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IL28B encodes a cytokine distantly related to type I interferons and the IL-10 family. Additionally we are shipping Interleukin 28B (Interferon, lambda 3) Kits (16) and Interleukin 28B (Interferon, lambda 3) Proteins (9) and many more products for this protein.
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Human Polyclonal IL28B Primary Antibody for EIA, WB - ABIN952885
Lindh, Lagging, Norkrans, Hellstrand: Observed and calculated interleukin-28B genotype frequencies in hepatitis C virus infection. in Hepatology (Baltimore, Md.) 2010
Show all 4 references for ABIN952885
IL-28B down-regulates Tregs following subunit vaccine ESAT6-Ag85B-Mpt64(190-198)-Mtb8.4-HspX (show HSP Antibodies) vaccination but does not improve the protective immune responses.
the role of IFN-lambda in IDO (show IDO1 Antibodies) regulation was investigated after influenza infection of respiratory epithelial cells.
Data indicate that rotavirus infection induces production of interferon (show IFNA Antibodies)-lambda (IFN-lambda) and interleukin 22 (IL-22 (show IL22 Antibodies)) by intestinal epithelial cells.
Acritical role of IL-28 cytokines is in controlling T cell responses in vivo through the modulation of lung CD11c (show ITGAX Antibodies)(+) DC function in experimental allergic asthma.
IFN-alpha (show IFNA Antibodies), IFN-beta (show IFNB1 Antibodies), and IFN-gamma (show IFNG Antibodies) were observed in the anterior segment of injected eyes through 72 hours and mRNA levels of IFN-beta (show IFNB1 Antibodies) and IFN-gamma (show IFNG Antibodies) were increased in virus-infected eyes 48 to 120 hours after herpes simplex infection
the duration of IFNlambda signaling to JAK (show JAK3 Antibodies)/STAT (show STAT1 Antibodies) is different from that of IFNalpha
intranasal influenza A virus infection leads to the robust type III IFN induction in the lungs of both WT and IFNAR (show IFNAR1 Antibodies)-/- mice
IL-28A (show IL28A Antibodies) emerges as a key regulatory cytokine with pathogenic function in T-cell-mediated liver injury
Type III interferon (show IFNA Antibodies)/IL-28 targets a specific subset of cells and contributes to the antiviral response evoked by Toll (show TLR4 Antibodies)-like receptors, largely mediated by inducing an antiviral state in epithelial cells.
IL-28B can induce 100% protection from mortality after a lethal influenza challenge
The IL13 (show IL13 Antibodies) rs20541 T allele and IL28B rs8099917 GG genotype are negative predictors of survival in patients on renal replacement therapy, while the IL28B rs12979860 TT genotype increases the risk of death only in patients negative for HBV or HCV infection.
In this study, there was association of the three isolated polymorphisms (rs8099917, rs12979860 and rs368234815) with both clinical outcome and response to treatment with PEG (show PAEP Antibodies)-IFN and RBV in chronic hepatitis C.
The frequency of colonic Treg cells in hepatitis C virus-infected patients had a strong association with the IL-28B genotype and may have a significant impact on hepatitis C virus clearance.
In treatment-naive chronic hepatitis C patients treated with pegylated interferon (show IFNA Antibodies) and ribavirin, a polymorphism upstream CC at the site rs12979860 of IL-28B is associated with increased sustained virologic response and effectively predicts treatment outcome.
findings support a model in which IFNL3 mRNA translation efficiency, governed by allele-specific mRNA structures, modulates clearance of hepatitis C virus infection
SNP rs4803217, located in the 3' untranslated region (UTR (show UTS2R Antibodies)) of IFNL3, has also been proposed as a causal variant for HCV clearance
IFNL3 genotype is associated with differential induction of IFNL3 in primary human hepatocytes
study conducted to determine the association of IL-28B rs12980275, rs12979860, and rs8099917 gene polymorphism(s) with the response (including relapse) following dual pegIFN and ribavirin therapy in genotype 4 hepatitis C Egyptian patients; SNPs at IL-28/60 and IL-28/75 are possible predictors of relapse in patients receiving dual treatment
Steatosis severity was independently associated with IL28B rs12979860 in large cohort of patients with genotype 1 Chronic hepatitis C.
Vitamin D related (VDR (show CYP27B1 Antibodies) rs2228570 and CYP2R1 (show CYP2R1 Antibodies) rs10741657) and IL28B rs12979860 genes polymorphisms accurately assure sustained viral response in naive CHC (show CLTC Antibodies) G4 patients treated with low cost standard therapy.
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA).
, interferon alpha
, interferon lambda-3
, interleukin 28
, cytokine Zcyto22
, interferon lambda-4
, interferon, lambda 4
, interleukin 28B (interferon, lambda 3)
, interleukin 28C