anti-Interleukin 27 (IL27) Antibodies

The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Additionally we are shipping IL27 Kits (51) and IL27 Proteins (23) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IL27 246778 Q8NEV9
IL27 365368  
IL27 246779 Q8K3I6
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Top anti-IL27 Antibodies at

Showing 10 out of 165 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB WB Suggested Anti-IL27 AntibodyTitration: 1.0 µg/mL <br /> Positive Control: Fetal Lung 100 μL Log in to see 2 to 3 Days
Mouse Rat Un-conjugated WB 25 μL Log in to see 1 to 2 Days
Human Mouse Un-conjugated CyTOF, FACS Detection of IL-27 in PHA + IL-2-treated Human PBMC by Flow Cytometry. Human PBMC, treated with 5 ug/mL PHA and 5 ng/mL rhIL-2 (dark orange filled histogram), or untreated (open histogram, yellow line) were stained with Mouse Anti-Human IL-27 Monoclonal Antibody. To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin. 100 μg Log in to see 8 to 9 Days
Human Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 7 to 9 Days
Mouse Rabbit Biotin WB   100 μg Log in to see 1 to 2 Days
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Spleen, Neutrophils (formalin-fixed, paraffin-embedded) stained with IL27 antibody ABIN351442 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated ICC, IHC (p), WB Human Lung (formalin-fixed, paraffin-embedded) stained with IL27 antibody ABIN337287 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 7 to 9 Days
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC, WB 100 μL Log in to see 16 Days

IL27 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) , , , ,
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Top referenced anti-IL27 Antibodies

  1. Mouse (Murine) Monoclonal IL27 Primary Antibody for ICS, Neut - ABIN2689756 : Hall, Silver, Hunter: The immunobiology of IL-27. in Advances in immunology 2012 (PubMed)
    Show all 7 Pubmed References

  2. Mouse (Murine) Monoclonal IL27 Primary Antibody for WB - ABIN1043835 : Murugaiyan, Mittal, Weiner: Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

  3. Mouse (Murine) Polyclonal IL27 Primary Antibody for WB - ABIN1043831 : Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. in Immunity 2002 (PubMed)

  4. Human Monoclonal IL27 Primary Antibody for CyTOF, FACS - ABIN4900122 : Seyerl, Kirchberger, Majdic, Seipelt, Jindra, Schrauf, Stöckl: Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. in European journal of immunology 2010 (PubMed)

More Antibodies against IL27 Interaction Partners

Human Interleukin 27 (IL27) interaction partners

  1. Expression of IL-27 in the serum was markedly increased in patients with sepsis-induced myo (show IRF6 Antibodies)cardial dysfunction compared with that in controls.

  2. IL-27 significantly inhibited the M2 macrophages polarization and dampened the proliferation, migration and metastasis of pancreatic cancer cells and as well enhanced the efficacy of gemcitabine.

  3. IL-27 increased NLRP3 (show NLRP3 Antibodies) inflammasome activation in monocytes with enhanced release of IL-1 beta (show IL1B Antibodies).

  4. this study shows that interleukin 27 is up-regulated in patients with active inflammatory bowel disease

  5. IL-27 polymorphisms might play a protective role for the development of ulcerative colitis in the Mexican population

  6. IL-27 stimulation activated STAT1 (show STAT1 Antibodies) and STAT3 (show STAT3 Antibodies) in HeLa and T98G cells, suggesting that IL-27 engages the STAT1 (show STAT1 Antibodies)/3 pathway, which then leads to the upregulation of IL-6 (show IL6 Antibodies), IP-10 (show CXCL10 Antibodies), and MIG (show CXCL9 Antibodies)

  7. IL-27 and IL-37 limit the induction of particular T cell subsets along with cytokine responses in S. stercoralis infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helminth infection.

  8. IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th17 cells to produce IL-10 (show IL10 Antibodies).

  9. HIV and Tat (show TAT Antibodies) inhibit LPS (show IRF6 Antibodies)-induced IL-27 production in human macrophages via distinct mechanisms: Tat (show TAT Antibodies) through the inhibition of cIAP-1 (show BIRC2 Antibodies)-TRAF-6 (show TRAF6 Antibodies) and subsequent inhibition of PI3K (show PIK3CA Antibodies) and p38 (show CRK Antibodies) MAPKs, whereas HIV through the inhibition of p38 MAPK (show MAPK14 Antibodies) activation.

  10. IL27 (show EBI3 Antibodies) recapitulates IFN-gamma (show IFNG Antibodies) responses in hepatocellular carcinoma cells, but is inhibited by IL6 (show IL6 Antibodies)-type cytokines.

Mouse (Murine) Interleukin 27 (IL27) interaction partners

  1. Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS (show TLR4 Antibodies) injection compared with control specimens.

  2. these findings highlight critical roles for IFN-gamma (show IFNG Antibodies) and IL-27 in the mechanism of respiratory syncytial virus-induced exacerbation

  3. IL-27-induced Sca-1 (show Ly6a Antibodies)(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes (show EOMES Antibodies) and Blimp1 (show PRDM1 Antibodies).

  4. found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 (show IL6 Antibodies) is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27

  5. We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.

  6. These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.

  7. results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.

  8. These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (show IL1B Antibodies) secretion levels triggered by dual LPS (show TLR4 Antibodies)-ATP stimulation.

  9. findings show that PGE2 inhibits IL-27 production in macrophages and in splenic conventional dendritic cells; and identify a novel pathway consisting of signaling through EP2/EP4-->induction of cAMP-->downregulation of IFN regulatory factor 1 expression and binding to the p28 IFN-stimulated response element site

  10. these data provide the first evidence that IL-27 signals directly to B (show TDO2 Antibodies) cells promote GCs (show UGCG Antibodies) and support the role of IL-27 in lupus.

Pig (Porcine) Interleukin 27 (IL27) interaction partners

  1. The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).

IL27 Antigen Profile

Protein Summary

The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).

Gene names and symbols associated with anti-Interleukin 27 (IL27) Antibodies

  • interleukin 27 (IL27) antibody
  • interleukin 27 (Il27) antibody
  • IL-27 antibody
  • IL-27A antibody
  • IL-27p28 antibody
  • IL27 antibody
  • IL27A antibody
  • IL27p28 antibody
  • Il30 antibody
  • p28 antibody
  • RGD1561420 antibody

Protein level used designations for anti-Interleukin 27 (IL27) Antibodies

IL-27 p28 subunit , IL-27 subunit alpha , IL-27-A , IL27-A , interleukin 30 , interleukin-27 subunit alpha , interluekin 27 , interleukin 27 , interleukin 27 p28 subunit , p28

246778 Homo sapiens
365368 Rattus norvegicus
607880 Canis lupus familiaris
614927 Bos taurus
737725 Pan troglodytes
246779 Mus musculus
493187 Sus scrofa
100724612 Cavia porcellus
101122495 Ovis aries
101093822 Felis catus
Selected quality suppliers for anti-IL27 (IL27) Antibodies
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