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IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Additionally we are shipping IFITM1 Antibodies (106) and many more products for this protein.
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These results indicate that IFITM1 protein can restrict alphavirus infection by inhibiting viral fusion with cellular membranes.
The transcriptional regulation of IFITM1, 2 and 3 expression.
IFITM1 and IFITM3 (show IFITM3 Proteins) inhibit Zika virus infection early in the viral life cycle.
IFITM1 suppression blocks proliferation and invasion of aromatase (show CYP19A1 Proteins) inhibitor-resistant breast cancer in vivo by JAK (show JAK3 Proteins)/STAT1 (show STAT1 Proteins)-mediated induction of p21 (show CDKN1A Proteins).
Compared with CD10 (show MME Proteins), IFITM1 has superior performance distinguishing endometrial stroma of adenomyosis from mesenchyma surrounding invasive endometrial adenocarcinoma.
Overexpression of IFITM1 is associated with Oral Squamous Cell Carcinomas.
High expression of IFITM1 is associated with poor prognosis of colorectal cancer.
These findings indicate that overexpression of IFITM1 enhances the aggressive phenotype of triple-negative SUM149 IBC cells and that this effect is dependent on STAT2 (show STAT2 Proteins)/BRG1 (show SMARCA4 Proteins) interaction.
the importance of the C-terminal region of IFITM1 in modulating the antiviral function through controlling protein subcellular localization.
Suggest that IFITM1 promotes the aggressiveness of colorectal cancer cells via caveolin-1 (show CAV1 Proteins) signaling.
ZMPSTE24 (show Zmpste24 Proteins) is a downstream effector of IFITM3 (show IFITM3 Proteins) and is important for interferon (show IFNA Proteins)-induced transmembrane antiviral activity.
IFITM3 (show IFITM3 Proteins) represents a checkpoint regulator of antiviral immunity that controls cytokine production to restrict viral pathogenesis.
Collectively, the data define an antiviral role for Ifitm3 (show IFITM3 Proteins) in restricting infection of multiple alphaviruses.
Ifitm3 (show IFITM3 Proteins) plays a role in mouse primordial germ cell homing and repulsion by enhancing the regionalization of PGCs.
Ifitm3 (show IFITM3 Proteins) does not impact on the restriction or pathogenesis of bacterial (Salmonella typhimurium, Citrobacter rodentium, Mycobacterium tuberculosis) or protozoan (Plasmodium berghei) pathogens, despite in vitro evidence.
results suggest that modification of Tyr (show TYR Proteins)(20) may serve in a cellular checkpoint controlling IFITM3 (show IFITM3 Proteins) trafficking and degradation and demonstrate the complexity of posttranslational regulation of IFITM3 (show IFITM3 Proteins)
Interferon-induced transmembrane protein 3 (show IFITM3 Proteins) is a type II transmembrane protein (show SLC3A2 Proteins).
results revealed diverse, yet consistent, profiles of IFITM3 (show IFITM3 Proteins) localization throughout the gastrula
IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53- dependent manner. Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals.
interferon induced transmembrane protein 1 (9-27)
, interferon-induced transmembrane protein 1
, interferon induced transmembrane protein 1
, dispanin subfamily A member 2a
, interferon-induced protein 17
, interferon-inducible protein 9-27
, leu-13 antigen
, fragilis protein 2
, ifitm-like protein 2
, interferon induced transmembrane protein 2 like
, dispanin subfamily A member 2b
, fragilis protein
, ifitm-like protein 1
, interferon-induced transmembrane protein 3
, interferon-inducible protein 15