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Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. Additionally we are shipping Islet Amyloid Polypeptide Kits (80) and Islet Amyloid Polypeptide Proteins (9) and many more products for this protein.
Showing 10 out of 121 products:
Human Monoclonal IAPP Primary Antibody for IHC (fro), IF - ABIN118954
Gong, Liu, Zeng, Peng, Chen, Zhou, Li: Amylin deposition in the kidney of patients with diabetic nephropathy. in Kidney international 2007
Show all 7 references for ABIN118954
Cat (Feline) Polyclonal IAPP Primary Antibody for IHC (fro), IHC (p) - ABIN115737
Mulder, Ahrén, Stridsberg, Sundler: Non-parallelism of islet amyloid polypeptide (amylin) and insulin gene expression in rats islets following dexamethasone treatment. in Diabetologia 1995
Show all 2 references for ABIN115737
Human Polyclonal IAPP Primary Antibody for WB - ABIN610646
Cifuentes-Diaz, Frugier, Tiziano, Lacène, Roblot, Joshi, Moreau, Melki: Deletion of murine SMN exon 7 directed to skeletal muscle leads to severe muscular dystrophy. in The Journal of cell biology 2001
Show all 2 references for ABIN610646
Human Polyclonal IAPP Primary Antibody for WB - ABIN516766
Ladiwala, Bhattacharya, Perchiacca, Cao, Raleigh, Abedini, Schmidt, Varkey, Langen, Tessier: Rational design of potent domain antibody inhibitors of amyloid fibril assembly. in Proceedings of the National Academy of Sciences of the United States of America 2012
Data suggest that IAPP/membrane interaction strongly depends on protonation state of His18; at neutral pH, N-terminal domain is stabilized/anchored to membrane, while C-terminal domain is disordered as if in solution.
Structural studies and cytotoxicity assays of "aggregation-prone" IAPP(8-16) and its non-amyloidogenic variants suggest its important role in fibrillogenesis and cytotoxicity of human amylin.
Hsp72 (HSPA1A (show HSPA1A Antibodies)) prevents h-IAPP aggregation and toxicity.
structural and dynamical information of amylin and CGRP (show S100A12 Antibodies)
The computational models support the cross-sequence interactions between ABETA (show APP Antibodies) and IAPP pentamers, which would lead to the complex hybrid ABETA (show APP Antibodies)-IAPP assemblies.
Study focused on human islet amyloid polypeptide aggregates and a de novo designed short polypeptide at lipid/water and air/glass interfaces; found that parallel beta-sheets adopt distinct orientations at various interfaces and exhibit characteristic chiroptical responses in the amide I and N-H stretch regions.
Secondary Structure of Rat and Human Amylin
Matrix Metalloproteinase-9 (show MMP9 Antibodies) Protects Islets from Amyloid-induced Toxicity.
combined computational and experimental study offers detailed mechanistic insight into the complex role of zinc on IAPP aggregation and T2D development
When copper(II) was present in the solution, no dimers were detected. Thus, the copper(II) ions disrupt the association pathway to the formation of beta-sheet rich amylin fibrils.
Data indicate that T-cell receptors that react to chromogranin A (ChgA (show CHGA Antibodies)) and islet amyloid polypeptide precursor (IAPP) autoantigens were impaired when the thymic stromal cells lacked thymus-specific serine protease (TSSP (show PRSS16 Antibodies)).
Study the physiologic actions of IAPP on pancreatic beta cells, which secrete this peptide together with insulin (show INS Antibodies) upon glucose stimulation. Explore the signaling pathways and mitogenic actions of IAPP on beta cells.
deletion of the DeltaN isoforms of p63 (show CKAP4 Antibodies) or p73 (show ARHGAP24 Antibodies) leads to metabolic reprogramming and regression of p53 (show TP53 Antibodies)-deficient tumours through upregulation of IAPP, the gene that encodes amylin, a 37-amino-acid peptide co-secreted with insulin (show INS Antibodies) by the beta cells of the pancreas
The stability, conformational dynamics and association force of different single-layer models of the full-length wild-type and glycine mutants of amylin, were investigated.
studies have identified a novel TXNIP (show TXNIP Antibodies)/miR (show MLXIP Antibodies)-124a/FoxA2 (show FOXA2 Antibodies)/IAPP signaling cascade linking the critical beta-cell signaling pathways of TXNIP (show TXNIP Antibodies) and IAPP
MMP-9 (show MMP9 Antibodies) constitutes an endogenous islet protease that limits islet amyloid deposition and its toxic effects via degradation of hIAPP.
Data suggest that amylin and leptin (show LEP Antibodies) play additive roles in regulating energy homeostasis via activation of overlapping signalling pathways; mechanisms may be different in hypothalamus, muscle, and liver and in cases of endoplasmic reticulum stress.
MCP-1 (show CPT1B Antibodies) induces amylin expression through ERK1/2 (show MAPK1/3 Antibodies)/JNK (show MAPK8 Antibodies)-AP1 (show JUN Antibodies) and NF-kappaB (show NFKB1 Antibodies) related signaling pathways independent of CCR2 (show CCR2 Antibodies). Amylin upregulation by MCP-1 (show CPT1B Antibodies) may contribute to elevation of plasma amylin in obesity and insulin (show INS Antibodies) resistance
This study demonstrated that amylin inactivation leads to a low bone mass due to an increase in bone resorption whereas bone formation is unaffected.
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
islet amyloid polypeptide
, Islet amyloid polypeptide (diabetes-associated peptide; amylin)
, diabetes-associated peptide
, insulinoma amyloid peptide
, amyloid protein