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The protein encoded by IL18 is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Additionally we are shipping IL 18 Antibodies (217) and IL 18 Kits (109) and many more products for this protein.
Showing 10 out of 66 products:
Human IL 18 Protein expressed in Escherichia coli (E. coli) - ABIN413464
Kahlenberg, Thacker, Berthier, Cohen, Kretzler, Kaplan: Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. in Journal of immunology (Baltimore, Md. : 1950) 2011
Show all 4 references for ABIN413464
Human IL 18 Protein expressed in Escherichia coli (E. coli) - ABIN666748
Yoshimoto, Takeda, Tanaka, Ohkusu, Kashiwamura, Okamura, Akira, Nakanishi: IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. in Journal of immunology (Baltimore, Md. : 1950) 1998
Show all 3 references for ABIN666748
Mouse (Murine) IL 18 Protein expressed in Escherichia coli (E. coli) - ABIN2007275
Liew, McInnes: Role of interleukin 15 and interleukin 18 in inflammatory response. in Annals of the rheumatic diseases 2002
GABA-B receptor antagonists reduced Il18 levels in male mice and increased Il18 levels in female mice following neonatal hypoxia ischemia.
NLRP1 is an innate immune sensor that functions in the context of metabolic stress to produce IL-18, preventing obesity and metabolic syndrome.
IL-18 is sufficient to protect Birc3 (show BIRC3 Proteins)-deficient mice from sodium dodecyl sulfate-induced colitis.
IL-18 plays a facilitative role via NF-kappaB (show NFKB1 Proteins) activation in pulmonary hypertension formation.
IL-18 is a key epithelial-derived cytokine that differentially regulates distinct subsets of intestinal CD4 (show CD4 Proteins)(+) T cells during both homeostatic and inflammatory conditions
Genetic ablation of IL-18 does not protect mice against maladaptive right ventricular remodeling following exposure to hypobaric hypoxia.
We conclude that in the systemic lupus erythematosus syndrom IL-18 is involved specifically in the renal pathogenesis
These results uncover the direct role of IL-18 in promoting goblet cell dysfunction during colitis, leading to breakdown of the mucosal barrier.
IL-18 is a potent stimulator of Chi3l1 (show CHI3L1 Proteins) and that Chi3l1 (show CHI3L1 Proteins) is an important mediator of IL-18-induced inflammatory, fibrotic, alveolar remodeling, and cytotoxic responses.
macrophages are not involved in IL-18-mediated susceptibility to L. amazonensis.
Study reports that the monocyte-derived cytokines IL-12 (show IL12A Proteins) and IL-18 act synergistically on porcine gammadelta T cells to induce IFN-gamma (show IFNG Proteins) production. Additional stimuli such as the mitogen ConA and IL-2 (show IL2 Proteins) are necessary to activate the cells for enhanced proliferation.
IL-18 concentration in saliva (show RAG1AP1 Proteins) was significantly increased during a 60-min acute immobilization stress in thirteen 5-month-old pigs. These results are the first evidence of a stress-related change of IL-18 in pig saliva (show RAG1AP1 Proteins).
endometrial expression of CASP1 (show CASP1 Proteins) and IL18 associated with pregnancy establishment; alteration of CASP1 (show CASP1 Proteins) and IL18 following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy
Porcine IL-18 regulates anti-pig cellular rejection in C57BL/6 mice.
Significant associations were detected between the IL-18 rs187238(G/C) polymorphism and chronic leukemia. The CC genotype may be associated with the risk of CLL. There were no significant associations between the IL-18 rs61667799(G/T), rs5744227(C/G), or rs5744228(A/G) polymorphisms and CLL or CML.
Older T2DM patients carrying the C allele of IL-18 G(-137)C polymorphism have a significantly increased risk of CVD.
Data suggest that nonlinear resistance training or aerobic interval training for 12 weeks produces no significant changes in serum levels of omentin (show ITLN1 Proteins)-1 and interleukin-18 in obese men; however, during a 4-week detraining period, omentin (show ITLN1 Proteins)-1 decreases significantly and IL-18 increases significantly.
This study aims at investigating whether TNFA (show TNF Proteins) -308 G/A and IL18 -137 G/C and -607 C/A polymorphisms are associated with susceptibility to HPV infection/progression to high-grade squamous intraepithelial lesion.
no confirmatory evidence for the hypothesis of IL-10 (show IL10 Proteins) and IL-18 alleles modulating the risk of cognitive impairment in Chinese Parkinson's disease patients was obtained.
Kaplan-Meier analysis evidenced a weak effect of IL-18-137G/C genotypes on graft survival after kidney transplantation.
We conclude that IL-17A (show IL17A Proteins) is a previously unrecognized effector of IL-18-mediated injury in neonatal sepsis and that disruption of the deleterious and tissue-destructive IL-18/IL-1 (show IL1A Proteins)/IL-17A (show IL17A Proteins) axis represents a novel therapeutic approach to improve outcomes for human neonates with sepsis.
The IL-18 -137 G/C polymorphism was significantly associated with an increased risk of recurrent pregnancy loss under a recessive genetic model. For the -607C/A mutation, no association was found under any genetic models.
Cancer cells can produce IL-18, which is involved in the process of angiogenesis, stimulates invasion and metastasis. Decrease in SIPA for the production of IL-6 (show IL6 Proteins) and GCSF (show CSF3 Proteins) by peripheral blood cells could serve as an indicator of malignant progression in invasive ductal breast carcinoma.
IL-18 is associated with insulin (show INS Proteins) resistance and other cardiovascular risk factors; the CC genotype of the rs1834481 SNP of the IL-18 gene was significantly associated with lower levels of IL-18; the GG genotype of the rs7559479 SNP was associated with significant higher levels of IL-18
These results suggest that BAPC-1 is a stem/progenitor cell line and modulates the immuno-endocrine function of the anterior pituitary cells through its production of interleukin-18 and the IL-18 receptor.
Pressure overload, while enhancing IL-18 and IL-18R expression in hypertrophied and failing hearts, markedly attenuated the level of expression of the endogenous IL-18 antagonist IL-18BP (show IL18BP Proteins).
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, IL-1 gamma
, interferon gamma-inducing factor
, interferon-gamma-inducing factor
, interleukin-1 gamma
, interferon gamma inducing factor
, Interferon gamma-inducing factor
, interleukin 18
, uncharacterized protein LOC100734451