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IRF6 encodes a member of the interferon regulatory transcription factor (IRF) family. Additionally we are shipping IRF6 Proteins (9) and many more products for this protein.
Showing 10 out of 94 products:
Human Polyclonal IRF6 Primary Antibody for ELISA, IHC - ABIN4327608
Hu, Liu, Li, Ozturk, Gurumurthy, Romano, Sinha, Nawshad: TGFβ3 regulates periderm removal through ΔNp63 in the developing palate. in Journal of cellular physiology 2015
Show all 4 references for ABIN4327608
Cow (Bovine) Polyclonal IRF6 Primary Antibody for IHC, WB - ABIN2779406
Iwata, Suzuki, Pelikan, Ho, Sanchez-Lara, Urata, Dixon, Chai: Smad4-Irf6 genetic interaction and TGFβ-mediated IRF6 signaling cascade are crucial for palatal fusion in mice. in Development (Cambridge, England) 2013
Human Polyclonal IRF6 Primary Antibody for IHC, ELISA - ABIN184730
Kondo, Schutte, Richardson, Bjork, Knight, Watanabe, Howard, de Lima, Daack-Hirsch, Sander, McDonald-McGinn, Zackai, Lammer, Aylsworth, Ardinger, Lidral, Pober, Moreno, Arcos-Burgos, Valencia et al.: Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. ... in Nature genetics 2002
Cow (Bovine) Polyclonal IRF6 Primary Antibody for WB - ABIN2781490
Beausoleil, Jedrychowski, Schwartz, Elias, Villén, Li, Cohn, Cantley, Gygi: Large-scale characterization of HeLa cell nuclear phosphoproteins. in Proceedings of the National Academy of Sciences of the United States of America 2004
Here, the authors have established that IRF6 promotes the differentiation of oral keratinocytes in response to Porphyromonas gingivalis.
It has been shown that pathogenic IRF6 mutations are likely to occur in a small fraction (~0.3%) of individuals with apparent nonsyndromic orofacial cleft, across multiple ethnic groups.
The 8q24 region plays a role in cleft lip/palate and the IRF6 G/A haplotype (rs2235371/rs642961) increases the risk for oral cleft in the Brazilian population.
Studied the correlation of IRF6 rs642961 polymorphism and NSCL (show NHLH1 Antibodies)/P in Iranian NSCL (show NHLH1 Antibodies)/P families; the family-based association analysis revealed no significant association between IRF6 rs642961 genotypes and an increased NSCL (show NHLH1 Antibodies)/P risk.
Mutations in IRF6 cause Van der Woude and popliteal pterygium syndrome and contribute to nonsyndromic cleft lip phenotypes but have not previously been associated with a PRS phenotype.
IRF6 is likely to promote inflammation to P. gingivalis through its regulation of IL-36gamma.
results confirmed the involvement of the IRF6 variants rs642961 and rs2235371 in the etiology of nonsyndromic cleft lip with or without cleft palate in a Chinese population.
The IRF6 AP-2a binding site promoter polymorphism is associated with isolated oral clefts in Latvia.
genetic polymorphism of the IRF6 gene is associated with increased risk of nsCLP in a Xinjiang Uyghur population.
Data suggest that the toll like receptor 3 (TLR3 (show TLR3 Antibodies))-interferon regulatory factor 6 protein (IRF6)-interleukin-23 subunit p19 (p19 (show IL23A Antibodies))/EBI3 (show EBI3 Antibodies) protein axis may regulate keratinocyte functions in the skin.
Fish IRF6 is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (show MYD88 Antibodies) and TBK1 (show TBK1 Antibodies), suggesting that differences in the IRF6 regulation pattern exist between lower and higher vertebrates.
Authors report that Kruppel-like factor 17 (Klf17 (show KLF17 Antibodies)), like Grhl3 (show GRHL3 Antibodies), acts downstream of Irf6 in this network in zebrafish periderm.
In zebrafish periderm, grainyhead-like 3 (grhl3 (show GRHL3 Antibodies)) (an ancient regulator of the epidermal permeability barrier), was identified as acting downstream of Irf6. Simultaneous inhibition of grhl1 (show GRHL1 Antibodies) and grhl3 (show GRHL3 Antibodies) disrupted periderm differentiation in zebrafish.
analysis of zebrafish expression of IRF6
These experiments reveal a conserved role for maternally-encoded Irf6 in differentiation of a simple epithelium in X. laevis and D. rerio.
These data provide the first mechanistic insight into the heightened caries susceptibility associated with CLP (show HAPLN1 Antibodies) and indicate a direct role for the major CLP (show HAPLN1 Antibodies) gene Irf6 in salivary gland development and a significant role in regulating oral immunity in mice.
that downregulation of interferon regulatory factor 6 affords protection against TNI (show TNNI2 Antibodies) through Akt (show AKT1 Antibodies)-eNOS (show NOS3 Antibodies) pathway-mediated antioxidative and anti-inflammatory activity
Irf6 is required for resistance to Lipopolysaccharides-induced endotoxic shock. In addition, Irf6-deficient bone marrow-derived neutrophils exhibited increased chemotactic index and velocity compared with wild-type cells in vitro.
TGFbeta3 increases IRF6 expression and subsequently regulates SNAI2 (show SNAI2 Antibodies) expression; IRF6 appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2 (show SNAI2 Antibodies).
Pvrl1 (show PVRL1 Antibodies) is a bona fide target gene of the transcription factor p63 (show CKAP4 Antibodies), whereas Pvrl4 (show PVRL4 Antibodies) regulation is linked to epidermal differentiation and is under Irf6
Data suggest that Irf6 functions through the RhoA (show RHOA Antibodies) pathway to regulate cellular migration.
These results support a role for IRF6 in brain morphometry and provide evidence for a potential genetic link to abnormal brain development in orofacial clefting.
Irf6 plays important cell-autonomous and non-cell-autonomous roles in muscular differentiation and cytoskeletal formation in the tongue.
Irf6 plays a critical role in regulating epithelial invagination
IRF6 and SMAD4 (show SMAD4 Antibodies) synergistically regulate the fate of the medial edge epithelium (MEE), and TGFbeta (show TGFB1 Antibodies)-mediated Irf6 activity is responsible for MEE degeneration during palatal fusion in mice.
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.
interferon regulatory factor 6
, interferon regulatory factor 6-like