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Iron-Responsive Element Binding Protein 2 Proteins (IREB2)

RNA-binding proteins that bind iron-responsive elements (IREs) [RGD, Feb 2006].. Additionally we are shipping IREB2 Antibodies (76) and IREB2 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IREB2 64602 Q811J3
Rat IREB2 IREB2 64831 Q62751
IREB2 3658 P48200
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Top IREB2 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 39 to 44 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

IREB2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,

More Proteins for Iron-Responsive Element Binding Protein 2 (IREB2) Interaction Partners

Mouse (Murine) Iron-Responsive Element Binding Protein 2 (IREB2) interaction partners

  1. The Irp2(-/-) mice develop microcytic anemia, erythropoietic protoporphyria (show FECH Proteins) and a progressive neurological disorder, indicating that Irp2 has important functions in the nervous system and erythropoietic homeostasis

  2. Irp2 mRNA transcription is promoted by circadian clock genes, including BMAL1 (show ARNTL Proteins), and the CLOCK heterodimer.

  3. Irp2 increased mitochondrial iron loading and levels of cytochrome c oxidase, which led to mitochondrial dysfunction and subsequent experimental COPD.

  4. IRP1 (show ACO1 Proteins) and IRP2 mutant mice rapidly succumb to systemic infection with Salmonella Typhimurium, a pathogenic bacterium that multiplies within macrophages, with increased bacterial burdens in liver and spleen.

  5. aged Irp2-/- mice show marked iron deposition in white matter and in oligodendrocytes while iron content is significantly reduced in neurons. mice show impairments in locomotion, exploration, motor coordination/balance and nociception .

  6. misregulation of iron metabolism from loss of Irp2 causes lower motor neuronal degeneration with significant spinal cord axonopathy

  7. A wide network of mRNAs and proteins with iron-dependent regulation, IRP (show WNT2 Proteins)-dependent regulation, or both.

  8. The FBXL5 (show FBXL5 Proteins)-IRP2 axis is integral to control of iron metabolism in vivo.

  9. Iron regulatory protein 1 (show ACO1 Proteins) outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.

  10. Mice lacking both IRP2 in their hepatocytes suffer from mitochondrial iron deficiency and dysfunction associated with alterations of the ISC and heme biosynthetic pathways, leading to liver failure and death.

Human Iron-Responsive Element Binding Protein 2 (IREB2) interaction partners

  1. This study confirms that the IREB2 variants contribute to an increased risk of lung cancer, whereas FAM13A predisposes to increased susceptibility to chronic obstructive pulmonary disease.

  2. IREB2 - candidate gene for Chronic Obstructive Pulmonary Disease identified by Genome-wide association studies.

  3. Irp2 expression is increased in airway epithelial cells exposed to cigarette smoke.

  4. IRP2 can regulate the expression of TfR (show TFRC Proteins) and Fn by changing its own protein expression and thereby regulate iron metabolism.

  5. Genetic variants near IREB2 and GALC (show GALC Proteins) likely contribute to genetic susceptibility to PAE associated with COPD (show ARCN1 Proteins).

  6. Haplotypes of IREB2 carrying major alleles of rs2568494 (G), rs2656069 (A), rs10851906 (A), rs965604 (C) and minor alleles of rs1964678 (T), rs12593229 (T) showed negative correlation with lung function amongst South Indian male smokers with COPD (show ARCN1 Proteins).

  7. Ascorbate-induced up-regulation of cellular ferroportin (show SLC40A1 Proteins) levels was associated with increased levels of the iron regulatory protein IRP2, and the hypoxia-inducible factor HIF2alpha (show EPAS1 Proteins).

  8. dysregulation of IRP2 is an early nodal point underlying altered iron metabolism in breast cancer and may contribute to poor outcome of some patients with breast cancer

  9. IREB2 polymorphisms were associated with chronic obstructive pulmonary disease in non-smoking Chinese Han subjects

  10. A replication of association between two SNPs previously associated with COPD (show ARCN1 Proteins) (CHRNA3 (show CHRNA3 Proteins)/5 and IREB2), as well as an association with COPD (show ARCN1 Proteins) of one locus initially associated with lung function (ADCY2 (show ADCY2 Proteins)).

IREB2 Protein Profile

Protein Summary

RNA-binding proteins that bind iron-responsive elements (IREs)

Gene names and symbols associated with IREB2

  • iron-responsive element binding protein 2 (IREB2)
  • iron-responsive element binding protein 2 (ireb2)
  • iron-responsive element binding protein 2 (LOC100341900)
  • iron responsive element binding protein 2 (Ireb2)
  • ACO3 protein
  • D9Ertd85e protein
  • DKFZp468N047 protein
  • im:7153062 protein
  • IREB2 protein
  • IREBP2 protein
  • IRP2 protein
  • IRP2AD protein

Protein level used designations for IREB2

iron-responsive element binding protein 2 , IRP2 , iron regulatory protein 2 , Iron-responsive element-binding protein 2 , iron-responsive element-binding protein 2-like , IRE-BP 2 , iron-responsive element-binding protein 2 , iron-regulatory protein 2

467731 Pan troglodytes
539404 Bos taurus
652982 Danio rerio
100012608 Monodelphis domestica
100050493 Equus caballus
100082579 Ornithorhynchus anatinus
100174315 Pongo abelii
100341900 Oryctolagus cuniculus
100380628 Salmo salar
100385776 Callithrix jacchus
100580664 Nomascus leucogenys
64602 Mus musculus
64831 Rattus norvegicus
3658 Homo sapiens
414584 Xenopus laevis
475134 Canis lupus familiaris
100153993 Sus scrofa
427490 Gallus gallus
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