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IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. Additionally we are shipping Interleukin 31 Antibodies (116) and Interleukin 31 Kits (50) and many more products for this protein.
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While serum TSLP (show TSLP Proteins) levels were unaffected by concomitant allergies and atopic comorbidities, serum levels of IL-31, IL-33 (show IL33 Proteins) and sST2 (show SSTR2 Proteins) were affected to a small extent. We found a positive correlation between TSLP (show TSLP Proteins), IL-31 and IL-33 (show IL33 Proteins), and an inverse relationship between IL-33 (show IL33 Proteins) and sST2 (show SSTR2 Proteins)
Suggest that IL-31 gene may play a role in the development of systemic lupus erythematosus.
High IL31 expression is associated with Endometrial Cancer.
In a CML (show BCR Proteins) patient with pruritus receiving imatinib mesylate, IL-31 and IL-33 (show IL33 Proteins) serum levels were significantly higher than controls. Imatinib could cause keratinocyte injury, the release of IL-33 (show IL33 Proteins), and the consequent interaction with its receptor on mast cells, inducing IL-31 secretion. The IL-31/IL-33 (show IL33 Proteins) axis may be involved in the pathogenesis of skin side effects related to imatinib mesylate treatment.
Distinct polymorphic variants of the IL-31 gene may be involved in the patho-genesis of mastocytosis, and IL-31 may be involved in the induction of pruritus in patients with mastocytosis.
Serum/pleural fluid IL-31 levels are elevated in tuberculous pleural effusion.
both SCF (show KITLG Proteins) and IL-31 play an important role in mediating inflammation and enhancing severity of atopic asthma.
IL-31 affects keratinocyte differentiation in multiple ways and the IL-1 (show IL1A Proteins) cytokine network is a major downstream effector of IL-31 signaling in deregulating the physical skin barrier.
Oncostatin M (show OSM Proteins) and interleukin-31: Cytokines, receptors, signal transduction and physiology.
The results of our analyses regarding serum levels and receptor expression do not suggest a central role of IL-31 in Mycosis fungoides/Sezary syndrome pathogenesis.
IL-31 upregulates IL-31RA (show IL31RA Proteins) expression in DRG neuron cell bodies, and cutaneous-injected IL-31-induced itching is enhanced by DRG IL-31RA (show IL31RA Proteins) expression in mice
our results suggest a functional cooperation between NFAT1 (show NFAT1 Proteins) and JunB (show JUNB Proteins) in mediating IL-31 gene expression in CD4 (show CD4 Proteins)(+) T cells
Data not only illustrate various functions that cysteines perform during IL-31 biosynthesis and secretion, but also highlight their potential roles in cytokine effector functions.
IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases
IL-31 interaction with IL-31 receptor (IL-31R) is identified in an acute model of T helper cell type 2 inflammation in the lung.
these data provide the first evidence of a function for IL-31-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine.
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004