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The protein encoded by IL10RA is a receptor for interleukin 10. Additionally we are shipping IL10RA Antibodies (181) and IL10RA Kits (18) and many more products for this protein.
Showing 10 out of 13 products:
genetic association study in cohort of infants/children: Data suggest perianal fistulas are exhibited in patients with very early-onset inflammatory bowel disease with IL10 (show IL10 Proteins) receptor mutations (IL10RA/B); prognosis and response to treatment are poor.
IL-10Ralpha expression is post-transcriptionally regulated by miR (show MLXIP Proteins)-15a, miR (show MLXIP Proteins)-185, and miR (show MLXIP Proteins)-211 in melanoma
We also observed that BM-MSCs upregulated IL-10 (show IL10 Proteins) secretion as well as the expression of its receptor CD210 on T cells, thus creating a loop favoring the expansion of IL-10 (show IL10 Proteins)-producing T cells
SNP3 polymorphism is associated with myocardial infarction; may generate some conformational rearrangements of the IL-10R1 receptor domain which affects IL-10 (show IL10 Proteins) complex binding and alters its downstream signal
High IL10RA expression is associated with diffuse large B-cell lymphoma.
Data suggest that, compared with monocytes and macrophages, myeloid dendritic cells partially escape from IL-10 (show IL10 Proteins)'s inhibitory mechanisms by downregulating IL-10R1.
Inflammatory bowel disease (IBD) in infancy is phenotypically and genetically different disease entity from adult-onset or older child-onset IBD. It has a strong association with IL-10 (show IL10 Proteins) receptor gene.
IL10R1 loss-of-function A536/S138G polymorphism may contribute to recurrent pregnancy loss pathogenesis
Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation.
No evidence for an involvement of autoantibodies against IL-10 (show IL10 Proteins) or IL-10R in the pathogenesis of inflammatory bowel disease could be established.
loss of IL-10R signaling impaired the generation and function of anti-inflammatory intestinal and bone-marrow-derived macrophages and their ability to secrete IL-10 (show IL10 Proteins).
loss of IL-10 (show IL10 Proteins) receptor expression impaired the critical conditioning of monocyte-derived macrophages and resulted in spontaneous development of severe colitis.
Recent findings review how IL10 (show IL10 Proteins)- and IL10R-dependent signaling modulates innate and adaptive immune responses in the murine intestine.
Treatment of mice with rIFN-gamma was sufficient to drive expression of IL-10R1 in the colonic epithelium. Intestinal epithelial-specific IL-10R1-null mice were more susceptible to DSS (show PMP22 Proteins) colitis associated with increased intestinal permeability.
Inhibition of IL-10R signaling during bacillus Calmette-Guerin (BCG (show SLC11A1 Proteins)) vaccination increases and balances IFN-gamma (show IFNG Proteins) and IL-17A (show IL17A Proteins) responses in favor of the host.
IL-10R subunit-alpha signaling plays a key role in the development as well as B-cell help function of T (follicular helper) cells in vitro and in vivo.
showed here that IL-17A (show IL17A Proteins)-producing CD4 (show CD4 Proteins)+ T cells expressed interleukin-10 receptor alpha (IL-10Ralpha) in vivo
Data show that, in an IL-10 (show IL10 Proteins)-dependent LPS (show TLR4 Proteins) model of endotoxemia, dampening of the immune response requires expression of IL-10R1 in monocytes/macrophages and/or neutrophils but not in T cells nor B cells.
reversal of tumor-induced dendritic cell paralysis by CpG immunostimulatory oligonucleotide and anti-interleukin 10 receptor (show IL10RB Proteins) antibody
Immunocytochemistry data shows that the region of the adrenal gland responsible for the vast majority of corticosterone synthesis, the zona fasciculata, predominantly expresses the IL-10 (show IL10 Proteins) receptor 1.
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
interleukin 10 receptor 1
, interleukin-10 receptor subunit alpha
, interleukin 10 receptor, alpha
, interleukin-10 receptor subunit alpha-like
, IL-10 receptor subunit alpha
, IL-10R subunit 1
, IL-10R subunit alpha
, interleukin-10 receptor alpha chain
, interleukin-10 receptor subunit 1