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Interferon Regulatory Factor 6 (IRF6) ELISA Kits

IRF6 encodes a member of the interferon regulatory transcription factor (IRF) family. Additionally we are shipping IRF6 Antibodies (94) and IRF6 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human IRF6 IRF6 3664 O14896
Anti-Mouse IRF6 IRF6 54139 P97431
Anti-Rat IRF6 IRF6 364081  
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More ELISA Kits for IRF6 Interaction Partners

Human Interferon Regulatory Factor 6 (IRF6) interaction partners

  1. IRF6 dysregulation may be involved in the development of Vulvar Squamous Cell Carcinoma from vulvar lichen sclerosus (VLS). Methylation of the IRF6 promoter may be a marker of cancer risk in patients with VLS.

  2. Here, the authors have established that IRF6 promotes the differentiation of oral keratinocytes in response to Porphyromonas gingivalis.

  3. It has been shown that pathogenic IRF6 mutations are likely to occur in a small fraction (~0.3%) of individuals with apparent nonsyndromic orofacial cleft, across multiple ethnic groups.

  4. The 8q24 region plays a role in cleft lip/palate and the IRF6 G/A haplotype (rs2235371/rs642961) increases the risk for oral cleft in the Brazilian population.

  5. Studied the correlation of IRF6 rs642961 polymorphism and NSCL (show NHLH1 ELISA Kits)/P in Iranian NSCL (show NHLH1 ELISA Kits)/P families; the family-based association analysis revealed no significant association between IRF6 rs642961 genotypes and an increased NSCL (show NHLH1 ELISA Kits)/P risk.

  6. Mutations in IRF6 cause Van der Woude and popliteal pterygium syndrome and contribute to nonsyndromic cleft lip phenotypes but have not previously been associated with a PRS phenotype.

  7. IRF6 is likely to promote inflammation to P. gingivalis through its regulation of IL-36gamma.

  8. results confirmed the involvement of the IRF6 variants rs642961 and rs2235371 in the etiology of nonsyndromic cleft lip with or without cleft palate in a Chinese population.

  9. The IRF6 AP-2a binding site promoter polymorphism is associated with isolated oral clefts in Latvia.

  10. genetic polymorphism of the IRF6 gene is associated with increased risk of nsCLP in a Xinjiang Uyghur population.

Zebrafish Interferon Regulatory Factor 6 (IRF6) interaction partners

  1. Fish IRF6 is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (show MYD88 ELISA Kits) and TBK1 (show TBK1 ELISA Kits), suggesting that differences in the IRF6 regulation pattern exist between lower and higher vertebrates.

  2. Authors report that Kruppel-like factor 17 (Klf17 (show KLF17 ELISA Kits)), like Grhl3 (show GRHL3 ELISA Kits), acts downstream of Irf6 in this network in zebrafish periderm.

  3. In zebrafish periderm, grainyhead-like 3 (grhl3 (show GRHL3 ELISA Kits)) (an ancient regulator of the epidermal permeability barrier), was identified as acting downstream of Irf6. Simultaneous inhibition of grhl1 (show GRHL1 ELISA Kits) and grhl3 (show GRHL3 ELISA Kits) disrupted periderm differentiation in zebrafish.

  4. analysis of zebrafish expression of IRF6

  5. These experiments reveal a conserved role for maternally-encoded Irf6 in differentiation of a simple epithelium in X. laevis and D. rerio.

Mouse (Murine) Interferon Regulatory Factor 6 (IRF6) interaction partners

  1. These data provide the first mechanistic insight into the heightened caries susceptibility associated with CLP (show HAPLN1 ELISA Kits) and indicate a direct role for the major CLP (show HAPLN1 ELISA Kits) gene Irf6 in salivary gland development and a significant role in regulating oral immunity in mice.

  2. that downregulation of interferon regulatory factor 6 affords protection against TNI (show TNNI2 ELISA Kits) through Akt (show AKT1 ELISA Kits)-eNOS (show NOS3 ELISA Kits) pathway-mediated antioxidative and anti-inflammatory activity

  3. Irf6 is required for resistance to Lipopolysaccharides-induced endotoxic shock. In addition, Irf6-deficient bone marrow-derived neutrophils exhibited increased chemotactic index and velocity compared with wild-type cells in vitro.

  4. TGFbeta3 increases IRF6 expression and subsequently regulates SNAI2 (show SNAI2 ELISA Kits) expression; IRF6 appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2 (show SNAI2 ELISA Kits).

  5. Pvrl1 (show PVRL1 ELISA Kits) is a bona fide target gene of the transcription factor p63 (show CKAP4 ELISA Kits), whereas Pvrl4 (show PVRL4 ELISA Kits) regulation is linked to epidermal differentiation and is under Irf6

  6. Data suggest that Irf6 functions through the RhoA (show RHOA ELISA Kits) pathway to regulate cellular migration.

  7. These results support a role for IRF6 in brain morphometry and provide evidence for a potential genetic link to abnormal brain development in orofacial clefting.

  8. Irf6 plays important cell-autonomous and non-cell-autonomous roles in muscular differentiation and cytoskeletal formation in the tongue.

  9. Irf6 plays a critical role in regulating epithelial invagination

  10. IRF6 and SMAD4 (show SMAD4 ELISA Kits) synergistically regulate the fate of the medial edge epithelium (MEE), and TGFbeta (show TGFB1 ELISA Kits)-mediated Irf6 activity is responsible for MEE degeneration during palatal fusion in mice.

IRF6 Antigen Profile

Antigen Summary

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with IRF6

  • interferon regulatory factor 6 (IRF6) antibody
  • interferon regulatory factor 6 (irf6) antibody
  • interferon regulatory factor 6 (Irf6) antibody
  • AI876454 antibody
  • DKFZp469E012 antibody
  • E230028I05Rik antibody
  • IRF6 antibody
  • LPS antibody
  • mirf6 antibody
  • OFC6 antibody
  • PIT antibody
  • PPS antibody
  • PPS1 antibody
  • VWS antibody
  • VWS1 antibody
  • xIRF-6 antibody
  • zgc:63500 antibody

Protein level used designations for IRF6

interferon regulatory factor 6 , interferon regulatory factor 6-like , IRF-6

GENE ID SPECIES
443083 Ovis aries
457701 Pan troglodytes
594908 Xenopus (Silurana) tropicalis
712958 Macaca mulatta
100174467 Pongo abelii
100402804 Callithrix jacchus
100594750 Nomascus leucogenys
3664 Homo sapiens
393570 Danio rerio
443771 Xenopus laevis
480015 Canis lupus familiaris
397521 Sus scrofa
614253 Bos taurus
54139 Mus musculus
364081 Rattus norvegicus
100349520 Oryctolagus cuniculus
419863 Gallus gallus
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