anti-Integrin alpha 2b (ITGA2B) Antibodies

ITGA2B encodes integrin alpha chain 2b.

list all antibodies Gene Name GeneID UniProt
Anti-Human ITGA2B ITGA2B 3674 P08514
Anti-Mouse ITGA2B ITGA2B 16399 Q9QUM0
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More Antibodies against Integrin alpha 2b Interaction Partners

Human Integrin alpha 2b (ITGA2B) interaction partners

  1. Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 (show ITGA3 Antibodies) and ITGA2B), collagen ( COL5A1 (show COL5A1 Antibodies)), and laminin ( LAMA5 (show LAMA5 Antibodies)) were significantly inhibited by curcumin at messenger RNA and protein levels.

  2. Case Report: Reduced binding of mutant FLNa (show FLNA Antibodies) to beta3 and the facilitated recruitment of talin by beta3 on platelet stimulation, explaining the increased alphaIIbbeta3 activation and the ensuing gain-of-platelet functions.

  3. Mechanistic basis for the binding of fibrinogen-derived RGD- and AGDV-peptides to the platelet integrin alphaIIb-beta3 has been described.

  4. the contribution of PAR1 (show MARK2 Antibodies) and PAR4 (show PAWR Antibodies) to thrombin (show F2 Antibodies)-mediated activation of the platelet fibrin receptor (GPIIbIIIa), is reported.

  5. The most common HPA (show HPSE Antibodies) genotypes among Saudis were HPA-1 (show HPSE Antibodies) a + b- (75%), HPA-2 (show HPSE2 Antibodies) a + b- (62%), HPA-3 a + b- (51.5%), HPA (show HPSE Antibodies)-4 a + b- (99%), HPA-5 (show ITGA2 Antibodies) a + b- (76.5%), HPA (show HPSE Antibodies)-6 a + b- (100%) and HPA (show HPSE Antibodies)-15 a + b + (50%). The prevalent allele among the HPA (show HPSE Antibodies) systems was (a), except in the HPA (show HPSE Antibodies)-15 system where the (b) allele was found in 52% of the subjects.

  6. Integrin alpha-IIb beta-3 dependent ERK (show EPHB2 Antibodies) signaling is regulated by Src (show SRC Antibodies) and Rho kinases in both Leu33 and Pro33 polymorphic isoforms.

  7. Data suggest that CD41 and CD45 (show PTPRC Antibodies) expression marked the onset of haemangioblastoma (HB) neovascularisation and the stepwise development of the angioformative period, and also the underlying therapeutic targets of anti-vascular treatment.

  8. ITGA2B and ITGA8 have roles in prognosis in clear cell renal cell carcinoma (show MOK Antibodies) patients

  9. Thirteen variants in the ITGA2B locus and 29 variants in the ITGB3 (show ITGB3 Antibodies) locus were identified.

  10. This study shows correlation of blood clot (show TXNDC17 Antibodies) stiffness with platelet integrin alpha-IIb beta3 activity, aspirin usage, and transfusion risk in cardiopulmonary bypass patients.

Mouse (Murine) Integrin alpha 2b (ITGA2B) interaction partners

  1. ITGA2b expression increases in response to immunization, raising the possibility that heterogeneous ITGA2b levels reflect variation in exposure to activation signals.

  2. Thrombopoietin (show THPO Antibodies)/MPL (show MPL Antibodies) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 (show MECOM Antibodies) leukemia.

  3. Direct binding of kindlin-3 (show FERMT3 Antibodies) to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.

  4. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  5. reduction of talin-beta3 integrin (show ITGB3 Antibodies) binding affinity results in decelerated alphaIIbbeta3 integrin activation and protection from arterial thrombosis without pathological bleeding

  6. deficiency of Dok-2 leads to dysregulated integrin alphaIIbbeta3-dependent cytosolic calcium flux and phosphatidylinositol(3,4)P2 accumulation.

  7. Platelets lacking ERp57 (show PDIA3 Antibodies) have defective activation of the alphaIIbbeta3 integrin and platelet aggregation. The defect in aggregation was corrected by the addition of exogenous ERp57 (show PDIA3 Antibodies), implicating surface ERp57 (show PDIA3 Antibodies) in platelet aggregation.

  8. Data indicate that Pyk2 (show PTK2B Antibodies) is a common signaling effector downstream of both G12 (show TCF3 Antibodies)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.

  9. These results identify a novel pathway of integrin alphaIIbbeta3 outside-in signaling and recognize the tyrosine kinase Pyk2 as a major regulator of platelet adhesion and spreading on fibrinogen.

  10. identified Hic-5 (show TGFB1I1 Antibodies) as a novel and specific regulatory factor for thrombin (show F2 Antibodies)-induced alphaIIbbeta3 activation and subsequent platelet aggregation in mice.

Integrin alpha 2b (ITGA2B) Antigen Profile

Protein Summary

ITGA2B encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Gene names and symbols associated with ITGA2B

  • integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) (ITGA2B) antibody
  • integrin alpha 2b (Itga2b) antibody
  • AI172977 antibody
  • alphaIIb antibody
  • BDPLT2 antibody
  • BDPLT16 antibody
  • CD41 antibody
  • CD41B antibody
  • GP2B antibody
  • GpIIb antibody
  • GT antibody
  • GTA antibody
  • HPA3 antibody

Protein level used designations for ITGA2B

GPalpha IIb , integrin alpha-IIb , platelet fibrinogen receptor, alpha subunit , platelet membrane glycoprotein IIb , platelet-specific antigen BAK , glycoprotein GPIIb , integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) , integrin alpha 2b , GP IIb , alpha IIb , platelet glycoprotein IIb of IIb/II Ia complex

3674 Homo sapiens
403789 Canis lupus familiaris
454730 Pan troglodytes
515011 Bos taurus
16399 Mus musculus
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