Iron-Sulfur Cluster Scaffold Homolog (E. Coli) Proteins (ISCU)

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. Additionally we are shipping ISCU Antibodies (59) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ISCU 23479 Q9H1K1
Rat ISCU ISCU 288740  
ISCU 66383 Q9D7P6
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Top ISCU Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Escherichia coli (E. coli) Human His tag 10 μg Log in to see 15 to 19 Days
$319.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Shigella flexneri His tag   1 mg Log in to see 60 to 71 Days
$2,262.33
Details
Escherichia coli (E. coli) Human Un-conjugated   10 μg Log in to see 2 to 3 Days
$364.64
Details

ISCU Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) Interaction Partners

Human Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. We have shown that ASO treatment diminished aberrant splicing and increased ISCU protein levels in both patient fibroblasts and patient myotubes in a concentration dependent fashion. Upon ASO treatment, levels of SDHB (show SDHB Proteins) in patient myotubular cell lines increased to levels observed in control myotubular cell lines

  2. The NFS1 (show NFS1 Proteins)/ISD11 (show LYRM4 Proteins) complex further interacts with scaffold protein (show HOMER1 Proteins) ISCU and regulator protein frataxin (show FXN Proteins), thereby forming a quaternary complex for Fe-S cluster formation.

  3. Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN (show FXN Proteins)(42-210)]24.[NFS1 (show NFS1 Proteins)]24.[ISD11 (show LYRM4 Proteins)]24.[ISCU]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components.

  4. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (show TP53 Proteins) mutation.

  5. Thus, driven by acquired (hypoxia) or genetic causes, the miR (show MLXIP Proteins)-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing iron-sulfur deficiency and pulmonary hypertension.

  6. The core Fe-S biosynthetic enzymatic complex generated [2Fe-2S] cluster intermediates that converted to stable [2Fe-2S] clusters bound to uncomplexed ISCU2.

  7. IscU is a new substrate of MK2 (show KCNA2 Proteins) both in Drosophila cells and in human cells

  8. Fe-S assembly protein (ISCU2) and frataxin (show FXN Proteins) convert substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.

  9. the G50E iron-sulfur cluster scaffold protein (show NFU1 Proteins) (ISCU) mutation has a role in mitochondrial myopathy

  10. NFS1 (show NFS1 Proteins) binds preferentially to the D-state of ISCU while mtHSP70 (show HSPA9 Proteins) binds preferentially to the D-state of ISCU and HSC20 (show HSCB Proteins) binds preferentially to the S-state of ISCU.

Mouse (Murine) Iron-Sulfur Cluster Scaffold Homolog (E. Coli) (ISCU) interaction partners

  1. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (show TP53 Proteins) mutation.

  2. IscU is a marginally stable protein at low ionic strength to the point that undergoes cold denaturation at around -8 degrees C with a corresponding dramatic decrease of enthalpy, which is consistent with the fluxional nature of the protein.

  3. mTORC1 associates with ISCU and phosphorylates ISCU at serine 14. This phosphorylation stabilized ISCU protein.

  4. Data show that complete loss of ISCU results in early embryonic death and confirm a fundamental role for ISCU in mammals.

  5. While IFN-gamma (show IFNG Proteins) alone induced Nfs1 (show NFS1 Proteins) protein instability, LPS (show TLR4 Proteins) triggered a delayed decline of Nfs1 (show NFS1 Proteins), rather involving transcriptional events or mRNA instability.

ISCU Protein Profile

Protein Summary

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

Gene names and symbols associated with ISCU

  • iron-sulfur cluster assembly enzyme ISCU, mitochondrial (LOC409130)
  • iron-sulfur cluster assembly enzyme (ISCU)
  • iron-sulfur cluster assembly enzyme a (iscua)
  • iron-sulfur cluster assembly enzyme (Iscu)
  • 2310020H20Rik protein
  • AA407971 protein
  • HML protein
  • hnifU protein
  • ISU2 protein
  • Nifu protein
  • Nifun protein
  • RGD1309562 protein
  • si:ch211-191d15.3 protein
  • zC191D15.3 protein

Protein level used designations for ISCU

iron-sulfur cluster assembly enzyme ISCU, mitochondrial , iron-sulfur cluster scaffold homolog (E. coli) , iron-sulfur cluster assembly enzyme , IscU iron-sulfur cluster scaffold homolog (E. coli) , NifU-like N-terminal domain containing , zC191D15.3 (novel protein with leucine-rich repeat domains) , IscU iron-sulfur cluster scaffold homolog , iron-sulfur cluster scaffold homolog , nifU-like N-terminal domain-containing protein , nifU-like protein , ISCU2

GENE ID SPECIES
409130 Apis mellifera
477527 Canis lupus familiaris
514789 Bos taurus
497179 Danio rerio
23479 Homo sapiens
288740 Rattus norvegicus
66383 Mus musculus
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