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Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. Additionally we are shipping and many more products for this protein.
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ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (show TP53 Proteins) mutation.
Thus, driven by acquired (hypoxia) or genetic causes, the miR (show MLXIP Proteins)-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing iron-sulfur deficiency and pulmonary hypertension.
The core Fe-S biosynthetic enzymatic complex generated [2Fe-2S] cluster intermediates that converted to stable [2Fe-2S] clusters bound to uncomplexed ISCU2.
IscU is a new substrate of MK2 (show KCNA2 Proteins) both in Drosophila cells and in human cells
Fe-S assembly protein (ISCU2) and frataxin (show FXN Proteins) convert substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.
the G50E iron-sulfur cluster scaffold protein (show NFU1 Proteins) (ISCU) mutation has a role in mitochondrial myopathy
NFS1 (show NFS1 Proteins) binds preferentially to the D-state of ISCU while mtHSP70 (show HSPA9 Proteins) binds preferentially to the D-state of ISCU and HSC20 (show HSCB Proteins) binds preferentially to the S-state of ISCU.
mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.
MicroRNA-210 correlates negatively with its gene target ISCU at the protein and mRNA level. MicroRNA-210 correlated with positive outcome variables
ISCU protein deficiency in patients results from muscle-specific (show EIF3K Proteins) mis (show AMH Proteins)-splicing and oxidative stress.
Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.
IscU iron-sulfur cluster scaffold homolog
, NifU-like N-terminal domain containing
, iron-sulfur cluster assembly enzyme ISCU, mitochondrial
, iron-sulfur cluster scaffold homolog
, nifU-like N-terminal domain-containing protein
, nifU-like protein