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ITGAL encodes the integrin alpha L chain. Additionally we are shipping ITGAL Kits (20) and ITGAL Proteins (13) and many more products for this protein.
Showing 10 out of 814 products:
Mouse (Murine) Monoclonal ITGAL Primary Antibody for FACS - ABIN118135
Falanga, Butcher: Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model. in European journal of immunology 1991
Show all 7 references for ABIN118135
Rat (Rattus) Monoclonal ITGAL Primary Antibody for FACS, IHC (fro) - ABIN120404
Tamatani, Kotani, Miyasaka: Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies. in European journal of immunology 1991
Show all 4 references for ABIN120404
Human Monoclonal ITGAL Primary Antibody for IF, IP - ABIN968200
Larson, Corbi, Berman, Springer: Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily. in The Journal of cell biology 1989
Show all 4 references for ABIN968200
Human Monoclonal ITGAL Primary Antibody for FACS - ABIN1105774
Galon, Gauchat, Mazières, Spagnoli, Storkus, Lötze, Bonnefoy, Fridman, Sautès: Soluble Fcgamma receptor type III (FcgammaRIII, CD16) triggers cell activation through interaction with complement receptors. in Journal of immunology (Baltimore, Md. : 1950) 1996
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Human Monoclonal ITGAL Primary Antibody for FACS - ABIN1105768
Vermot-Desroches, Wijdenes, Valmu, Roy, Pigott, Nortamo, Gahmberg: A CD44 monoclonal antibody differentially regulates CD11a/CD18 binding to intercellular adhesion molecules CD54, CD102 and CD50. in European journal of immunology 1995
Show all 3 references for ABIN1105768
Mouse (Murine) Monoclonal ITGAL Primary Antibody for Func, FACS - ABIN118136
Trowbridge, Omary: Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1. in The Journal of experimental medicine 1982
Show all 2 references for ABIN118136
Human Monoclonal ITGAL Primary Antibody for FACS - ABIN1105775
Canfield, Khakoo: The nonintegrin laminin binding protein (p67 LBP) is expressed on a subset of activated human T lymphocytes and, together with the integrin very late activation antigen-6, mediates avid cellular adherence to laminin. in Journal of immunology (Baltimore, Md. : 1950) 1999
Show all 2 references for ABIN1105775
Rat (Rattus) Monoclonal ITGAL Primary Antibody for Func, FACS - ABIN120407
Tamatani, Kotani, Tanaka, Miyasaka: Molecular mechanisms underlying lymphocyte recirculation. II. Differential regulation of LFA-1 in the interaction between lymphocytes and high endothelial cells. in European journal of immunology 1991
Show all 2 references for ABIN120407
Human Monoclonal ITGAL Primary Antibody for FACS, IF - ABIN1105773
Wright, Jong: Adhesion-promoting receptors on human macrophages recognize Escherichia coli by binding to lipopolysaccharide. in The Journal of experimental medicine 1987
Mouse (Murine) Monoclonal ITGAL Primary Antibody for FACS - ABIN114187
Hogarth, Walker, McKenzie, Springer: The Ly-15 alloantigenic system: a genetically determined polymorphism of the murine lymphocyte function-associated antigen-1 molecule. in Proceedings of the National Academy of Sciences of the United States of America 1985
Data show that the marker antigen CD11A- fraction of hematopoietic stem cells (HSCs) contains all functional HSC (show FUT1 Antibodies) activity, with the CD11A+ fraction composed of more differentiated cells that lack long-term self-renewal activity.
competitive bone marrow-reconstitution assays revealed an essential role for CD11a in the generation of thymocytes and mature T and B cells
Through the use of interval-specific SNP haplotype analysis, we further refined the Civq1 locus and identified integrin alpha L (Itgal) as one of the causative genes for Civq1
CD11a plays a crucial role in adipose tissue inflammation by participating in T-cell infiltration and activation.
CD11a and CD11b (show ITGAM Antibodies) mediate leukocyte adhesion in both arterioles and venules as well as trapping in capillaries in the lung.
LFA-1/ICAM-1 (show ICAM1 Antibodies)-dependent interactions between T cells and dendritic cells play a crucial role not only in supporting firm arrest during Ag recognition but also in facilitating the Ag scanning processes.
Data indicate that the dimerization of integrin alphaL and beta2 is highly dependent on gp96 (show HSP90B1 Antibodies).
LFA-1-mediated firm adhesion under conditions of shear flow requires downstream integrin signaling, which is dependent on calcium/calmodulin and the actin cytoskeleton.
Taken together, these findings demonstrated that CD11a expression contributes to expansion and differentiation of primary CD8 (show CD8A Antibodies) T cells but may be dispensable for secondary responses to Listeria monocytogenes infection.
However, this process was pertussis toxin sensitive and dependent on the integrin LFA-1.
Suggest possible role for lymphocyte CD11a in the pathogenesis immune thrombocytopenia.
Data show that interleukin-18 (show IL18 Antibodies) was involved in the eosinophil-mediated death of colon carcinoma cells via upregulation of CD11a/CD18 (show ITGB2 Antibodies) and ICAM-1 (show ICAM1 Antibodies) adhesion molecules.
shear-induced CD11 (show CD1D Antibodies)/CD18 (show ITGB2 Antibodies) cleavage is phenotypic of neutrophilic cells, including those derived from HL60 cells
Data show that leucocyte function-associated antigen-1 (integrin alphaLbeta2), DNAX accessory molecule-1 (DNAM-1 (show CD226 Antibodies)) or tumour necrosis factor (show TNF Antibodies)-related apoptosis-inducing ligand (TRAIL) enhance osteoclast survival when co-cultured with activated NK cells.
LFA-1 function is regulated through conformational changes that include the modulation of ligand binding affinity and molecular extension.
the blocking of LFA-1/ICAM-1 (show ICAM1 Antibodies) interaction resulted in a significant increase in the percentage of IL-17 (show IL17A Antibodies)(+) T cells expanded in nonclassical monocyte/T-cell cocultures
Studied signaling mechanisms of Lymphocyte function-associated antigen-1 (LFA-1) using NMR analysis of the dynamics of the LFA-1 I-domain.
CD11a, CD11c (show ITGAX Antibodies), and CD18 (show ITGB2 Antibodies) gene polymorphisms and susceptibility to Behcet's disease in Koreans.
PIK3R3, ITGB1, ITGAL, and ITGA6, were involved in the regulation of actin cytoskeleton that link to triple-negative breast cancer migration.
ITGAL is overexpressed in systemic lupus erythematosus CD4 (show CD4 Antibodies)+ T cells, but expression is not linked to the typical clinical and serological parameters associated with the disease.
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
CD11 antigen-like family member A
, alpha L integrin
, integrin alpha-L
, leukocyte adhesion glycoprotein LFA-1 alpha chain
, leukocyte function-associated molecule 1 alpha chain
, lymphocyte antigen 15
, lymphocyte function associated antigen 1, alpha polypeptide
, LFA-1 alpha
, antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide
, integrin gene promoter
, lymphocyte function-associated antigen 1
, integrin LFA1
, lymphocyte function-associated antigen 1, alpha polypeptide
, antigen CD11A
, lymphocyte function-associated antigen 1, alpha