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Isocitrate Dehydrogenase 1 (NADP+), Soluble Proteins (IDH1)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH1 Antibodies (189) and IDH1 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDH1 3417 O75874
IDH1 15926 O88844
IDH1 24479 P41562
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Top IDH1 Proteins at antibodies-online.com

Showing 10 out of 14 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$383.25
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$745.80
Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$774.40
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag   0.05 mg Log in to see 2 to 3 Days
$515.63
Details

IDH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)
,
Rat (Rattus) ,

Top referenced IDH1 Proteins

  1. Human IDH1 Protein expressed in Escherichia coli (E. coli) - ABIN2181246 : Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: Lysine acetylation targets protein complexes and co-regulates major cellular functions. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 4 references for ABIN2181246

  2. Human IDH1 Protein expressed in Escherichia coli (E. coli) - ABIN667603 : Thorsness, Koshland: Inactivation of isocitrate dehydrogenase by phosphorylation is mediated by the negative charge of the phosphate. in The Journal of biological chemistry 1987 (PubMed)
    Show all 2 references for ABIN667603

More Proteins for Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaction Partners

Human Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Data indicate a significant effect only in one scenario, the interaction between temozolomide (TMZ) and R132H mutations in isocitrate dehydrogenase (IDH1) on the overall survival of lower-grade glioma (LGG)

  2. alterations in genetic regulatory mechanisms may be the key factor for the major phenotypic changes in IDH1 mutated gliomas

  3. Data show that the monitoring of isocitrate dehydrogenase (NADP(+)) 1/2 IDH1/2 mutations showed that these mutations were reliable minimal residual disease (MRD) markers that allowed the prediction of relapse in the majority of patients.

  4. Case Report: right cerebellar pilocytic astrocytoma WHO grade I with an IDH1 R132H mutation.

  5. Data indicate that isocitrate dehydrogenase (NADP(+)) 1 (IDH1) mutation is a positive prognostic marker for low-grade glioma patients.

  6. Mutations in IDH1 gene conferred resistance to Temozolomide in glioblastoma.

  7. The combined use of IDH1 mutation and MGMT (show MGMT Proteins) methylation status can be used as prognostic markers for long-term survival of patients with cerebral low-grade glioma.

  8. mmunohistochemistry can be used for evaluation of ATRX (show ATRX Proteins) loss, p53 (show TP53 Proteins) protein accumulation and IDH1R132H mutation, which may allow a means of classification of astrocytoma outcome

  9. Mutations in isocitrate dehydrogenase 1 with high d-2-hydroxyglutarate serum levels are associated with acute myeloid leukemia (show BCL11A Proteins).

  10. IDH1 mutations are associated with myelodysplastic syndromes.

Mouse (Murine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells

  2. The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH (show FDXR Proteins) ratio.

  3. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H.

  4. MiR (show MLXIP Proteins)-181a regulates lipid metabolism via IDH1

  5. revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity.

  6. these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas.

  7. WA might exert its chemopreventive activity via inhibiting not only oncogenic activation, but also IDH1 inactivation.

  8. Brain-specific (show CALY Proteins) Idh1-KI mice show brain hemorrhage accompanied by high D2HG levels but decreased ROS (show ROS1 Proteins)

  9. Suggest that decreased IDPc expression renders melanocytes more vulnerable to oxidative stress, and IDPc plays an important antioxidant function in melanocytes.

  10. Absence of IDH1 mutations in low-grade gliomas (LGGs) identifies a novel entity of LGGs with distinctive location, infiltrative behavior, specific molecular alterations, and dismal outcome.

Cow (Bovine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Data suggest that the expression of cytosolic NADP+-dependent isocitrate dehydrogenase in bovine mammary epithelium is modulated by regulators of differentiation including extracellular matrix and lactogenic hormones as well as metabolic effectors.

Pig (Porcine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  3. These results suggest that IDPm (show IDH2 Proteins) plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Proteins) activity.

IDH1 Protein Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Gene names and symbols associated with IDH1

  • isocitrate dehydrogenase 1 (NADP+), soluble (IDH1)
  • isocitrate dehydrogenase 1 (NADP+), soluble (Idh1)
  • isocitrate dehydrogenase 1 (NADP+), soluble (idh1)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2)
  • AI314845 protein
  • AI788952 protein
  • cb876 protein
  • E030024J03Rik protein
  • fm90e09 protein
  • Id-1 protein
  • IDCD protein
  • IDH protein
  • Idh-1 protein
  • IDP protein
  • Idpc protein
  • im:7143416 protein
  • NADP-CICDH protein
  • PICD protein
  • wu:fm90e09 protein

Protein level used designations for IDH1

isocitrate dehydrogenase 1 (NADP+), soluble , isocitrate dehydrogenase [NADP] cytoplasmic-like , NADP(+)-specific ICDH , NADP-dependent isocitrate dehydrogenase, cytosolic , NADP-dependent isocitrate dehydrogenase, peroxisomal , isocitrate dehydrogenase [NADP] cytoplasmic , oxalosuccinate decarboxylase , IDH , IDP , cytosolic NADP-isocitrate dehydrogenase , isocitrate dehydrogenase 1 , Isocitrate dehydrogenase 1, soluble , ICD-M , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase [NADP], mitochondrial

GENE ID SPECIES
478889 Canis lupus familiaris
751618 Felis catus
100414768 Callithrix jacchus
3417 Homo sapiens
15926 Mus musculus
494713 Xenopus laevis
100328559 Oryctolagus cuniculus
24479 Rattus norvegicus
281235 Bos taurus
100006589 Danio rerio
100170146 Sus scrofa
443257 Ovis aries
397603 Sus scrofa
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