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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Additionally we are shipping IL27 Kits (48) and IL27 Proteins (27) and many more products for this protein.
Showing 10 out of 165 products:
Mouse (Murine) Monoclonal IL27 Primary Antibody for ICS, Neut - ABIN2689756
Hall, Silver, Hunter: The immunobiology of IL-27. in Advances in immunology 2012
Show all 7 Pubmed References
Mouse (Murine) Monoclonal IL27 Primary Antibody for WB - ABIN1043836
Murugaiyan, Mittal, Weiner: Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. in Proceedings of the National Academy of Sciences of the United States of America 2010
Mouse (Murine) Polyclonal IL27 Primary Antibody for WB - ABIN1043831
Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. in Immunity 2002
Human Monoclonal IL27 Primary Antibody for CyTOF, FACS - ABIN4900122
Seyerl, Kirchberger, Majdic, Seipelt, Jindra, Schrauf, Stöckl: Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. in European journal of immunology 2010
IL-27 stimulation activated STAT1 (show STAT1 Antibodies) and STAT3 (show STAT3 Antibodies) in HeLa and T98G cells, suggesting that IL-27 engages the STAT1 (show STAT1 Antibodies)/3 pathway, which then leads to the upregulation of IL-6 (show IL6 Antibodies), IP-10 (show CXCL10 Antibodies), and MIG (show CXCL9 Antibodies)
IL-27 and IL-37 limit the induction of particular T cell subsets along with cytokine responses in S. stercoralis infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helminth infection.
IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th17 cells to produce IL-10 (show IL10 Antibodies).
HIV and Tat (show TAT Antibodies) inhibit LPS (show IRF6 Antibodies)-induced IL-27 production in human macrophages via distinct mechanisms: Tat (show TAT Antibodies) through the inhibition of cIAP-1 (show BIRC2 Antibodies)-TRAF-6 (show TRAF6 Antibodies) and subsequent inhibition of PI3K (show PIK3CA Antibodies) and p38 (show CRK Antibodies) MAPKs, whereas HIV through the inhibition of p38 MAPK (show MAPK14 Antibodies) activation.
IL27 (show EBI3 Antibodies) recapitulates IFN-gamma (show IFNG Antibodies) responses in hepatocellular carcinoma cells, but is inhibited by IL6 (show IL6 Antibodies)-type cytokines.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (show IL1B Antibodies) secretion levels triggered by dual LPS (show IRF6 Antibodies)-ATP stimulation.
IL-27 enhanced the cytotoxicity and suppressed the proliferation of ovarian cancer cells
Study of the expression of IL-17 (show IL17A Antibodies) provides theoretical support for the clinical treatment and prognosis prediction of ovarian epithelial tumor.
the sIL (show PMEL Antibodies)-6R/p28 (show PSMD10 Antibodies) fusion protein (FP) upregulated IFN-lambda1 expression by increasing the binding abilities of c-Fos and activating transcription factor 1 (show AFT1 Antibodies) to the IFN-lambda1 promoter via the p38 MAPK (show MAPK14 Antibodies) signaling pathway; results demonstrate the important role of sIL (show PMEL Antibodies)-6R/p28 (show PSMD10 Antibodies) FP in mediating virus-induced type III IFN production.
These results identify IL-27 and its specific receptor IL27RA (show IL27RA Antibodies) as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.
We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.
These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.
results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (show IL1B Antibodies) secretion levels triggered by dual LPS (show TLR4 Antibodies)-ATP stimulation.
findings show that PGE2 inhibits IL-27 production in macrophages and in splenic conventional dendritic cells; and identify a novel pathway consisting of signaling through EP2/EP4-->induction of cAMP-->downregulation of IFN regulatory factor 1 expression and binding to the p28 IFN-stimulated response element site
these data provide the first evidence that IL-27 signals directly to B (show TDO2 Antibodies) cells promote GCs (show UGCG Antibodies) and support the role of IL-27 in lupus.
this study shows that IL-27 plays an important role in immune response and pathogen clearance during infection with Candida parapsilosis
Inhibition of IL-27p28 also enhanced the suppressive capacity of adoptively transferred CD4 (show CD4 Antibodies)(+) nTregs by increasing the stability of Foxp3 (show FOXP3 Antibodies) expression.
These data provide evidence of a central role of IL-27 for the control of Th2-mediated allergic diseases.
These data indicate that endogenous IL-27 limits pathology during parainfluenza virus infection
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
, IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interleukin 27 p28 subunit
, interluekin 27