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May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. Additionally we are shipping IL26 Antibodies (44) and IL26 Kits (13) and many more products for this protein.
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this study shows that single nucleotide polymorphism near IL-26 gene is associated with familial vitiligo (show MITF Proteins) and existence of halo nevi in Estonian patients
Our study indicates that IL-26 is a potential biomarker of disease severity in pediatric asthma without signs of Th2-mediated inflammation.
IL-26 is emerging as a potentially important player in host defense and may also be a pathogenic factor in the chronic inflammatory disorders of humans. [Review]
The negative influence of IL-26 on the anti-mycobacterial activity and its constitutive presence in both serum and monocyte supernatants prompt a proposal that IL26 as a candidate gene for tuberculosis susceptibility.
IL-26 differentially modulates the infection by different enveloped viruses.
Elevated levels of IL-26 in human gastric cancer promote proliferation and survival by modulating STAT1 (show STAT1 Proteins)/STAT3 (show STAT3 Proteins) signaling.
IL-26 appears as a novel proinflammatory cytokine, located upstream of the proinflammatory cascade, that may constitute a promising target to treat rheumatoid arthritis and chronic inflammatory disorders.
Identify a second enhancer element positioned between IL26 and IFNG required for both IL26 and IFNG expression. One function of this enhancer is to facilitate recruitment of RNA polymerase II to promoters of both genes.
common polymorphisms in the IFNgamma/IL-26 gene region may contribute to sex bias in susceptibility to rheumatoid arthritis, by distorting the propensity of female carriers versus male carriers to contract this disease.
The active receptor complex for IL-26 is a heterodimer composed of two receptor proteins: IL-20 (show IL20 Proteins) receptor 1 and IL-10 (show IL10 Proteins) receptor 2. Signaling through the IL-26 receptor results in activation of STAT1 (show STAT1 Proteins) and STAT3 (show STAT3 Proteins).
Expression analysis of IL-22 (show IL22 Proteins), IL-26 and two IFN-gamma (show IFNG Proteins) genes suggests an active role of these genes in immune responses in fish.
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
, interleukin 26