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Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. Additionally we are shipping ICK Antibodies (72) and ICK Kits (8) and many more products for this protein.
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findings suggest that increased ICK expression/activity in response to protein deprivation likely provides a novel protective mechanism to limit apoptosis and support compensatory mucosal growth under nutritional stress.
the expressions of ICK/MAK (show MAK Proteins)/MOK (show MOK Proteins) proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases.
In glioblastoma cells with deregulated high levels of CCRK (show CDK20 Proteins), its depletion restores cilia through ICK and an ICK-related kinase MAK (show MAK Proteins), thereby inhibiting glioblastoma cell proliferation.
High ICK expression is associated with prostate cancer.
an important role for ICK in modulating the activity of mTORC1 through phosphorylation of Raptor (show RPTOR Proteins) Thr (show TRH Proteins)-908.
ICK may play a role in the development of multiple organ systems. R272Q has been associated with endocrine-cerebro-osteodysplasia and may explain loss of function since the R272Q mutant fails to localize at the nucleus and has diminished kinase activity
ICK plays an important role in the regulation of proliferation and differentiation of intestinal epithelial cells. ICK may control G1 cell cycle progression by regulating expression of cell cycle regulators cyclin D1 (show CCND1 Proteins), c-Myc (show MYC Proteins) and p21Cip1 (show CDKN1A Proteins).
ICK and FBX9 (show FBXO9 Proteins) are divergently transcribed from a bidirectional promoter that is GC-rich (show RELB Proteins) and contains a CpG island.
PP5 (protein phosphatase 5)and CCRK (cell cycle-related kinase (show CDK20 Proteins)) are yin-yang regulators of T157 phosphorylation. ICK interacts with and phosphorylates human Scythe (show BAT3 Proteins), an essential regulator of proliferation and apoptosis during mammalian development.
ICK is the prototype for a new group of MAPK (show MAPK1 Proteins)-like kinases requiring dual phosphorylation at TDY (show SRY Proteins) motifs.
the expressions of ICK/MAK (show MAK Proteins)/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases.
Data indicate that ciliary defects caused by a lack of functional intestinal cell kinase (ICK) leads to abnormal Sonic hedgehog (Shh (show SHH Proteins)) signaling, resulting in congenital disorders such as endocrine-cerebro-osteodysplasia (ECO) syndrome .
ICK is a Kif3a (show KIF3A Proteins) kinase and essential for proper ciliogenesis in development by regulating ciliary transport at the tip of cilia.
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.
intestinal cell (MAK-like) kinase
, intestinal cell kinase
, serine/threonine-protein kinase ICK-like
, MAK-related kinase
, laryngeal cancer kinase 2
, serine/threonine protein kinase
, serine/threonine-protein kinase ICK
, heart serine-threonine protein kinase