpha 2b (ITGA2B) and 68 novel missense variants in integrin beta 3 (ITGB3 (show ITGB3 Antibodies)).

  7. Data (including data from molecular dynamic simulations) suggest specific interactions between glycoprotein GPIIb/GPIIIa (show ITGB3 Antibodies) complex transmembrane/C-terminal domains and talin-1 (show TLN1 Antibodies) in cell membrane environment during platelet activation.

  8. Anionic lipids in annular positions stabilize the alphaIIbbeta3 transmembrane complex by up to 0.50 +/- 0.02 kcal/mol (show DUOXA1 Antibodies) relative to zwitterionic lipids in a headgroup structure-dependent manner.

  9. ITGA2B rs5911 GG genotype is associated with decreased ex vivo antiplatelet activity of ticagrelor in healthy Chinese male subjects.

  10. The genetic polymorphism of GP lIb (show LRRC15 Antibodies)-Illa (GP Ila (show TNFRSF9 Antibodies) Leu33Pro) was not noted to affect platelet aggregation.

Mouse (Murine) Integrin, alpha 2b (Platelet Glycoprotein IIb of IIb/IIIa Complex, Antigen CD41) (ITGA2B) interaction partners

  1. ITGA2b expression increases in response to immunization, raising the possibility that heterogeneous ITGA2b levels reflect variation in exposure to activation signals.

  2. Thrombopoietin (show THPO Antibodies)/MPL (show MPL Antibodies) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 (show MECOM Antibodies) leukemia.

  3. Direct binding of kindlin-3 (show FERMT3 Antibodies) to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.

  4. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  5. reduction of talin-beta3 integrin (show ITGB3 Antibodies) binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding

  6. deficiency of Dok-2 leads to dysregulated integrin alphaIIbbeta3-dependent cytosolic calcium flux and phosphatidylinositol(3,4)P2 accumulation.

  7. Platelets lacking ERp57 (show PDIA3 Antibodies) have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57 (show PDIA3 Antibodies), implicating surface ERp57 (show PDIA3 Antibodies) in platelet aggregation.

  8. Data indicate that Pyk2 (show PTK2B Antibodies) is a common signaling effector downstream of both G12 (show TCF3 Antibodies)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.

  9. These results identify a novel pathway of integrin alphaIIbbeta3 outside-in signaling and recognize the tyrosine kinase Pyk2 as a major regulator of platelet adhesion and spreading on fibrinogen.

  10. identified Hic-5 (show TGFB1I1 Antibodies) as a novel and specific regulatory factor for thrombin (show F2 Antibodies)-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice.

ITGA2B Antigen Profile

Protein Summary

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Gene names and symbols associated with ITGA2B

  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (ITGA2B) antibody
  • integrin alpha 2b (Itga2b) antibody
  • AI172977 antibody
  • alphaIIb antibody
  • BDPLT2 antibody
  • BDPLT16 antibody
  • CD41 antibody
  • CD41B antibody
  • GP2B antibody
  • GpIIb antibody
  • GT antibody
  • GTA antibody
  • HPA3 antibody

Protein level used designations for ITGA2B

GPalpha IIb , integrin alpha-IIb , platelet fibrinogen receptor, alpha subunit , platelet membrane glycoprotein IIb , platelet-specific antigen BAK , GP IIb , alpha IIb , platelet glycoprotein IIb of IIb/II Ia complex

3674 Homo sapiens
16399 Mus musculus
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