Isocitrate Dehydrogenase 1 (NADP+), Soluble Proteins (IDH1)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH1 Antibodies (207) and IDH1 Kits (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDH1 3417 O75874
IDH1 15926 O88844
IDH1 24479 P41562
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Top IDH1 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag Human IDH1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Log in to see 2 to 3 Days
$275.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$340.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$678.00
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HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$736.00
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details
HOST_Human Human His tag   10 μg Log in to see 15 to 16 Days
$300.00
Details

IDH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
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Mouse (Murine) ,
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Rat (Rattus) ,

Top referenced IDH1 Proteins

  1. Human IDH1 Protein expressed in Escherichia coli (E. coli) - ABIN2181246 : Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: Lysine acetylation targets protein complexes and co-regulates major cellular functions. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 4 references for 2181246

  2. Human IDH1 Protein expressed in Escherichia coli (E. coli) - ABIN667603 : Thorsness, Koshland: Inactivation of isocitrate dehydrogenase by phosphorylation is mediated by the negative charge of the phosphate. in The Journal of biological chemistry 1987 (PubMed)
    Show all 2 references for 667603

More Proteins for Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaction Partners

Human Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. IDH1 mutation is associated with high-grade gliomas.

  2. six out of six recurrent and IDH1 mutated grade III tumors also showed XAF1 (show XAF1 Proteins) promoter methylation

  3. IDH1 R132C mutation is associated with clear cell hepatocellular carcinoma.

  4. Identification of IDH1 or IDH2 (show IDH2 Proteins) mutations supports the diagnosis of dedifferentiated chondrosarcoma rather than undifferentiated pleomorphic sarcoma of bone.

  5. The data of this study suggested that mutant IDH1 has potent antithrombotic activity within gliomas and throughout the peripheral circulation.

  6. This retrospective analysis suggested that the presence of an IDH1 (R132H) mutation, frontal tumor location, and WHO grade of the initial tumor are associated with OS after progression to secondary glioblastoma.

  7. Expression of mutant IDH1 suppresses the accumulation of T cells in glioma tumor sites.

  8. Study describes the development of a highly specific and first potent pan-inhibitor of all IDH1R132 mutations (BAY 1436032) with favorable pharmacological and pharmacokinetic properties.

  9. Results showed that TERT promoter mutational status combined with IDH-mutation allowed simple classification of grade II/III gliomas for stratifying patients and clarifying diagnostic accuracy by supplementing standard histopathological criteria.

  10. the mutant IDH1 protein is a stronger oncogene (show RAB1A Proteins) than R-2HG alone when comparable intracellular R-2HG levels are achieved

Mouse (Murine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. IDH1 mutations caused down-regulation of leukocyte chemotaxis, resulting in repression of the tumor-associated immune system.

  2. Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagenesis

  3. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC self-renewal, independent of TET2.

  4. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1 (show ACO1 Proteins), enzymes involved in the TCA cycle, were elevated.

  5. data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells

  6. The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

  7. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H.

  8. MiR (show MLXIP Proteins)-181a regulates lipid metabolism via IDH1

  9. revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity.

  10. these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas.

Cow (Bovine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Data suggest that the expression of cytosolic NADP+-dependent isocitrate dehydrogenase in bovine mammary epithelium is modulated by regulators of differentiation including extracellular matrix and lactogenic hormones as well as metabolic effectors.

Pig (Porcine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  3. These results suggest that IDPm (show IDH2 Proteins) plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Proteins) activity.

IDH1 Protein Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Gene names and symbols associated with IDH1

  • isocitrate dehydrogenase 1 (NADP+), soluble (IDH1)
  • isocitrate dehydrogenase 1 (NADP+), soluble (Idh1)
  • isocitrate dehydrogenase 1 (NADP+), soluble (idh1)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2)
  • AI314845 protein
  • AI788952 protein
  • cb876 protein
  • E030024J03Rik protein
  • fm90e09 protein
  • Id-1 protein
  • IDCD protein
  • IDH protein
  • Idh-1 protein
  • IDP protein
  • Idpc protein
  • im:7143416 protein
  • NADP-CICDH protein
  • PICD protein
  • wu:fm90e09 protein

Protein level used designations for IDH1

isocitrate dehydrogenase 1 (NADP+), soluble , isocitrate dehydrogenase [NADP] cytoplasmic-like , NADP(+)-specific ICDH , NADP-dependent isocitrate dehydrogenase, cytosolic , NADP-dependent isocitrate dehydrogenase, peroxisomal , isocitrate dehydrogenase [NADP] cytoplasmic , oxalosuccinate decarboxylase , IDH , IDP , cytosolic NADP-isocitrate dehydrogenase , isocitrate dehydrogenase 1 , Isocitrate dehydrogenase 1, soluble , ICD-M , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase [NADP], mitochondrial

GENE ID SPECIES
478889 Canis lupus familiaris
751618 Felis catus
100414768 Callithrix jacchus
3417 Homo sapiens
15926 Mus musculus
494713 Xenopus laevis
100328559 Oryctolagus cuniculus
24479 Rattus norvegicus
281235 Bos taurus
100006589 Danio rerio
100170146 Sus scrofa
443257 Ovis aries
397603 Sus scrofa
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