Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) ELISA Kits

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. Additionally we are shipping ISCU Antibodies (59) and ISCU Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Human ISCU ISCU 23479 Q9H1K1
Anti-Rat ISCU ISCU 288740  
Anti-Mouse ISCU ISCU 66383 Q9D7P6
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More ELISA Kits for ISCU Interaction Partners

Human Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. We have shown that ASO treatment diminished aberrant splicing and increased ISCU protein levels in both patient fibroblasts and patient myotubes in a concentration dependent fashion. Upon ASO treatment, levels of SDHB (show SDHB ELISA Kits) in patient myotubular cell lines increased to levels observed in control myotubular cell lines

  2. The NFS1 (show NFS1 ELISA Kits)/ISD11 (show LYRM4 ELISA Kits) complex further interacts with scaffold protein (show HOMER1 ELISA Kits) ISCU and regulator protein frataxin (show FXN ELISA Kits), thereby forming a quaternary complex for Fe-S cluster formation.

  3. Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN (show FXN ELISA Kits)(42-210)]24.[NFS1 (show NFS1 ELISA Kits)]24.[ISD11 (show LYRM4 ELISA Kits)]24.[ISCU]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components.

  4. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (show TP53 ELISA Kits) mutation.

  5. Thus, driven by acquired (hypoxia) or genetic causes, the miR (show MLXIP ELISA Kits)-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing iron-sulfur deficiency and pulmonary hypertension.

  6. The core Fe-S biosynthetic enzymatic complex generated [2Fe-2S] cluster intermediates that converted to stable [2Fe-2S] clusters bound to uncomplexed ISCU2.

  7. IscU is a new substrate of MK2 (show KCNA2 ELISA Kits) both in Drosophila cells and in human cells

  8. Fe-S assembly protein (ISCU2) and frataxin (show FXN ELISA Kits) convert substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.

  9. the G50E iron-sulfur cluster scaffold protein (show NFU1 ELISA Kits) (ISCU) mutation has a role in mitochondrial myopathy

  10. NFS1 (show NFS1 ELISA Kits) binds preferentially to the D-state of ISCU while mtHSP70 (show HSPA9 ELISA Kits) binds preferentially to the D-state of ISCU and HSC20 binds preferentially to the S-state of ISCU.

Mouse (Murine) Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (show TP53 ELISA Kits) mutation.

  2. IscU is a marginally stable protein at low ionic strength to the point that undergoes cold denaturation at around -8 degrees C with a corresponding dramatic decrease of enthalpy, which is consistent with the fluxional nature of the protein.

  3. mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.

  4. Data show that complete loss of ISCU results in early embryonic death and confirm a fundamental role for ISCU in mammals.

  5. While IFN-gamma (show IFNG ELISA Kits) alone induced Nfs1 (show NFS1 ELISA Kits) protein instability, LPS (show TLR4 ELISA Kits) triggered a delayed decline of Nfs1 (show NFS1 ELISA Kits), rather involving transcriptional events or mRNA instability.

ISCU Antigen Profile

Antigen Summary

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

Gene names and symbols associated with ISCU

  • iron-sulfur cluster assembly enzyme ISCU, mitochondrial (Iscu) antibody
  • iron-sulfur cluster scaffold homolog (E. coli) (ISCU) antibody
  • IscU iron-sulfur cluster scaffold homolog (E. coli) (iscu) antibody
  • iron-sulfur cluster assembly enzyme (ISCU) antibody
  • iron-sulfur cluster scaffold homolog (E. coli) (Iscu) antibody
  • IscU iron-sulfur cluster scaffold homolog (E. coli) (Iscu) antibody
  • 2310020H20Rik antibody
  • AA407971 antibody
  • HML antibody
  • hnifU antibody
  • ISU2 antibody
  • Nifu antibody
  • Nifun antibody
  • RGD1309562 antibody
  • si:ch211-191d15.3 antibody
  • zC191D15.3 antibody

Protein level used designations for ISCU

iron-sulfur cluster assembly enzyme ISCU, mitochondrial , iron-sulfur cluster scaffold homolog (E. coli) , iron-sulfur cluster assembly enzyme , IscU iron-sulfur cluster scaffold homolog (E. coli) , NifU-like N-terminal domain containing , zC191D15.3 (novel protein with leucine-rich repeat domains) , IscU iron-sulfur cluster scaffold homolog , iron-sulfur cluster scaffold homolog , nifU-like N-terminal domain-containing protein , nifU-like protein , ISCU2

GENE ID SPECIES
409130 Apis mellifera
477527 Canis lupus familiaris
514789 Bos taurus
497179 Danio rerio
23479 Homo sapiens
288740 Rattus norvegicus
66383 Mus musculus
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