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Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Additionally we are shipping ISG20 Antibodies (53) and ISG20 Kits (3) and many more products for this protein.
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Variation at rs12913965 may affect the risk for shoulder dislocation by affecting the activity of either TICRR or ISG20.
We discovered two genome-wide significant SNPs. The first was novel and near ISG20. The second was in TRIOBP, a gene previously associated with prelingual nonsyndromic hearing loss. Motivated by our TRIOBP results, we also looked at exons in known hearing loss genes, and identified two additional SNPs, rs2877561 in ILDR1 (show ILDR1 Proteins) and rs9493672 in EYA4 (show EYA4 Proteins) (at a significance threshold adjusted for number of SNPs in those regions).
these data provide a detailed explanation for the specific antiviral action of ISG20 and suggest that ISG20 may act as a promising antiviral drug candidate against IAV.
The results suggest that hantavirus infection interferes with DAXX (show DAXX Proteins)-mediated apoptosis, and expression of interferon-activated (show MNDA Proteins) Sp100 (show SP100 Proteins) and ISG-20 proteins may indicate intracellular intrinsic antiviral attempts.
ISG20 inhibited infections by hepatitis C virus, bovine viral diarrhea virus and hepatitis A virus. Moreover, ISG20 demonstrated cell-type specific antiviral activity against yellow fever virus, a classical flavivirus.
ISG20has distinctive residues, Met14 and Arg53, to accommodate hydrogen bonds with the 2'-OH group of the UMP ribose, and these residues may be responsible for the preference of ISG20 for RNA substrates
ISG20 has a role in reducing the synthesis of HBV proteins
Suggest that the recruitment of peripheral CXCR4 (show CXCR4 Proteins)-expressing ITGA2 (show ITGA2 Proteins)(+)ISG20(+) NK cells into pregnant uteri may be important in the regulation of feto-maternal tolerance.
Exonuclease with specificity for single-stranded RNA and, to a lesser extent for DNA. Degrades RNA at a rate that is approximately 35-fold higher than its rate for single-stranded DNA. May be involved in the antiviral function of IFN against RNA viruses (By similarity). Besides its function in antiviral defense, ISG20 may play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (By similarity).
interferon stimulated exonuclease gene 20kDa
, interferon stimulated exonuclease 20
, interferon stimulated gene 20kDa
, interferon-stimulated gene 20 kDa protein
, interferon-stimulated protein
, estrogen-regulated transcript 45 protein
, promyelocytic leukemia nuclear body-associated protein ISG20
, interferon stimulated exonuclease