Isocitrate Dehydrogenase 1 (NADP+), Soluble Proteins (IDH1)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH1 Antibodies (210) and IDH1 Kits (24) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDH1 3417 O75874
IDH1 15926 O88844
IDH1 24479 P41562
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Top IDH1 Proteins at antibodies-online.com

Showing 10 out of 16 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,960.83
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$678.00
Details
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 15 to 18 Days
$704.00
Details
Escherichia coli (E. coli) Human His tag Human IDH1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Log in to see 2 to 3 Days
$275.00
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 2 to 3 Days
$340.00
Details
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,147.83
Details
Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$736.00
Details
Escherichia coli (E. coli) Human His tag 10 μg Log in to see 20 to 21 Days
$250.80
Details

IDH1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
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Mouse (Murine) ,
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Rat (Rattus) ,

More Proteins for Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaction Partners

Human Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. IDH1/2 mutations induce a homologous recombination defect that renders tumor cells exquisitely sensitive to poly(adenosine 5'-diphosphate-ribose) polymerase inhibitors

  2. To confirm this result, we analyzed survival data from 142 LGGs from TCGA with IDH1/IDH2 (show IDH2 Proteins) mutations and no 1p19q codeletion. Despite the high rate of censured data, we found that CNLOH 17p, including the TP53 (show TP53 Proteins) locus, was associated with better outcome (OR = 0.27; p = .026)

  3. Results suggest that to better treat gliomas, isocitrate dehydrogenase (NADP(+)) 1 (IDH-1) mutation status should be included when determining WHO2007 grade in glioma patients.

  4. The found of this study suggest that IDH1 mutation status had greater impact than histological and other genomic features on miRNA expression patterns.

  5. 6 cases of diffuse glioma that presented a diagnostic challenge due to conflicting IDH1/IDH2 (show IDH2 Proteins), ATRX (show ATRX Proteins), and 1p/19q results.

  6. Study indicates IDH1 mutation status was not predictive of 6-month progression free survival or radiographic response in recurrent glioblastoma trials for this data set.

  7. Study demonstrates that patients with IDH1 mutant tumor have significantly higher brain network global efficiency and degree compared to patients with wild type tumor, despite having larger tumor volumes.

  8. In this review, we focus on three key areas in acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) developmental therapeutics: FLT3 (show FLT3 Proteins) inhibitors, IDH(IDH1 and IDH2 (show IDH2 Proteins) ) inhibitors, and drugs that may be particularly beneficial in secondary AML (show RUNX1 Proteins)

  9. The role of mutant IDH1 and IDH2 (show IDH2 Proteins) inhibitors in the treatment of acute myeloid leukemia (show BCL11A Proteins).

  10. Data suggest that identification of IDH1-R132H and ATRX (show ATRX Proteins) loss status in the primary-recurrent gliomas may aid in treatment strategy selection, therapeutic trial design, and clinical prognosis evaluation.

Mouse (Murine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. IDH1 mutations caused down-regulation of leukocyte chemotaxis, resulting in repression of the tumor-associated immune system.

  2. Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagenesis

  3. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC self-renewal, independent of TET2.

  4. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1 (show ACO1 Proteins), enzymes involved in the TCA cycle, were elevated.

  5. data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells

  6. The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

  7. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H.

  8. MiR (show MLXIP Proteins)-181a regulates lipid metabolism via IDH1

  9. revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity.

  10. these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas.

Cow (Bovine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Data suggest that the expression of cytosolic NADP+-dependent isocitrate dehydrogenase in bovine mammary epithelium is modulated by regulators of differentiation including extracellular matrix and lactogenic hormones as well as metabolic effectors.

Pig (Porcine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  3. These results suggest that IDPm (show IDH2 Proteins) plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Proteins) activity.

IDH1 Protein Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Gene names and symbols associated with IDH1

  • isocitrate dehydrogenase (NADP(+)) 1, cytosolic (IDH1)
  • isocitrate dehydrogenase 1 (NADP+), soluble (Idh1)
  • isocitrate dehydrogenase 1 (NADP+) L homeolog (idh1.L)
  • isocitrate dehydrogenase (NADP(+)) 1, cytosolic (Idh1)
  • isocitrate dehydrogenase 1 (NADP+), soluble (idh1)
  • parathyroid hormone 2 receptor (PTH2R)
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2)
  • AI314845 protein
  • AI788952 protein
  • cb876 protein
  • E030024J03Rik protein
  • fm90e09 protein
  • Id-1 protein
  • IDCD protein
  • IDH protein
  • Idh-1 protein
  • IDP protein
  • Idpc protein
  • im:7143416 protein
  • NADP-CICDH protein
  • PICD protein
  • wu:fm90e09 protein

Protein level used designations for IDH1

isocitrate dehydrogenase 1 (NADP+), soluble , isocitrate dehydrogenase [NADP] cytoplasmic-like , NADP(+)-specific ICDH , NADP-dependent isocitrate dehydrogenase, cytosolic , NADP-dependent isocitrate dehydrogenase, peroxisomal , isocitrate dehydrogenase [NADP] cytoplasmic , oxalosuccinate decarboxylase , IDH , IDP , cytosolic NADP-isocitrate dehydrogenase , isocitrate dehydrogenase 1 , Isocitrate dehydrogenase 1, soluble , ICD-M , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase [NADP], mitochondrial

GENE ID SPECIES
478889 Canis lupus familiaris
751618 Felis catus
100414768 Callithrix jacchus
3417 Homo sapiens
15926 Mus musculus
494713 Xenopus laevis
100328559 Oryctolagus cuniculus
24479 Rattus norvegicus
281235 Bos taurus
100006589 Danio rerio
100170146 Sus scrofa
443257 Ovis aries
397603 Sus scrofa
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