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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Additionally we are shipping IL27 Kits (51) and IL27 Proteins (23) and many more products for this protein.
Showing 10 out of 165 products:
Mouse (Murine) Monoclonal IL27 Primary Antibody for ICS, Neut - ABIN2689756
Hall, Silver, Hunter: The immunobiology of IL-27. in Advances in immunology 2012
Show all 7 Pubmed References
Mouse (Murine) Monoclonal IL27 Primary Antibody for WB - ABIN1043835
Murugaiyan, Mittal, Weiner: Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. in Proceedings of the National Academy of Sciences of the United States of America 2010
Mouse (Murine) Polyclonal IL27 Primary Antibody for WB - ABIN1043831
Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. in Immunity 2002
Human Monoclonal IL27 Primary Antibody for CyTOF, FACS - ABIN4900122
Seyerl, Kirchberger, Majdic, Seipelt, Jindra, Schrauf, Stöckl: Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. in European journal of immunology 2010
Expression of IL-27 in the serum was markedly increased in patients with sepsis-induced myo (show IRF6 Antibodies)cardial dysfunction compared with that in controls.
IL-27 significantly inhibited the M2 macrophages polarization and dampened the proliferation, migration and metastasis of pancreatic cancer cells and as well enhanced the efficacy of gemcitabine.
IL-27 increased NLRP3 (show NLRP3 Antibodies) inflammasome activation in monocytes with enhanced release of IL-1 beta (show IL1B Antibodies).
this study shows that interleukin 27 is up-regulated in patients with active inflammatory bowel disease
IL-27 polymorphisms might play a protective role for the development of ulcerative colitis in the Mexican population
IL-27 stimulation activated STAT1 (show STAT1 Antibodies) and STAT3 (show STAT3 Antibodies) in HeLa and T98G cells, suggesting that IL-27 engages the STAT1 (show STAT1 Antibodies)/3 pathway, which then leads to the upregulation of IL-6 (show IL6 Antibodies), IP-10 (show CXCL10 Antibodies), and MIG (show CXCL9 Antibodies)
IL-27 and IL-37 limit the induction of particular T cell subsets along with cytokine responses in S. stercoralis infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helminth infection.
IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th17 cells to produce IL-10 (show IL10 Antibodies).
HIV and Tat (show TAT Antibodies) inhibit LPS (show IRF6 Antibodies)-induced IL-27 production in human macrophages via distinct mechanisms: Tat (show TAT Antibodies) through the inhibition of cIAP-1 (show BIRC2 Antibodies)-TRAF-6 (show TRAF6 Antibodies) and subsequent inhibition of PI3K (show PIK3CA Antibodies) and p38 (show CRK Antibodies) MAPKs, whereas HIV through the inhibition of p38 MAPK (show MAPK14 Antibodies) activation.
IL27 (show EBI3 Antibodies) recapitulates IFN-gamma (show IFNG Antibodies) responses in hepatocellular carcinoma cells, but is inhibited by IL6 (show IL6 Antibodies)-type cytokines.
Serum IL-27 levels and cardiac IL-27 mRNA expression were significantly increased after LPS (show TLR4 Antibodies) injection compared with control specimens.
these findings highlight critical roles for IFN-gamma (show IFNG Antibodies) and IL-27 in the mechanism of respiratory syncytial virus-induced exacerbation
IL-27-induced Sca-1 (show Ly6a Antibodies)(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes (show EOMES Antibodies) and Blimp1 (show PRDM1 Antibodies).
found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 (show IL6 Antibodies) is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27
We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.
These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.
results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (show IL1B Antibodies) secretion levels triggered by dual LPS (show TLR4 Antibodies)-ATP stimulation.
findings show that PGE2 inhibits IL-27 production in macrophages and in splenic conventional dendritic cells; and identify a novel pathway consisting of signaling through EP2/EP4-->induction of cAMP-->downregulation of IFN regulatory factor 1 expression and binding to the p28 IFN-stimulated response element site
these data provide the first evidence that IL-27 signals directly to B (show TDO2 Antibodies) cells promote GCs (show UGCG Antibodies) and support the role of IL-27 in lupus.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interluekin 27
, interleukin 27
, interleukin 27 p28 subunit