anti-Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) Antibodies

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. Additionally we are shipping ISCU Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
ISCU 23479 Q9H1K1
ISCU 288740  
ISCU 66383 Q9D7P6
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Top anti-ISCU Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Iscu Antibody Titration: 1.0 ug/ml Positive Control: Rat Lung 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB ISCU Antibody (C-term) (ABIN1881467) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the ISCU antibody detected the ISCU protein (arrow). ISCU Antibody (C-term) (ABIN1881467) western blot analysis in mouse lung tissue lysates (35 µg/lane). This demonstrates the ISCU antibody detected the ISCU protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, ELISA, WB Immunofluorescence of monoclonal antibody to NIFUN on HeLa cell. [antibody concentration 10 ug/ml] NIFUN monoclonal antibody (M01), clone 3B8-1C4 Western Blot analysis of NIFUN expression in HL-60 . 100 μg Log in to see 11 to 12 Days
$430.00
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: ISCU Antibody [NBP2-14998] - Paraffin-embedded A549 xenograft, using antibody at 1:500 dilution. Immunocytochemistry/Immunofluorescence: ISCU Antibody [NBP2-14998] - Analysis of methanol-fixed HeLa, using antibody at 1:200 dilution. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to NIFUN on HeLa cell (antibody concentration 10 µg/mL). NIFUN monoclonal antibody (M01), clone 3B8-1C4 Western Blot analysis of NIFUN expression in HL-60. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Mouse Un-conjugated IHC, WB Immunohistochemistry: ISCU Antibody (4F5) [NBP2-45436] - Analysis of Carcinoma of Human pancreas tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) Immunohistochemistry: ISCU Antibody (4F5) [NBP2-45436] - Analysis of Carcinoma of Human thyroid tissue. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min) 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Rat Rabbit Un-conjugated WB Western Blot: ISCU Antibody [NBP1-74072] - Rat Lung Lysate 1ug/ml Gel Concentration 10-20% 100 μL Log in to see 8 to 11 Days
$447.56
Details
Human Mouse Un-conjugated IHC (p), WB   100 μL Log in to see 7 to 9 Days
$493.17
Details
Human Mouse Un-conjugated WB   100 μL Log in to see 7 to 9 Days
$493.17
Details

ISCU Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Rat (Rattus)


Mouse (Murine)


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Top referenced anti-ISCU Antibodies

  1. Human Polyclonal ISCU Primary Antibody for WB - ABIN1881467 : Chan, Zhang, Hemann, Mahoney, Zweier, Loscalzo: MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. in Cell metabolism 2009 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal ISCU Primary Antibody for IF, ELISA - ABIN565100 : Heather, Cole, Tan, Ambrose, Pope, Abd-Jamil, Carter, Dodd, Yeoh, Schofield, Clarke: Metabolic adaptation to chronic hypoxia in cardiac mitochondria. in Basic research in cardiology 2012 (PubMed)

More Antibodies against ISCU Interaction Partners

Human Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. We have shown that ASO treatment diminished aberrant splicing and increased ISCU protein levels in both patient fibroblasts and patient myotubes in a concentration dependent fashion. Upon ASO treatment, levels of SDHB (show SDHB Antibodies) in patient myotubular cell lines increased to levels observed in control myotubular cell lines

  2. The NFS1 (show NFS1 Antibodies)/ISD11 (show LYRM4 Antibodies) complex further interacts with scaffold protein (show HOMER1 Antibodies) ISCU and regulator protein frataxin (show FXN Antibodies), thereby forming a quaternary complex for Fe-S cluster formation.

  3. Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN (show FXN Antibodies)(42-210)]24.[NFS1 (show NFS1 Antibodies)]24.[ISD11 (show LYRM4 Antibodies)]24.[ISCU]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components.

  4. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (show TP53 Antibodies) mutation.

  5. Thus, driven by acquired (hypoxia) or genetic causes, the miR (show MLXIP Antibodies)-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing iron-sulfur deficiency and pulmonary hypertension.

  6. The core Fe-S biosynthetic enzymatic complex generated [2Fe-2S] cluster intermediates that converted to stable [2Fe-2S] clusters bound to uncomplexed ISCU2.

  7. IscU is a new substrate of MK2 (show KCNA2 Antibodies) both in Drosophila cells and in human cells

  8. Fe-S assembly protein (ISCU2) and frataxin (show FXN Antibodies) convert substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.

  9. the G50E iron-sulfur cluster scaffold protein (show NFU1 Antibodies) (ISCU) mutation has a role in mitochondrial myopathy

  10. NFS1 (show NFS1 Antibodies) binds preferentially to the D-state of ISCU while mtHSP70 (show HSPA9 Antibodies) binds preferentially to the D-state of ISCU and HSC20 (show HSCB Antibodies) binds preferentially to the S-state of ISCU.

Mouse (Murine) Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (show TP53 Antibodies) mutation.

  2. IscU is a marginally stable protein at low ionic strength to the point that undergoes cold denaturation at around -8 degrees C with a corresponding dramatic decrease of enthalpy, which is consistent with the fluxional nature of the protein.

  3. mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.

  4. Data show that complete loss of ISCU results in early embryonic death and confirm a fundamental role for ISCU in mammals.

  5. While IFN-gamma (show IFNG Antibodies) alone induced Nfs1 (show NFS1 Antibodies) protein instability, LPS (show TLR4 Antibodies) triggered a delayed decline of Nfs1 (show NFS1 Antibodies), rather involving transcriptional events or mRNA instability.

ISCU Antigen Profile

Protein Summary

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

Gene names and symbols associated with ISCU

  • iron-sulfur cluster assembly enzyme ISCU, mitochondrial (Iscu) antibody
  • iron-sulfur cluster scaffold homolog (E. coli) (ISCU) antibody
  • IscU iron-sulfur cluster scaffold homolog (E. coli) (iscu) antibody
  • iron-sulfur cluster assembly enzyme (ISCU) antibody
  • iron-sulfur cluster scaffold homolog (E. coli) (Iscu) antibody
  • IscU iron-sulfur cluster scaffold homolog (E. coli) (Iscu) antibody
  • 2310020H20Rik antibody
  • AA407971 antibody
  • HML antibody
  • hnifU antibody
  • ISU2 antibody
  • Nifu antibody
  • Nifun antibody
  • RGD1309562 antibody
  • si:ch211-191d15.3 antibody
  • zC191D15.3 antibody

Protein level used designations for ISCU

iron-sulfur cluster assembly enzyme ISCU, mitochondrial , iron-sulfur cluster scaffold homolog (E. coli) , iron-sulfur cluster assembly enzyme , IscU iron-sulfur cluster scaffold homolog (E. coli) , NifU-like N-terminal domain containing , zC191D15.3 (novel protein with leucine-rich repeat domains) , IscU iron-sulfur cluster scaffold homolog , iron-sulfur cluster scaffold homolog , nifU-like N-terminal domain-containing protein , nifU-like protein , ISCU2

GENE ID SPECIES
409130 Apis mellifera
477527 Canis lupus familiaris
514789 Bos taurus
497179 Danio rerio
23479 Homo sapiens
288740 Rattus norvegicus
66383 Mus musculus
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