Iron-Sulfur Cluster Scaffold Homolog Proteins (ISCU)

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. Additionally we are shipping and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ISCU 23479 Q9H1K1
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Catalog No. Origin Source Conjugate Quantity Supplier Delivery Price Details
Human Un-conjugated 1 μg Log in to see 6 Days
$168.54
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More Proteins for Iron-Sulfur Cluster Scaffold Homolog (ISCU) Interaction Partners

Human Iron-Sulfur Cluster Scaffold Homolog (ISCU) interaction partners

  1. We have shown that ASO treatment diminished aberrant splicing and increased ISCU protein levels in both patient fibroblasts and patient myotubes in a concentration dependent fashion. Upon ASO treatment, levels of SDHB (show SDHB Proteins) in patient myotubular cell lines increased to levels observed in control myotubular cell lines

  2. The NFS1 (show NFS1 Proteins)/ISD11 (show LYRM4 Proteins) complex further interacts with scaffold protein (show HOMER1 Proteins) ISCU and regulator protein frataxin (show FXN Proteins), thereby forming a quaternary complex for Fe-S cluster formation.

  3. Molecular dynamics flexible fitting of protein structures docked into the EM map of the model revealed a [FXN (show FXN Proteins)(42-210)]24.[NFS1 (show NFS1 Proteins)]24.[ISD11 (show LYRM4 Proteins)]24.[ISCU]24 complex, consistent with the measured 1:1:1:1 stoichiometry of its four components.

  4. ISCU expression was decreased in the majority of human liver cancer tissues, and its reduced expression was significantly associated with p53 (show TP53 Proteins) mutation.

  5. Thus, driven by acquired (hypoxia) or genetic causes, the miR (show MLXIP Proteins)-210-ISCU1/2 regulatory axis is a pathogenic lynchpin causing iron-sulfur deficiency and pulmonary hypertension.

  6. The core Fe-S biosynthetic enzymatic complex generated [2Fe-2S] cluster intermediates that converted to stable [2Fe-2S] clusters bound to uncomplexed ISCU2.

  7. IscU is a new substrate of MK2 (show KCNA2 Proteins) both in Drosophila cells and in human cells

  8. Fe-S assembly protein (ISCU2) and frataxin (show FXN Proteins) convert substrates l-cysteine, ferrous iron, and electrons into Fe-S clusters.

  9. the G50E iron-sulfur cluster scaffold protein (show NFU1 Proteins) (ISCU) mutation has a role in mitochondrial myopathy

  10. NFS1 (show NFS1 Proteins) binds preferentially to the D-state of ISCU while mtHSP70 (show HSPA9 Proteins) binds preferentially to the D-state of ISCU and HSC20 (show HSCB Proteins) binds preferentially to the S-state of ISCU.

ISCU Protein Profile

Protein Summary

Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.

Gene names and symbols associated with ISCU

  • iron-sulfur cluster assembly enzyme (ISCU)
  • 2310020H20Rik protein
  • HML protein
  • hnifU protein
  • ISU2 protein
  • NIFU protein
  • NIFUN protein

Protein level used designations for ISCU

IscU iron-sulfur cluster scaffold homolog , NifU-like N-terminal domain containing , iron-sulfur cluster assembly enzyme ISCU, mitochondrial , iron-sulfur cluster scaffold homolog , nifU-like N-terminal domain-containing protein , nifU-like protein

GENE ID SPECIES
23479 Homo sapiens
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