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Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Additionally we are shipping IRF8 Antibodies (102) and IRF8 Kits (3) and many more products for this protein.
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Study reveals that specification of all macrophages requires irf8 during an early period of zebrafish hematopoiesis but not during the adult-phase. Also, Irf8 seems to have essential roles in host defense as well.
Irf8 is a critical determinant for neutrophil versus macrophage fate choice during zebrafish primitive myelopoiesis.
IRF5 (show IRF5 Proteins) and IRF8, two transcription factors with opposing functions, control TLR9 (show TLR9 Proteins) signaling in human plasmacytoid dendritic cells.
cytarabine-induced upregulation of the IRF8 in leukemic cells involves increased levels of ZNF224 (show ZNF224 Proteins), which can counteract the repressive activity of WT1 (show WT1 Proteins) on the IRF8-promoter
Expression of WT1and IRF8 showed a moderate inverse correlation in acute myeloid leukemia (show BCL11A Proteins) patients. WT1 (show WT1 Proteins) can be used as an minimal residual disease marker, especially in patients without recurrent genetic abnormalities.
Results show that IRF8 is a possible genetic variant associated with the development of HT and production of thyroid antibody
The IRF8 gene variant influenced the interaction between IRF8 and NF-kappaB (show NFKB1 Proteins) and thus susceptibility to systemic sclerosis.
This article provides an overview of recent advances in our understanding of the role of IRF8 in myelopoiesis and related diseases. [review]
This study demonstrated that the Polymorphism, Single Nucleotide of IRF8 is associated with multiple sclerosis in woman in Russia.
gene variants in IRF5 (show IRF5 Proteins), IRF8 and GPC5 (show GPC5 Proteins) were not associated with risk of relapse or disease progression in multiple sclerosis
Irf8 forms a negative feedback loop with Cebpb (show CEBPB Proteins), a monocyte-derived DC epigenetic fate-determining transcription factor.
MN1 (show MN1 Proteins) prevents activation of the immune response pathway, and suggest restoration of IRF8 signaling as therapeutic target in AML (show RUNX1 Proteins)
direct the expression of a set of genes, the IRF8/IRF1 (show IRF1 Proteins) regulome, that play critical roles in host inflammatory and antimicrobial defenses in mouse models of neuroinflammation and of pulmonary tuberculosis, respectively
we identified IRF8 target genes in gastric epithelial cells, providing a detailed understanding of how IRF8 functions in gastric mucosal innate immunity
results suggest that impaired Icsbp expression enhances leukemogenesis by deregulating processes that normally limit granulocyte expansion during the innate immune response.
variation in IRF4 (show IRF4 Proteins) or IRF8 levels resulting from genetic polymorphisms or environmental cues will govern tissue dendritic cells numbers and regulate the magnitude of their functional responses.
Data indicate that interferon regulatory factor-8 (IRF8) regulates tumor behavior in an matrix metalloproteinase 3 (MMP3 (show MMP3 Proteins))-dependent manner.
Data indicate that interferon (show IFNA Proteins) regulatory factors IRF4 (show IRF4 Proteins) and IRF8 control distinct activated B cell states.
dendritic cells from mice with CD11c (show ITGAX Proteins)-specific constitutive b-catenin activation upregulated IRF8 through targeting of the Irf8 promoter, leading to in vivo expansion of IRF8-dependent CD8alpha+, plasmacytoid, and CD103 (show ITGAE Proteins)+ CD11b2 dendritic cells.
IRF8 not only bestows monocyte and DC differentiation potential upon mononuclear phagocyte progenitors but also restrains these progenitors from differentiating into neutrophils in a process involving C-EBPalpha (show CEBPA Proteins)
Loss of IRF8 in T Cells Exacerbates Uveitis, Whereas Irf8 Deletion in the Retina Confers Protection
Data show that IRF8 directly interacts with NFATc1 (show NFATC1 Proteins) to prevent NFATc1 (show NFATC1 Proteins) translocation and thus inhibits the hypertrophic response.
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection.
, interferon regulatory factor 8
, interferon regulatory factor 8-like
, interferon consensus sequence binding protein 1
, interferon consensus sequence-binding protein
, transcription factor ICSBP
, interferon consensus sequence binding protein