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The protein encoded by IL18 is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Additionally we are shipping IL 18 Antibodies (221) and IL 18 Kits (127) and many more products for this protein.
Showing 10 out of 75 products:
Human IL 18 Protein expressed in Escherichia coli (E. coli) - ABIN413464
Kahlenberg, Thacker, Berthier, Cohen, Kretzler, Kaplan: Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. in Journal of immunology (Baltimore, Md. : 1950) 2011
Show all 4 references for ABIN413464
Human IL 18 Protein expressed in Escherichia coli (E. coli) - ABIN666748
Yoshimoto, Takeda, Tanaka, Ohkusu, Kashiwamura, Okamura, Akira, Nakanishi: IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. in Journal of immunology (Baltimore, Md. : 1950) 1998
Show all 3 references for ABIN666748
Mouse (Murine) IL 18 Protein expressed in Escherichia coli (E. coli) - ABIN2007275
Liew, McInnes: Role of interleukin 15 and interleukin 18 in inflammatory response. in Annals of the rheumatic diseases 2002
Data, including data from studies in knockout mice, suggest that TNF (tumor necrosis factor (show TNF Proteins)), TNFR1 (show TNFRSF1A Proteins) (TNF (show TNF Proteins) receptor 1), and IL18 (interleukin 18) are involved in liver lipid metabolism. IL18 or TNFR1 (show TNFRSF1A Proteins) knockout mice on chow show higher liver triglyceride deposition than wild-type mice fed chow; in IL18 or TNFR1 (show TNFRSF1A Proteins) knockout mice, high-refined-carbohydrate diet does not lead to fatty liver disease as it does in wild-type mice.
GABA-B receptor antagonists reduced Il18 levels in male mice and increased Il18 levels in female mice following neonatal hypoxia ischemia.
NLRP1 is an innate immune sensor that functions in the context of metabolic stress to produce IL-18, preventing obesity and metabolic syndrome.
IL-18 is sufficient to protect Birc3 (show BIRC3 Proteins)-deficient mice from sodium dodecyl sulfate-induced colitis.
IL-18 plays a facilitative role via NF-kappaB (show NFKB1 Proteins) activation in pulmonary hypertension formation.
IL-18 is a key epithelial-derived cytokine that differentially regulates distinct subsets of intestinal CD4 (show CD4 Proteins)(+) T cells during both homeostatic and inflammatory conditions
Genetic ablation of IL-18 does not protect mice against maladaptive right ventricular remodeling following exposure to hypobaric hypoxia.
We conclude that in the systemic lupus erythematosus syndrom IL-18 is involved specifically in the renal pathogenesis
These results uncover the direct role of IL-18 in promoting goblet cell dysfunction during colitis, leading to breakdown of the mucosal barrier.
IL-18 is a potent stimulator of Chi3l1 (show CHI3L1 Proteins) and that Chi3l1 (show CHI3L1 Proteins) is an important mediator of IL-18-induced inflammatory, fibrotic, alveolar remodeling, and cytotoxic responses.
Study reports that the monocyte-derived cytokines IL-12 (show IL12A Proteins) and IL-18 act synergistically on porcine gammadelta T cells to induce IFN-gamma (show IFNG Proteins) production. Additional stimuli such as the mitogen ConA and IL-2 (show IL2 Proteins) are necessary to activate the cells for enhanced proliferation.
IL-18 concentration in saliva (show RAG1AP1 Proteins) was significantly increased during a 60-min acute immobilization stress in thirteen 5-month-old pigs. These results are the first evidence of a stress-related change of IL-18 in pig saliva (show RAG1AP1 Proteins).
endometrial expression of CASP1 (show CASP1 Proteins) and IL18 associated with pregnancy establishment; alteration of CASP1 (show CASP1 Proteins) and IL18 following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy
Porcine IL-18 regulates anti-pig cellular rejection in C57BL/6 mice.
IL-18 polymorphisms may influence tacrolimus elimination in lung transplantation patients.
Study showed that adipokine leptin (show LEP Proteins) triggered macrophage- related cytokine IL-18 production, possibly contributing to tumor progression in breast cancer cells.
Results provide evidence for IL18-607C/A variation related to the pathogenesis of non-small cell lung cancer in the Chinese population studied.
findings resolve a long-standing contradiction regarding a tumor-suppressive role for IL18 in established hepatocellular carcinoma and provide a mechanistic explanation for the complex relationship between its expression pattern and hepatocellular carcinoma prognosis
IL-18 -372C/G did not contribute to the risk of glioma development in the co-dominant, dominant, and recessive models. Therefore, the IL-18 -607C/A polymorphism was significantly correlated with the risk of Coronary artery disease development.
The IL-18 -607C/A and -137G/C polymorphisms do not influence susceptibility to acute pancreatitis in the Chinese patient cohort.
both ETA and ETB (show EDNRB Proteins) receptor expression in the renal cortex were significantly attenuated by ovariectomy, and this reduction was not evident in OVX+E2 rats. SIGNIFICANCE: These data suggest that ovarian hormones regulate ET receptor expression and may contribute to sex differences in cardiovascular and renal health.
The expression levels of the TNF-alpha (show TNF Proteins), IL-18 and cTnI (show TNNI3 Proteins) and the expression levels of the miR-1 (show FSD1 Proteins) and miR (show MLXIP Proteins)-146b could be used to predict viral myocarditis among children.
The relationship between variants of IL-10 (show IL10 Proteins) and IL-18 in the response to antiviral treatment in hepatitis C patients in Egypt is reported.
Significant associations were detected between the IL-18 rs187238(G/C) polymorphism and chronic leukemia. The CC genotype may be associated with the risk of CLL. There were no significant associations between the IL-18 rs61667799(G/T), rs5744227(C/G), or rs5744228(A/G) polymorphisms and CLL or CML.
These results suggest that BAPC-1 is a stem/progenitor cell line and modulates the immuno-endocrine function of the anterior pituitary cells through its production of interleukin-18 and the IL-18 receptor.
Pressure overload, while enhancing IL-18 and IL-18R expression in hypertrophied and failing hearts, markedly attenuated the level of expression of the endogenous IL-18 antagonist IL-18BP (show IL18BP Proteins).
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, IL-1 gamma
, interferon gamma-inducing factor
, interferon-gamma-inducing factor
, interleukin-1 gamma
, interferon gamma inducing factor
, Interferon gamma-inducing factor
, interleukin 18
, uncharacterized protein LOC100734451