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ICAM4 encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. Additionally we are shipping ICAM4 Kits (15) and ICAM4 Proteins (12) and many more products for this protein.
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Human Polyclonal ICAM4 Primary Antibody for WB - ABIN516775
Zhu, Zennadi, Xu, Eu, Torok, Telen, McMahon: Impaired adenosine-5'-triphosphate release from red blood cells promotes their adhesion to endothelial cells: a mechanism of hypoxemia after transfusion. in Critical care medicine 2011
Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM (show BCAM Antibodies), ICAM-4 and LFA-3, both in percentage of positive cells and in surface density.
ICAM-1 (show ICAM1 Antibodies) and ICAM-4 play roles in host cell invasion by M. tuberculosis and P. falciparum, respectively.
Seven variant ICAM4 alleles were found, distinct from the wild-type ICAM4 allele (GenBank KF712272), known as LW*05 and encoding LW(a) .
Data from differentiating cultured erythroid precursor cells suggest that RhAG (Rh-associated glycoprotein (show RHAG Antibodies)) knockdown abolishes Rh blood group (show DARC Antibodies) expression (ICAM4; RhoD [ras homolog family member D]; CD47 Rh-related antigen (show CD47 Antibodies)) in erythroid cells.
Erythrocyte plasma membrane-bound ERK1/2 (show MAPK1/3 Antibodies) activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium.
In a transgenic mouse model of sickle cell disease ICAM-4 is implicated in abnormal adhesiveness of erythrocytes to endothelium.
ICAM-4 as the first red blood cells protein ligand of platelets that may have relevant physiological significance
binds to the I domains of the CD11a (show ITGAL Antibodies)/CD18 (show ITGB2 Antibodies) and CD11b/CD18 (show ITGAM Antibodies) leukocyte integrins
12 single amino-acid changes in ICAM4 affected the interaction of ICAM-4 with alpha(V) integrins
Different integrins bind to different but partly overlapping sites on ICAM4, and ICAM4 may accommodate multiple integrin receptors present on leukocytes, platelets and endothelial cells.
A novel second splice cDNA encodes an ICAM-4 isoform lacking the membrane-spanning domain. Erythroblasts express both isoforms. This new isoform, ICAM (show ICAM1 Antibodies)-4S, may modulate membrane-associated ICAM-4 binding & regulate erythroblast molecular attachments.
ICAM-4 is critical in erythroblastic island formation via ICAM-4/alpha(V) adhesion
This gene encodes the Landsteiner-Wiener (LW) blood group antigen(s) that belongs to the immunoglobulin (Ig) superfamily, and that shares similarity with the intercellular adhesion molecule (ICAM) protein family. This ICAM protein contains 2 Ig-like C2-type domains and binds to the leukocyte adhesion LFA-1 protein. The molecular basis of the LW(A)/LW(B) blood group antigens is a single aa variation at position 100\; Gln-100=LW(A) and Arg-100=LW(B). Alternative splicing results in multiple transcript variants encoding distinct isoforms.
, LW blood group protein
, Landsteiner-Wiener blood group antigen a
, Landsteiner-Wiener blood group glycoprotein
, intercellular adhesion molecule 4
, intercellular adhesion molecule 4 (LW blood group)
, Landsteiner-Wiener blood group protein
, intercellular adhesion molecule 4, Landsteiner-Wiener blood group
, LW glycoprotein