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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. Additionally we are shipping IL27 Antibodies (148) and IL27 Kits (48) and many more products for this protein.
Showing 10 out of 27 products:
Human IL27 Protein expressed in CHO Cells - ABIN2002020
Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. in Immunity 2002
Show all 5 references for ABIN2002020
Mouse (Murine) IL27 Protein expressed in Human Cells - ABIN2008620
Fakruddin, Lempicki, Gorelick, Yang, Adelsberger, Garcia-Pineres, Pinto, Lane, Imamichi: Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27. in Blood 2007
Show all 5 references for ABIN2008620
Human IL27 Protein expressed in Wheat germ - ABIN1307800
Di Meo, Airoldi, Sorrentino, Zorzoli, Esposito, Di Carlo: Interleukin-30 expression in prostate cancer and its draining lymph nodes correlates with advanced grade and stage. in Clinical cancer research : an official journal of the American Association for Cancer Research 2014
Show all 2 references for ABIN1307800
our data suggest a previously unrecognized role for IL-27 in regulating epithelial cell proliferation and antiviral host defense during the normal wound healing response.
An association between the IL-27 single nucleotide polymorphism (SNP) rs153109 and Atrial Fibrillation was found in Chinese Han population. The G allele and GG genotype of rs153109 were associated with increased AF risk (odds ratio [OR]: 1.35, 95% confidence intervals [CI]=1.06-1.71, p=0.02 and OR: 1.66, 95% CI=1.03-2.65, p=0.03 in the recessive genetic model, respectively)
Study demonstrated that levels of circulating serum IL-27 were elevated in rheumatoid arthritis (RA) patients and were positively correlated with RA disease activity. Moreover, these concentrations decreased after effective immunosuppressant treatment suggesting its involvement in the pathogenesis of RA.
Data indicate that the genetic variant rs153109 in the 5' upstream region of interleukin 27 (IL-27) is significantly associated with ulcerative colitis (UC) in Chinese Han individuals.
this study shows that the serum levels of IL-27 are lower in Iranian diabetes type I patients compared to the healthy individuals
our findings showed a relationship between the IL-27 2905T/G genotype variant and the decreased susceptibility for developing cervical cancer. The IL-27 2905T/G genotype variant also modified the survival time in cervical cancer patients.
an IL-27/Stat3 (show STAT3 Proteins) axis induces expression of programmed cell death 1 (show PDCD1 Proteins) ligands (PD-L1 (show CD274 Proteins)/2) on infiltrating macrophages in lymphoma
Interleukin-27 rs 153109 Single Nucleotide Polymorphism is associated with responses to therapy in Hepatitis C.
this study shows that IL-27 gene polymorphism is genetic risk factor for systemic lupus erythematosus in the Polish population, and that it predicts disease phenotype
Data indicate that the CC genotype of interleukin 27 (IL-27) single nucleotide polymorphism rs153109 was significantly more prevalent in pre-eclampsia (PE) cases than controls.
recombinant IL-30 showed its biological activity by inhibiting Th17 differentiating from naive CD4 (show CD4 Proteins)(+) T cells. Therefore, this method of express and purifying IL-30 provides novel procedures to facilitate structural and functions studies of IL-30.
An IL-27/Lag3 (show LAG3 Proteins) axis enhances Foxp3 (show FOXP3 Proteins)+ regulatory T cell-suppressive function and therapeutic efficacy.
IL-27 is one of the limited unique cytokines directly acting on hematopoietic stem cells (HSCs) to promote differentiation into myeloid progenitors during emergency myelopoiesis.
These results provide the first evidences that Fli-1 (show FLI1 Proteins) positively regulates LPS (show TLR4 Proteins)-induced IL-27 production in macrophages
of autocrine/paracrine mechanisms involving IL-27 in adipocytes under conditions of inflammatory stress that may link obesity with inflammatory diseases.
Increased IL-27 expression in bleomycin-induced pulmonary fibrosis was noted.
IL-27 induces the endothelial differentiation in cardiac resident stem cells through STAT3 (show STAT3 Proteins)/Pim-1 (show PIM1 Proteins) signaling pathway.
demonstrate that suppression mediated by interferon (show IFNA Proteins) and IL-27 is a negative feedback mechanism for group 2 innate lymphoid cells function in vivo
Natural killer cells-dendritic cells interaction elicits a positive feedback loop for IFN-gamma (show IFNG Proteins) and IL-27 production.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
, IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interleukin 27 p28 subunit
, interluekin 27