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The product of ITGAX belongs to the integrin alpha chain family.
It seems unlikely that variants at the ITGAX (show ITGA3 Antibodies) gene are responsible for the recurrent airway obstruction QTL in European Warmblood horses.
The cloning and sequence determination of the horse alpha subunit (show POLG Antibodies) of the integrin CD11c (show ITGA3 Antibodies)/CD18 (show ITGB2 Antibodies), a marker of dendritic cells.
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
integrin alpha X
, integrin alpha-X