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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Additionally we are shipping IL27 Kits (49) and IL27 Proteins (27) and many more products for this protein.
Showing 10 out of 178 products:
Mouse (Murine) Polyclonal IL27 Primary Antibody for EIA, WB - ABIN401111
Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. in Immunity 2002
Mouse (Murine) Monoclonal IL27 Primary Antibody for WB - ABIN1043836
Murugaiyan, Mittal, Weiner: Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. in Proceedings of the National Academy of Sciences of the United States of America 2010
Human Monoclonal IL27 Primary Antibody for FACS - ABIN4900122
Seyerl, Kirchberger, Majdic, Seipelt, Jindra, Schrauf, Stöckl: Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. in European journal of immunology 2010
Human Polyclonal IL27 Primary Antibody for EIA, IF - ABIN500000
Hunter: New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. in Nature reviews. Immunology 2005
These results identify IL-27 and its specific receptor IL27RA (show IL27RA Antibodies) as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.
serum IL-27 levels were significantly higher in stage III EV71-infected hand, foot, and mouth disease patients with early cardiopulmonary failure and strong correlation with CRP (show CRP Antibodies) levels; IL27p28 polymorphisms (rs153109, rs17855750, and rs181206) did not influence IL-27 production, and these three SNPs were not associated with EV71 infection risk and clinical stage
these results suggest that IL-27 might predominantly play a protective role in the pathogenesis of psoriasis through abrogating Th17 differentiation.
our data suggest a previously unrecognized role for IL-27 in regulating epithelial cell proliferation and antiviral host defense during the normal wound healing response.
An association between the IL-27 single nucleotide polymorphism (SNP) rs153109 and Atrial Fibrillation was found in Chinese Han population. The G allele and GG genotype of rs153109 were associated with increased AF risk (odds ratio [OR]: 1.35, 95% confidence intervals [CI]=1.06-1.71, p=0.02 and OR: 1.66, 95% CI=1.03-2.65, p=0.03 in the recessive genetic model, respectively)
Study demonstrated that levels of circulating serum IL-27 were elevated in rheumatoid arthritis (RA) patients and were positively correlated with RA disease activity. Moreover, these concentrations decreased after effective immunosuppressant treatment suggesting its involvement in the pathogenesis of RA.
Data indicate that the genetic variant rs153109 in the 5' upstream region of interleukin 27 (IL-27) is significantly associated with ulcerative colitis (UC) in Chinese Han individuals.
this study shows that the serum levels of IL-27 are lower in Iranian diabetes type I patients compared to the healthy individuals
our findings showed a relationship between the IL-27 2905T/G genotype variant and the decreased susceptibility for developing cervical cancer. The IL-27 2905T/G genotype variant also modified the survival time in cervical cancer patients.
an IL-27/Stat3 (show STAT3 Antibodies) axis induces expression of programmed cell death 1 (show PDCD1 Antibodies) ligands (PD-L1 (show CD274 Antibodies)/2) on infiltrating macrophages in lymphoma
this study shows that IL-27 plays an important role in immune response and pathogen clearance during infection with Candida parapsilosis
Inhibition of IL-27p28 also enhanced the suppressive capacity of adoptively transferred CD4 (show CD4 Antibodies)(+) nTregs by increasing the stability of Foxp3 (show FOXP3 Antibodies) expression.
These data provide evidence of a central role of IL-27 for the control of Th2-mediated allergic diseases.
These data indicate that endogenous IL-27 limits pathology during parainfluenza virus infection
recombinant IL-30 showed its biological activity by inhibiting Th17 differentiating from naive CD4 (show CD4 Antibodies)(+) T cells. Therefore, this method of express and purifying IL-30 provides novel procedures to facilitate structural and functions studies of IL-30.
An IL-27/Lag3 (show LAG3 Antibodies) axis enhances Foxp3 (show FOXP3 Antibodies)+ regulatory T cell-suppressive function and therapeutic efficacy.
IL-27 is one of the limited unique cytokines directly acting on hematopoietic stem cells (HSCs) to promote differentiation into myeloid progenitors during emergency myelopoiesis.
These results provide the first evidences that Fli-1 (show FLI1 Antibodies) positively regulates LPS (show TLR4 Antibodies)-induced IL-27 production in macrophages
of autocrine/paracrine mechanisms involving IL-27 in adipocytes under conditions of inflammatory stress that may link obesity with inflammatory diseases.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
, IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interleukin 27 p28 subunit
, interluekin 27