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Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Additionally we are shipping Integrin beta 4 Kits (24) and Integrin beta 4 Proteins (9) and many more products for this protein.
Showing 10 out of 368 products:
Human Monoclonal Integrin beta 4 Primary Antibody for IF, WB - ABIN968433
Mainiero, Pepe, Wary, Spinardi, Mohammadi, Schlessinger, Giancotti: Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. in The EMBO journal 1995
Show all 2 references for ABIN968433
Mouse (Murine) Monoclonal Integrin beta 4 Primary Antibody for FACS - ABIN120280
Kennel, Foote, Falcioni, Sonnenberg, Stringer, Crouse, Hemler: Analysis of the tumor-associated antigen TSP-180. Identity with alpha 6-beta 4 in the integrin superfamily. in The Journal of biological chemistry 1989
Show all 2 references for ABIN120280
Mouse (Murine) Monoclonal Integrin beta 4 Primary Antibody for FACS, IHC (fro) - ABIN120281
Kennel, Godfrey, Chang, Lankford, Foote, Makkinje: The beta 4 subunit of the integrin family is displayed on a restricted subset of endothelium in mice. in Journal of cell science 1992
Show all 2 references for ABIN120281
Mouse (Murine) Monoclonal Integrin beta 4 Primary Antibody for FACS, IHC (fro) - ABIN260163
Lämmermann, Bader, Monkley, Worbs, Wedlich-Söldner, Hirsch, Keller, Förster, Critchley, Fässler, Sixt: Rapid leukocyte migration by integrin-independent flowing and squeezing. in Nature 2008
Human Monoclonal Integrin beta 4 Primary Antibody for FACS - ABIN319861
Kennel, Epler, Lankford, Foote, Dickas, Canamucio, Cavalierie, Cosimelli, Venturo, Falcioni: Second generation monoclonal antibodies to the human integrin alpha 6 beta 4. in Hybridoma 1990
Human Monoclonal Integrin beta 4 Primary Antibody for FACS, IHC - ABIN1724805
Liu, Qin, Liu, Xiang: Downregulation of integrin β4 decreases the ability of airway epithelial cells to present antigens. in PLoS ONE 2012
Human Monoclonal Integrin beta 4 Primary Antibody for FACS, ICC - ABIN4900094
Mierke, Frey, Fellner, Herrmann, Fabry: Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces. in Journal of cell science 2011
Ferret Monoclonal Integrin beta 4 Primary Antibody for ICC, FACS - ABIN260162
Tra, van Neck, Hovius, van Osch, Perez-Amodio: Characterization of a three-dimensional mucosal equivalent: similarities and differences with native oral mucosa. in Cells, tissues, organs 2012
Expression of the beta 4 subunit of the alpha 6 beta 4 integrin induces monocytic differentiation of 32D/v-Abl (show ABL1 Antibodies) transformed cells. alpha 6 beta 4 integrin promotes growth arrest and differentiation by modulating Abl (show ABL1 Antibodies) kinases and p73 (show ARHGAP24 Antibodies) protein pathway(s).
Integrin beta4 contributes to mammary gland development by sustaining PTHrP (show PTHLH Antibodies) expression and enabling PTHrP (show PTHLH Antibodies) signaling.
keratins have a role in controlling beta4-integrin endocytosis involving a plectin (show PLEC Antibodies)-Erk1/2 (show MAPK1/3 Antibodies)-dependent mechanism relevant for epidermal differentiation and pathogenesis
Up-regulation of integrin beta4 and TRPV1 (show TRPV1 Antibodies) in migrating keratinocytes.
Ectopic induction of Nur77 (show NR4A1 Antibodies) in endothelial cells is sufficient to improve skin wound healing. Furthermore, TR3/Nur77 (show NR4A1 Antibodies) regulates the expression of integrin beta4 by targeting its promoter activity.
Col17a1 (show COL17A1 Antibodies)/ keratinocytes exhibited increased spreading on laminin 332 and accelerated, but less directed cell motility. These effects were accompanied by increased expression of the integrin subunits beta4 and beta1.
Both annexin A7 (show ANXA7 Antibodies) and integrin beta4 were essential for small molecule, 6-amino-2, 3-dihydro-3-hydroxymethyl-1, 4-benzoxazine-induced autophagy.
Findings indicate a function for Id2 in regulating Snai1 (show SNAI1 Antibodies)-mediated repression of integrin beta4.
Targeted deletion of the signaling domain of beta4 inhibited prostate tumor growth and progression in response to loss of p53 (show TP53 Antibodies) and Rb function in a model of prostate cancer (PB-TAg mice).
Deficiency of integrin alpha(6 (show ITGA6 Antibodies))beta(4) is modestly but significantly suppressed reporter-gene transduction by papillomaviruses in conditional integrin beta(4) knockout mice.
For the in vivo experiment, miR (show MLXIP Antibodies)-182-5p overexpression also promoted the growth and progression of prostate cancer tumors. In this regard, we suggest that miR (show MLXIP Antibodies)-182-5p may be a key androgen receptor (show AR Antibodies)-regulated factor that contributes to the development and metastasis of Chinese prostate cancers and may be a potential target for the early diagnosis and therapeutic studies of prostate cancer.
data indicate that the beta4 integrin/FAK (show PTK2 Antibodies) complex and subsequent FAK (show PTK2 Antibodies) activation are essential regulators during the tumorigenicity of colon cancer
This work investigates alpha6beta4 integrin genetic variations (A380T and R1281W) and breast cancer risk in an Argentinian population. No subjects carrying the R1281W mutation in the ITGB4 gene were found and this absence could reflect its high deleterious impact on proteins, so it would be eliminated from the population by natural selection.
analysis of deletions in ITGB4 gene causing epidermolysis bullosa with pyloric atresia [case series]
ITGB4 is overexpressed in hepatocellular carcinoma tissues and promotes metastases of HCC (show FAM126A Antibodies) by conferring anchorage independence through EGFR (show EGFR Antibodies)-dependent FAK (show PTK2 Antibodies)-AKT (show AKT1 Antibodies) activation.
High vimentin and low beta4 integrin protein levels are associated with poor survival in oral squamous carcinoma patients.
Endothelial cell overexpression of mutant ITGB4 with specific tyrosines mutated to phenylalanine (Y1440, Y1526 Y1640, or Y1422) resulted in significantly attenuated CS-induced cytokine expression.
This study describes a pro-metastatic EGFR (show EGFR Antibodies)/Src (show SRC Antibodies)-dependent beta4 integrin/FAK (show PTK2 Antibodies) complex that is involved in breast cancer malignancy and is a novel therapeutic target for triple-negative breast cancer.
These data suggest that the p53 (show TP53 Antibodies)(R248) mutant endows ovarian cancer cells with increased adhesiveness and that integrin beta4 and Akt (show AKT1 Antibodies) signalling are associated with the mutation-enhanced ovarian cancer-mesothelial cell adhesion.
Changes in beta-integrins gene expression in human prostate cancer cells following ITGB4 knockdown.
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
integrin beta 4
, integrin beta-4
, CD104 antigen
, integrin beta-4 subunit