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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Proteins (19) and IDH2 Kits (10) and many more products for this protein.
Showing 10 out of 98 products:
Human Monoclonal IDH2 Primary Antibody for IHC (p), ELISA - ABIN396597
Rocquain, Carbuccia, Trouplin, Raynaud, Murati, Nezri, Tadrist, Olschwang, Vey, Birnbaum, Gelsi-Boyer, Mozziconacci: Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias. in BMC cancer 2010
Show all 5 references for ABIN396597
Chicken Polyclonal IDH2 Primary Antibody for WB - ABIN2783282
Shin, Kil, Park: Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. in Biochemical and biophysical research communications 2008
Show all 2 references for ABIN2783282
Human Polyclonal IDH2 Primary Antibody for EIA, WB - ABIN783626
Geisbrecht, Gould: The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. in The Journal of biological chemistry 1999
Human Monoclonal IDH2 Primary Antibody for IHC (p), ELISA - ABIN561418
Gambichler, Terras, Kreuter, Skrygan: Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms. in The British journal of dermatology 2014
Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)
analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)
These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Antibodies) activity.
Leaf IDH activity reduced by 43% in mutant
Identification of DNMT3A and IDH1/IDH2 mutations is instrumental for early detection of acute myeloid leukemia relapse after allogeneic hematopoietic stem cell transplantation.
CASP8 (show CASP8 Antibodies) rs3769823 and IDH2 rs4561444 were as the potential functional variants in high-linkage disequilibrium with these single nucleotide polymorphisms, respectively. The IDH2 mRNA levels were down-regulated in oesophageal squamous cell carcinoma.
Results revealed that the expression of IDH2 was inversely correlated with pathological grade and metastasis in osteosarcoma and its downregulation may exacerbate malignant progression via increased NF-kappaB (show NFKB1 Antibodies) and MMP-9 (show MMP9 Antibodies) activity.
mechanistic studies of IDH2 mutations in gliomas (review)
preclinical studies assessing small molecule inhibitors of mutant IDH1 (show IDH1 Antibodies)/2 enzymes have provided proof of concept that this approach decreases intracellular 2-HG levels, reverses epigenetic dysregulation and induces cellular differentiation
IDH2 mutation is associated with higher risk of malignant transformation in low-grade glioma.
Results show that IDH2 is hypermethylated in glioma and the mutations are mutually exclusive with PTEN (show PTEN Antibodies), P53 (show TP53 Antibodies) and ATRX (show ATRX Antibodies) mutations in the tumors.
Our finding suggests that urinary 2-HG is increased among patients with isocitrate dehydrogenases (IDH1 (show IDH1 Antibodies) and IDH2) -mutant gliomas, and may represent a future surrogate, noninvasive biomarker to aid in diagnosis, prognosis, and management
The Isocitrate dehydrogenase (show IDH1 Antibodies) is mutated at a key active site arginine residue (Arg172 in IDH2) in many cancers, leading to the synthesis of the oncometabolite (R)-2-hydroxyglutarate (2HG).
Down regulation of IDH2 may promote HCC (show FAM126A Antibodies) cell invasion via NF-x03BA;B-dependent increases in MMP9 (show MMP9 Antibodies) activity. IDH2 may be a potential therapeutic target for HCC (show FAM126A Antibodies)
The enzyme is highly sensitive to Mg(2 (show MCOLN1 Antibodies)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 Antibodies)+)] in mitochondrial energy metabolism.
IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.
IDH2 and NPM1 (show GJA1 Antibodies) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Antibodies) stem-like cells.
7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.
These data demonstrate the proto-oncogenic role of mutant IDH2.
The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.
Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (show HIF1A Antibodies) expression, blunted mRNA expression of HIF-1alpha (show HIF1A Antibodies), VEGF (show VEGFA Antibodies), and the glucose transport protein Glut-1 (show SLC1A3 Antibodies) was also observed.
IDH2 mutants can cooperate with oncogenic Flt3 (show FLT3 Antibodies) or Nras (show NRAS Antibodies) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage
SIRT3 (show SIRT3 Antibodies) protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status
Results suggest that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (show IDH1 Antibodies) plays a role in apoptosis induced by high glucose and may contribute to various pathologies associated with the long-term complications of diabetes.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.
isocitrate dehydrogenase 2 (NADP+), mitochondrial
, isocitrate dehydrogenase [NADP], mitochondrial
, isocitrate dehydrogenase [NADP], mitochondrial-like
, NADP(+)-specific ICDH
, oxalosuccinate decarboxylase
, NADP+-specific isocitrate dehydrogenase
, NADPH-specific isocitrate dehydrogenase