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ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004 [PubMed 15262227]).[supplied by OMIM, Mar 2008].. Additionally we are shipping ISCA1 Antibodies (19) and many more products for this protein.
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The structural plasticity of the dimeric state of the [2Fe-2S] bound form of human GRX5 (show GLRX5 Proteins) is the crucial factor that allows an efficient cluster transfer to the partner proteins human ISCA1 and ISCA2 (show ISCA2 Proteins) by a specific protein-protein recognition mechanism.
The data presented here show that the Isu1 suppressor mimics the frataxin (show FXN Proteins) effects on Nfs1 (show NFS1 Proteins), explaining the bypassing activity.
ISCA1, ISCA2 (show ISCA2 Proteins), and IBA57 (show IBA57 Proteins) were depleted by RNA interference. Depleted cells contained massively swollen and enlarged mitochondria that were virtually devoid of cristae membranes, demonstrating the importance of these proteins for mitochondrial biogenesis.
screening a human brain cDNA expression library with serum from a patient suffering from the autoimmune Sjogren's syndrome yielded a gene product called hIscA implicated in iron-sulfur cluster biogenesis
human IscA1 plays an important role in both mitochondrial and cytosolic iron-sulfur cluster biogenesis, and a notable component of the latter is the interaction between IscA1 and IOP1 (show NARFL Proteins).
Data suggest that miR (show MLXIP Proteins)-210 induced repression of ISCU1/2 may contribute to HIF-1alpha (show HIF1A Proteins)-triggered alterations in neuronal energy metabolism after nickel exposure.
ISCA1 is a mitochondrial protein involved in the biogenesis and assembly of iron-sulfur clusters, which play a role in electron-transfer reactions (Cozar-Castellano et al., 2004
HESB like domain containing 2
, HESB-like domain-containing protein 2
, iron sulfur assembly protein IscA
, iron-sulfur assembly protein IscA
, iron-sulfur cluster assembly 1 homolog, mitochondrial
, HesB protein