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Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. Additionally we are shipping ICK Kits (8) and ICK Proteins (6) and many more products for this protein.
Showing 10 out of 72 products:
Human Polyclonal ICK Primary Antibody for IF, IHC - ABIN1534198
Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: The DNA sequence and analysis of human chromosome 6. ... in Nature 2003
Human Polyclonal ICK Primary Antibody for ELISA, WB - ABIN564945
Vallesi, Di Pretoro, Ballarini, Apone, Luporini et al.: A novel protein kinase from the ciliate Euplotes raikovi with close structural identity to the mammalian intestinal and male-germ cell kinases: characterization and functional implications in the ... in Protist 2010
findings suggest that increased ICK expression/activity in response to protein deprivation likely provides a novel protective mechanism to limit apoptosis and support compensatory mucosal growth under nutritional stress.
the expressions of ICK/MAK (show MAK Antibodies)/MOK (show MOK Antibodies) proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases.
In glioblastoma cells with deregulated high levels of CCRK (show CDK20 Antibodies), its depletion restores cilia through ICK and an ICK-related kinase MAK (show MAK Antibodies), thereby inhibiting glioblastoma cell proliferation.
High ICK expression is associated with prostate cancer.
an important role for ICK in modulating the activity of mTORC1 through phosphorylation of Raptor (show RPTOR Antibodies) Thr (show TRH Antibodies)-908.
ICK may play a role in the development of multiple organ systems. R272Q has been associated with endocrine-cerebro-osteodysplasia and may explain loss of function since the R272Q mutant fails to localize at the nucleus and has diminished kinase activity
ICK plays an important role in the regulation of proliferation and differentiation of intestinal epithelial cells. ICK may control G1 cell cycle progression by regulating expression of cell cycle regulators cyclin D1 (show CCND1 Antibodies), c-Myc (show MYC Antibodies) and p21Cip1 (show CDKN1A Antibodies).
ICK and FBX9 (show FBXO9 Antibodies) are divergently transcribed from a bidirectional promoter that is GC-rich (show RELB Antibodies) and contains a CpG island.
PP5 (protein phosphatase 5)and CCRK (cell cycle-related kinase (show CDK20 Antibodies)) are yin-yang regulators of T157 phosphorylation. ICK interacts with and phosphorylates human Scythe (show BAT3 Antibodies), an essential regulator of proliferation and apoptosis during mammalian development.
ICK is the prototype for a new group of MAPK (show MAPK1 Antibodies)-like kinases requiring dual phosphorylation at TDY (show SRY Antibodies) motifs.
the expressions of ICK/MAK (show MAK Antibodies)/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases.
Data indicate that ciliary defects caused by a lack of functional intestinal cell kinase (ICK) leads to abnormal Sonic hedgehog (Shh (show SHH Antibodies)) signaling, resulting in congenital disorders such as endocrine-cerebro-osteodysplasia (ECO) syndrome .
ICK is a Kif3a (show KIF3A Antibodies) kinase and essential for proper ciliogenesis in development by regulating ciliary transport at the tip of cilia.
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.
intestinal cell (MAK-like) kinase
, intestinal cell kinase
, serine/threonine-protein kinase ICK-like
, MAK-related kinase
, laryngeal cancer kinase 2
, serine/threonine protein kinase
, serine/threonine-protein kinase ICK
, heart serine-threonine protein kinase