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Interferon-Induced Protein with Tetratricopeptide Repeats 1 Proteins (IFIT1)

IFIT1 encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. Additionally we are shipping IFIT1 Antibodies (35) and IFIT1 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat IFIT1 IFIT1 294090  
IFIT1 3434 P09914
IFIT1 15957 Q64282
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Top IFIT1 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,349.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

IFIT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1) Interaction Partners

Human Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1) interaction partners

  1. Data show that interferon (show IFNA Proteins)-induced proteins with tetratricopeptide repeats 1 and 2 (IFIT1 and IFIT2 (show IFIT2 Proteins)) contribute to the regulation of hepatitis B virus (HBV) replication, likely at both transcriptional and posttranscriptional steps.

  2. IFIT1 is not a dominant restriction factor against three different families of negative-sense RNA viruses.

  3. Reovirus T3D infection induced STAT-1, ISG-15, IFIT-1, Mx1, and IFIT-3 expression.

  4. The specificity of IFIT1 for 2'O-unmethylated RNA serves as potent antiviral mechanism against viruses lacking 2'O-methyltransferase activity and at the same time allows unperturbed progression of the antiviral program in infected cells.

  5. TLR4 (show TLR4 Proteins) signaling, induced by LPS (show IRF6 Proteins), increases the expression of melanoma differentiation-associated gene 5 (MDA5 (show IFIH1 Proteins)) and interferon (show IFNA Proteins)

  6. ISG56 may play a role in immune and inflammatory reactions induced by toll-like receptor 3 (show TLR3 Proteins) signaling in human mesangial cells.

  7. Results indicate that miR (show MLXIP Proteins)-203 is an interferon (show IFNA Proteins)-inducible miRNA that can negatively regulate a number of cellular mRNAs, including an interferon (show IFNA Proteins)-stimulated gene target, IFIT1/ISG56, by destabilizing its mRNA transcript.

  8. Data suggested that PIV5 mRNAs are methylated at the 2'-hydroxyl group and that ISG56/IFIT1 inhibits the translation of PIV5 mRNA by some unrecognized mechanism. Also ISG56/IFIT1 is primarily responsible for the IFN-induced inhibition of PIV5.

  9. crystal structures of human IFIT5, its complex with PPP-RNAs, and an amino-terminal fragment of IFIT1

  10. Hepatitis C virus infection suppresses the upregulation of a subset of effector molecules, including ISG56 and IFITM1 (show IFITM1 Proteins).

Mouse (Murine) Interferon-Induced Protein with Tetratricopeptide Repeats 1 (IFIT1) interaction partners

  1. Data suggest that, with up-regulation of IFIT1, alphaviruses (Venezuelan equine encephalitis virus; Chikungunya virus) with wild-type 5' untranslated regions are inducers of type I IFN (interferon (show IFNA Proteins)), suggesting a new mechanism of type I IFN induction.

  2. Targeted expression of Ifit1 in hepatocytes protects mice from lipopolysaccharide and D-galactosamine induced lethal hepatitis.

  3. IFIT1 is not a dominant restriction factor against three different families of negative-sense RNA viruses.

  4. The specificity of IFIT1 for 2'O-unmethylated RNA serves as potent antiviral mechanism against viruses lacking 2'O-methyltransferase activity and at the same time allows unperturbed progression of the antiviral program in infected cells.

  5. Thus, Ifit1 inhibits replication of MTase (show DNMT1 Proteins)-defective Japanese encephalitis virus by inhibiting mRNA translation through direct binding to mRNA 5' structures.

  6. Study identified Ifit1 as an important innate immune bottleneck.

  7. results suggest that virulent strains of West Nile virus have largely evaded the antiviral effects of Ifit1, and viral mutants lacking 2'-O methylation are controlled in vivo by Ifit1-dependent and -independent mechanisms in different cell types

  8. IFIT1 bound PPP-RNA antagonizes viruses by sequestering specific viral nucleic acids.

  9. Under some stressful stimulations IFIT1 may participate in cell death pathways by interaction with eEF1A (show EEF1A2 Proteins).

  10. block different functions of eIF3 (show EIF3A Proteins) by binding to its different subunits.

IFIT1 Protein Profile

Protein Summary

This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed.

Gene names and symbols associated with IFIT1

  • interferon-induced protein with tetratricopeptide repeats 1-like B (Ifit1lb)
  • interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)
  • interferon-induced protein with tetratricopeptide repeats 1 (ifit1)
  • interferon-induced protein with tetratricopeptide repeats 1 (Ifit1)
  • C56 protein
  • DKFZp469C2331 protein
  • G10P1 protein
  • Garg16 protein
  • IFI-56 protein
  • IFI-56K protein
  • Ifi56 protein
  • IFIT-1 protein
  • Ifit1 protein
  • IFNAI1 protein
  • ISG56 protein
  • P56 protein
  • RNM561 protein

Protein level used designations for IFIT1

interferon-induced protein with tetratricopeptide repeats 1 , interferon-induced protein with tetratricopeptide repeats 5-like , interferon-induced protein with tetratricopeptide repeats 1-like , interferon, alpha-inducible protein (MW 56kD) , interferon-induced 56 kDa protein , interferon-inducible mRNA 561 , GARG-16 , IFI-56K , IFIT-1 , glucocorticoid-attenuated response gene 16 protein , glucocorticoid-attenuated response gene 16 product , interferon-induced protein with tetratricopeptide repeats 1-like protein

GENE ID SPECIES
294090 Rattus norvegicus
450587 Pan troglodytes
488947 Canis lupus familiaris
495383 Xenopus laevis
695683 Macaca mulatta
100058990 Equus caballus
100139670 Bos taurus
100173806 Pongo abelii
100216071 Xenopus (Silurana) tropicalis
100406756 Callithrix jacchus
100475782 Ailuropoda melanoleuca
100585530 Nomascus leucogenys
3434 Homo sapiens
15957 Mus musculus
56824 Rattus norvegicus
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