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The protein encoded by IL18BP functions as an inhibitor of the proinflammatory cytokine, IL18. Additionally we are shipping IL18BP Antibodies (110) and IL18BP Kits (31) and many more products for this protein.
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A full-length cDNA of the rhesus IL-18BP (RhIL-18BP) from the spleen of rhesus macaques, was cloned and sequenced.
Pressure overload, while enhancing IL-18 (show IL18 Proteins) and IL-18R expression in hypertrophied and failing hearts, markedly attenuated the level of expression of the endogenous IL-18 (show IL18 Proteins) antagonist IL-18BP.
IL-18BP ameliorates cardiac ischemia/reperfusion injury in part through suppression of Th17 differentiation.
Data show that IL-18bp acts as a sensor for IFN-gamma (show IFNG Proteins) and can regulate both Th1 (show HAND1 Proteins) and Th17 responses in the CNS.
Administratioan of murine IL-18BP at the time of the booster injection of bovine CII reduces the progressive severity of collagen-induced arthritis; both clinical disease activity and histological scores are decreased by 50%.
functional polarization of Ag-specific CD4 (show CD4 Proteins)(+) Th2 cells entering the CNS during the accelerating phase of experimental autoimmune encephalomyelitis is flexible and dependent on IL-18 (show IL18 Proteins), which is overturned by IL-18 (show IL18 Proteins) binding protein
IL-18 (show IL18 Proteins) and IL-18BP may have roles in testicular development, and also in the regulation of testicular functions under physiological conditions
A single intravenous dose of recombinant mouse IL18BP decreased neointimal hyperplasia and improved arterial L/A ratios in an atherosclerotic balloon-injury animal model.
IL-18 (show IL18 Proteins), IL-18R and IL-18BP expression in eosinophil are involved in the inflammatory reaction of asthma.
the inhibition of IL-18 (show IL18 Proteins) signaling by IL-18BPa may be involved in the development of pulmonary vascular involvement leading to pulmonary hypertension and modulate the systemic inflammation in systemic sclerosis
The natural IL-18 (show IL18 Proteins) inhibitor IL-18BP further regulates IL-18 (show IL18 Proteins) activity in the extracellular environment. Review.
imbalance of IL-18/IL-18BP ratio in IgA nephropathy especially in patients with arteriolar lesions
IL-18 (show IL18 Proteins), IL-18BP, and IL-18R may have roles in the pathogenesis of epithelial ovarian carcinoma
HPV16 E7 oncoprotein increases production of the IL18BP in keratinocytes.
these data indicate that IL-18BP, which is produced in EOC in response to microenvironmental factors, may inhibit endogenous or exogenous IL-18 (show IL18 Proteins) activity
Data suggest that the imbalance of IL-18 (show IL18 Proteins)/IL-18BP might play an important role in the pathogenesis of systemic juvenile idiopathic arthritis (SJIA) and it might go hand-in-hand with the severity of SJIA.
Due to highly significant increases in circulating IL-18BP in schizophrenia compared to controls, the levels of free IL-18 (show IL18 Proteins) are not significantly different between schizophrenic groups.
Imbalance between IL-18 (show IL18 Proteins) and IL-18BP may play an important role in pathogenesis of idiopathic thrombocytopenic purpura.
The protein encoded by this gene functions as an inhibitor of the proinflammatory cytokine, IL18. It binds IL18, prevents the binding of IL18 to its receptor, and thus inhibits IL18-induced IFN-gamma production, resulting in reduced T-helper type 1 immune responses. This protein is constitutively expressed and secreted in mononuclear cells. Elevated level of this protein is detected in the intestinal tissues of patients with Crohn's disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
interleukin 18 binding protein
, interferon gamma inducing factor binding protein
, interferon gamma-inducing factor-binding protein
, interleukin-18-binding protein
, MC51L-53L-54L homolog gene product
, interleukin-18 binding protein