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mediates adhesion to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) [RGD, Feb 2006].. Additionally we are shipping Integrin beta 7 Antibodies (154) and Integrin beta 7 Kits (2) and many more products for this protein.
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beta7 integrin, when expressed by hematopoietic stem cells (HSC (show FUT1 Proteins)), interacted with its endothelial ligand MAdCAM-1 (show MADCAM1 Proteins) in the Bone marrow microenvironment, thereby promoting HSC (show FUT1 Proteins) homing and engraftment.
CCR9 (show CCR9 Proteins) and Integrin-beta7 expression has a differential effect on graft fate during acute graft-versus-host disease (GVHD) of the liver depending on the GVHD target tissue.
The E-cadherin (show CDH1 Proteins) beta-7 integrin pathway probably controls migration of enterocytes within the small intestinal surface lining epithelial layer.
KLF3 (show KLF3 Proteins) acts as transcriptional repressor for the leukocyte-specific integrin beta7 (Itgb7, Ly69) by binding to the beta7 promoter, as revealed by chromatin immunoprecipitation.
Mice lacking beta7 integrins in the innate immune compartment are more susceptible to intestinal inflammation, which is correlated with a requirement of beta7 integrins to reconstitute gut (show GUSB Proteins) mononuclear phagocytes with tolerogenic potential.
E-cadherin (show CDH1 Proteins) and alpha(E)beta(7) integrin on dendritic epidermal T cells regulate their activation threshold through binding to E-cadherin (show CDH1 Proteins) on keratinocytes
lack of alpha4beta7 or E-selectin (show SELE Proteins) significantly reduced trafficking of CD4 (show CD4 Proteins) T cells to the GT of mice infected with C. muridarum.
results suggest the importance of alphaEbeta7 expression by TGF-beta (show TGFB1 Proteins) in selective localization of intestinal intraepithelial T lymphocytes
The induction of alpha4beta7 following activation of mouse cells with the APC (show APC Proteins)-dependent stimulus soluble anti-CD3 (show CD3E Proteins) has been examined. (alpha4beta7 integrin)
Studies with knockout mice show beta7 Integrin expression is not required for the localization of T cells to the intestine and colitis pathogenesis. IL-2 (show IL2 Proteins) knockout mice crossed with beta7 knockouts did not get colitis.
Collectively, these data suggest a role for alpha4beta7 integrin in HIV infection that is influenced by both viral and host factors including the sequence of the HIV gp120 (show ITIH4 Proteins) alpha4beta7 binding motif, the cytokine milieu and bacterial vaginosis in the genital tract.
circulating trisomy 12 CLL cells also have increased expression of the integrins CD11b (show ITGAM Proteins), CD18 (show ITGB2 Proteins), CD29 (show ITGB1 Proteins), and ITGB7, and the adhesion molecule (show NCAM1 Proteins) CD323.
Disruption of the hydrophobic contacts induces the active conformation of integrin alpha 4 (show ITGA4 Proteins) beta 7.
Only rotavirus specific CD4 (show CD4 Proteins) T cells expressed intestinal homing receptors alpha4beta7 and CCR9 (show CCR9 Proteins).
Data indicate that signaling by HIV-1 gp120 (show ITIH4 Proteins) through integrin alpha4beta7 resulted in increased expression of the immunosuppressive cytokine TGF-beta1 (show TGFB1 Proteins) and FcRL4 (show FCRL4 Proteins).
Integrin alpha4beta7 binds gp120 (show ITIH4 Proteins) but does not mediate HIV envelope-induced death signaling.
Consistent with structural predictions, strain increases beta-integrin binding to FLNA (show FLNA Proteins), whereas it causes FilGAP (show ARHGAP24 Proteins) to dissociate from FLNA (show FLNA Proteins), providing a direct and specific molecular basis for cellular mechanotransduction
Data show that integrin beta7 and CCR6 (show CCR6 Proteins) identify four distinct stages of memory CD4 (show CD4 Proteins)+ T cell differentiation.
findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 (show MADCAM1 Proteins) expressed on HEVs in GALT (show GALT Proteins) and could potentially serve as an anti-inflammatory drug inhibiting GALT (show GALT Proteins)-specific lymphocyte migration
mediates adhesion to mucosal addressin cell adhesion molecule-1 (MAdCAM-1)
M290 IEL antigen
, integrin beta-7
, integrin beta-P
, gut homing receptor beta subunit
, integrin beta 7 subunit