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Iron-Sulfur Cluster Scaffold Homolog (E. Coli) Proteins (ISCU)

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. Additionally we are shipping ISCU Antibodies (58) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ISCU 23479 Q9H1K1
Rat ISCU ISCU 288740  
ISCU 66383 Q9D7P6
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Top ISCU Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Shigella flexneri His tag   1 mg Log in to see 56 to 66 Days
$2,262.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 3 to 4 Days
$364.64
Details
HOST_Escherichia coli (E. coli) Human His tag   1 μg Log in to see 6 to 11 Days
$142.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ISCU Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Top referenced ISCU Proteins

  1. Human ISCU Protein expressed in Escherichia coli (E. coli) - ABIN667303 : Tong, Rouault: Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis. in Cell metabolism 2006 (PubMed)
    Show all 2 references for ABIN667303

More Proteins for Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) Interaction Partners

Human Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (show TP53 Proteins) mutation.

  2. Thus, driven by acquired (hypoxia) or genetic causes, the miR (show MLXIP Proteins)-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing iron-sulfur deficiency and pulmonary hypertension.

  3. The core Fe-S biosynthetic enzymatic complex generated [2Fe-2S] cluster intermediates that converted to stable [2Fe-2S] clusters bound to uncomplexed ISCU2.

  4. IscU is a new substrate of MK2 (show KCNA2 Proteins) both in Drosophila cells and in human cells

  5. Fe-S assembly protein (ISCU2) and frataxin (show FXN Proteins) convert substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.

  6. the G50E iron-sulfur cluster scaffold protein (show NFU1 Proteins) (ISCU) mutation has a role in mitochondrial myopathy

  7. NFS1 (show NFS1 Proteins) binds preferentially to the D-state of ISCU while mtHSP70 (show HSPA9 Proteins) binds preferentially to the D-state of ISCU and HSC20 (show HSCB Proteins) binds preferentially to the S-state of ISCU.

  8. mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.

  9. MicroRNA-210 correlates negatively with its gene target ISCU at the protein and mRNA level. MicroRNA-210 correlated with positive outcome variables

  10. ISCU protein deficiency in patients results from muscle-specific (show EIF3K Proteins) mis (show AMH Proteins)-splicing and oxidative stress.

Mouse (Murine) Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (show TP53 Proteins) mutation.

  2. IscU is a marginally stable protein at low ionic strength to the point that undergoes cold denaturation at around -8 degrees C with a corresponding dramatic decrease of enthalpy, which is consistent with the fluxional nature of the protein.

  3. mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.

  4. Data show that complete loss of ISCU results in early embryonic death and confirm a fundamental role for ISCU in mammals.

  5. While IFN-gamma (show IFNG Proteins) alone induced Nfs1 (show NFS1 Proteins) protein instability, LPS (show TLR4 Proteins) triggered a delayed decline of Nfs1 (show NFS1 Proteins), rather involving transcriptional events or mRNA instability.

ISCU Protein Profile

Protein Summary

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

Gene names and symbols associated with ISCU

  • iron-sulfur cluster assembly enzyme ISCU, mitochondrial (Iscu)
  • iron-sulfur cluster scaffold homolog (E. coli) (ISCU)
  • IscU iron-sulfur cluster scaffold homolog (E. coli) (iscu)
  • iron-sulfur cluster assembly enzyme (ISCU)
  • iron-sulfur cluster scaffold homolog (E. coli) (Iscu)
  • IscU iron-sulfur cluster scaffold homolog (E. coli) (Iscu)
  • 2310020H20Rik protein
  • AA407971 protein
  • HML protein
  • hnifU protein
  • ISU2 protein
  • Nifu protein
  • Nifun protein
  • RGD1309562 protein
  • si:ch211-191d15.3 protein
  • zC191D15.3 protein

Protein level used designations for ISCU

iron-sulfur cluster assembly enzyme ISCU, mitochondrial , iron-sulfur cluster scaffold homolog (E. coli) , iron-sulfur cluster assembly enzyme , IscU iron-sulfur cluster scaffold homolog (E. coli) , NifU-like N-terminal domain containing , zC191D15.3 (novel protein with leucine-rich repeat domains) , IscU iron-sulfur cluster scaffold homolog , iron-sulfur cluster scaffold homolog , nifU-like N-terminal domain-containing protein , nifU-like protein , ISCU2

GENE ID SPECIES
409130 Apis mellifera
477527 Canis lupus familiaris
514789 Bos taurus
497179 Danio rerio
23479 Homo sapiens
288740 Rattus norvegicus
66383 Mus musculus
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