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Iodotyrosine Deiodinase Proteins (IYD)

IYD encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. Additionally we are shipping Iodotyrosine Deiodinase Antibodies (13) and Iodotyrosine Deiodinase Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IYD 389434 Q6PHW0
IYD 70337 Q9DCX8
IYD 308129 Q5BK17
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Top Iodotyrosine Deiodinase Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,445.67
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,458.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$388.93
Details

IYD Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Iodotyrosine Deiodinase (IYD) Interaction Partners

Xenopus laevis Iodotyrosine Deiodinase (IYD) interaction partners

  1. findings suggest that IYD transcription is activated by TH receptors early during intestinal remodeling to ensure efficient iodine recycling at the climax of metamorphosis when high levels of TH are needed for proper transformations of different organs.

Human Iodotyrosine Deiodinase (IYD) interaction partners

  1. The rate-limiting processes that contribute to the ability of flavin to promote reductive dehalogenation in human IYD.

  2. A switch between one- and two-electron chemistry of iodotyrosine deiodinase is controlled by substrate.

  3. Iodotyrosine deiodinase defect identified via genome-wide approach.

  4. high activity of human saliva (show RAG1AP1 Proteins) peroxidase with iodide as a substrate may play a crucial role in the bioavailability and metabolism of biologically active iodide.

  5. Mutations in DEHAL1 leads to hypothyroidism, goiter and mental retardation (Review)

  6. molecular cloning and investigation of the localization and activity of DEHAL1

  7. the cytoplasmic tail of DEHAL1 could play a role in the stability of the protein

  8. Diffuse cytoplasmatic localisation or downregulation of DEHAL1 expression in thyroid cancers suggests alteration or loss of DEHAL1 function during thyroid cell dedifferentiation.

  9. homozygous mutations in DEHAL1 appear to cause human iodotyrosine deiodinase deficiency, leading to hereditary hypothyroidism and goiter

  10. This study describes a functional mutation within IYD, demonstrating the molecular basis of the iodine wasting form of congenital hypothyroidism

Mouse (Murine) Iodotyrosine Deiodinase (IYD) interaction partners

  1. At least for Metazoa, IYD should provide a new marker for tracing the evolutionary development of iodinated amino acids as regulatory signals through the tree of life.

  2. Data show that the structures provide a molecular basis for understanding thyroid disease based on mutations of IYD.

Iodotyrosine Deiodinase (IYD) Protein Profile

Protein Summary

This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Iodotyrosine Deiodinase Proteins (IYD)

  • iodotyrosine deiodinase (IYD)
  • iodotyrosine deiodinase (iyd)
  • iodotyrosine deiodinase (Iyd)
  • 0610009A07Rik protein
  • AI265638 protein
  • C6orf71 protein
  • Dehal1 protein
  • dJ422F24.1 protein
  • IYD-1 protein
  • MGC85450 protein
  • RGD1309288 protein
  • TDH4 protein

Protein level used designations for Iodotyrosine Deiodinase Proteins (IYD)

iodotyrosine deiodinase , iodotyrosine dehalogenase 1 , IYD-1 , iodotyrosine dehalogenase 1 protein

GENE ID SPECIES
421631 Gallus gallus
447152 Xenopus laevis
472159 Pan troglodytes
476244 Canis lupus familiaris
496718 Xenopus (Silurana) tropicalis
534110 Bos taurus
705471 Macaca mulatta
389434 Homo sapiens
70337 Mus musculus
308129 Rattus norvegicus
403124 Sus scrofa
100127058 Pongo abelii
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