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Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Additionally we are shipping Integrin-Linked Kinase Kits (27) and Integrin-Linked Kinase Proteins (25) and many more products for this protein.
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Human Polyclonal ILK Primary Antibody for IHC (p), WB - ABIN391993
Troussard, Mawji, Ong, Mui, St -Arnaud, Dedhar: Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation. in The Journal of biological chemistry 2003
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Human Polyclonal ILK Primary Antibody for EIA - ABIN358419
Li, Yang, Dai, Wu, Liu: Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. in The Journal of clinical investigation 2003
Show all 5 references for ABIN358419
Human Polyclonal ILK Primary Antibody for EIA, IHC (p) - ABIN359885
Marotta, Parhar, Owen, Dedhar, Salh: Characterisation of integrin-linked kinase signalling in sporadic human colon cancer. in British journal of cancer 2003
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Human Polyclonal ILK Primary Antibody for EIA, IHC (p) - ABIN359883
Cordes, van Beuningen: Cell adhesion to the extracellular matrix protein fibronectin modulates radiation-dependent G2 phase arrest involving integrin-linked kinase (ILK) and glycogen synthase kinase-3beta (GSK-3beta) in vitro. in British journal of cancer 2003
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Human Polyclonal ILK Primary Antibody for IHC (p), WB - ABIN391997
Fukuda, Guo, Shi, Wu: CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt. in The Journal of cell biology 2003
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Human Polyclonal ILK Primary Antibody for IHC, ELISA - ABIN1532048
Hannigan, Leung-Hagesteijn, Fitz-Gibbon, Coppolino, Radeva, Filmus, Bell, Dedhar: Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. in Nature 1996
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Human Polyclonal ILK Primary Antibody for IHC, WB - ABIN223143
Hu, Sun, Xie, Huang, Jia, Yao, Ge: Rosuvastatin changes cytokine expressions in ischemic territory and preserves heart function after acute myocardial infarction in rats. in Journal of cardiovascular pharmacology and therapeutics 2013
Human Polyclonal ILK Primary Antibody for DB - ABIN650820
Srikanth, Das, Berns, Kim, Stupp, Kessler: Nanofiber-mediated inhibition of focal adhesion kinase sensitizes glioma stemlike cells to epidermal growth factor receptor inhibition. in Neuro-oncology 2013
Targeted knockdown of the integrin focal adhesion complex components beta-integrin, PINCH (show LIMS1 Antibodies), and integrin-linked kinase caused formation of multinucleate epidermal cells within the Drosophila larval epidermis.
PINCH (show LIMS1 Antibodies) and ILK have an independent capacity to localize at muscle attachment sites in vivo.
ILK functions as an essential hub in the assembly of its partner proteins at sites of integrin adhesion.
Work provides a new tool for studying mouse oligodendrocyte precursor cell migration and highlights the role of integrin-linked kinase in its regulation on extracellular matrix proteins relevant to multiple sclerosis.
We conclude that ILK negatively and independently of PI3K regulated MEF2C (show MEF2C Antibodies) phosphorylation activity and MCK (show CKM Antibodies) mRNA expression in C2C12 cells
high extracellular concentration of phosphate induced senescence in cultured smooth muscle through the activation of IGF-1 (show IGF1 Antibodies) receptor and ILK overexpression
This study demonstrates a role for ILK in regulating laminin2-mediated adhesion and Ln-2-independent growth cone size/activity in oligodendrocyte
ILK is indispensable for Brain-derived neurotrophic factor-mediated hippocampal neurogenesis and memory enhancement upon Environment enrichment stimuli via regulating glycogen synthase kinase-3beta activity.
ELMO2 (show ELMO2 Antibodies)-RhoG-ILK complex has a key role in integrin-independent stabilization of the microtubule network in differentiated keratinocytes.
ILK is a key regulator of the bulge extracellular matrix microenvironment, thereby governing the activation and maintenance of hair follicle stem cells.
CTGF (show CTGF Antibodies) overexpression induces epithelial to mesenchymal transition in mouse primary AT II cells, which is mediated by ILK
These data demonstrate that ILK is a linker between Integrin receptors and the Dynactin (show DCTN1 Antibodies) complex to regulate mitotic spindle orientation.
These observations demonstrate an important role for beta1-integrin/ILK signaling in regulating astrogliosis from ESCs (show NR2E3 Antibodies) and suggest ILK as a potential target for limiting glial scar formation after nervous system injury.
Heart failure in recessive embryonic lethal zebrafish mutant main squeeze (msq) mutants is due to a mutation in the integrin-linked kinase (ilk) gene.
The lost-contact mutant on chromosome 10 encodes a nonsense mutation (Y319X) associated with defective cardiomyocytes & endothelial cells that leads to severe myocardial dysfunction. There is epistatic regulation between laminin-alpha4, integrin, & Ilk.
Data show that integrin-linked kinase is an essential component downstream of laminin and integrin alpha7, providing strengthening of skeletal muscle fibre adhesion with the extracellular matrix.
Twist-ITGB1 (show ITGB1 Antibodies)-FAK (show PTK2 Antibodies)/ILK pathway and their downstream signaling network dictate the Twist-induced EMT (show ITK Antibodies) process in human mammary epithelial cells and breast cancer cells
Results indicated that ILK is imperative in the development and progression of oral squamous cell carcinoma.
Periostin (show POSTN Antibodies) enhanced ensometrial stromal cell migration, invasion, and adhesion due to the ILK1/Akt (show AKT1 Antibodies) signal pathway.
our data suggest an essential role of PINCH1 (show LIMS1 Antibodies), ILK and ILKAP (show ILKAP Antibodies) for the radioresistance of p53 (show TP53 Antibodies)-wildtype glioblastoma multiforme cells
ILK inhibition and knockdown effects senescence in an Rb-dependent manner.
ILK may have an important role in the progression of NSCLC, possibly through up-regulation of Snail (show SNAI1 Antibodies) and MRP1 (show MDM4 Antibodies).
integrin linked kinase may play a role in cell proliferation, and cell migration in aggressive thyroid cancers.
knockdown of ILK inhibits glioma cell migration, invasion and proliferation through upregulation of E-cadherin (show CDH1 Antibodies) and downregulation of cyclin D1 (show CCND1 Antibodies). Our results suggest that ILK may serve as a promising therapeutic target for glioma.
Overexpression of CD29 (show ITGB1 Antibodies) decreased E-cadherin (show CDH1 Antibodies), but increased fibronectin (show FN1 Antibodies), vimentin (show VIM Antibodies), ILK activity.
Integrin-linked kinase (ILK, MGC129022) is an important regulator of the endothelial phenotype and vascular network formation by directing the assembly and/or maturation of alpha5beta1-competent matrix-forming adhesions.
Rac1 only partially restores the spreading defects of integrin linked kinasse (ILK)-depleted cells, suggesting that an additional ILK-dependent signal is required for cell spreading.
Profilin (show PFN1 Antibodies)-dependent dissociation of G-actin (show ACTB Antibodies)-Tbeta4 complexes simultaneously liberates actin for filament assembly and facilitates Tbeta4 binding to integrin-linked kinase (ILK) in the lamellipodia.
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. This gene encodes a serine/threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
, Integrin-linked kinase
, integrin linked kinase
, integrin-linked protein kinase
, integrin-linked kinase
, Integrin-linked protein kinase
, integrin binding protein kinase
, main squeeze
, beta-integrin-linked kinase
, 59 kDa serine/threonine-protein kinase
, integrin-linked kinase-2