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IL17RC encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Additionally we are shipping Interleukin 17 Receptor C Antibodies (80) and Interleukin 17 Receptor C Kits (9) and many more products for this protein.
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human IL-17RC is essential for mucocutaneous immunity to C. albicans but is otherwise largely redundant.
results suggested a potential involvement of IL-17RC+CD8 (show CD8A Proteins)+ T cells in pathogenesis of ocular sarcoidosis
IL-17RC predisposes to the development of adolescent idiopathic scoliosis in a Chinese Han population.
Data show that IL-17RA (show IL17RA Proteins), IL-17RC, IL-22R1, ERK1/2 MAPK (show MAPK1 Proteins) and NF-kappaB (show NFKB1 Proteins) pathways are involved in Th17 cytokine-induced proliferation.
Overall, our study found a significant association of IL-17RC gene polymorphisms with AIS (show AR Proteins) in a Chinese Han population, indicating IL-17RC gene may be as a susceptibility gene for AIS (show AR Proteins).
IL-17 (show IL17A Proteins) and its receptor IL-17RC are involved in rheumatoid arthritis synovial fluid-mediated chemotaxis in human lung microvascular endothelial cell culture.
IL-17RL exists as multiple isoforms due to extensive alternative splicing. Changes in RNA IL-17RL splicing occur in advanced cancers.
The biologic activity of IL-17 (show IL17A Proteins) is dependent on a complex composed of receptors IL-17RA (show IL17RA Proteins) and IL-17RC.
IL-17RC functions as a receptor for both IL-17A (show IL17A Proteins) and IL-17F (show IL17F Proteins); a soluble version of this protein should be an effective antagonist of IL-17A (show IL17A Proteins) and IL-17F (show IL17F Proteins) mediated inflammatory diseases.
IL-17A (show IL17A Proteins)-induced IL-6 (show IL6 Proteins), IL-8 (show IL8 Proteins), and CCL20 (show CCL20 Proteins) secretion was dependent on both IL-17RA (show IL17RA Proteins) and IL-17RC, which are overexpressed in RA patients.
Interleukin-17 receptor C deficient mice had higher rates of apoptosis in castration-resistant prostate cancer.
Data show that signaling in IL-17RC(-/-) fibroblasts required the SEF (show IL17RD Proteins)/IL-17R signaling domain (SEFIR).
IL-17RC is essential for mediating the functions of IL-17A (show IL17A Proteins), IL-17F (show IL17F Proteins), and IL-17A (show IL17A Proteins)/F both in vitro and in vivo and directly participates in the pathogenesis of central nervous system inflammation.
This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
interleukin 17 receptor C
, interleukin-17 receptor C
, interleukin-17 receptor C-like
, IL-17 receptor C
, IL17F receptor
, interleukin-17 receptor homolog
, interleukin-17 receptor-like protein