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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Proteins (19) and IDH2 Kits (10) and many more products for this protein.
Showing 10 out of 98 products:
Human Monoclonal IDH2 Primary Antibody for IHC (p), ELISA - ABIN396597
Rocquain, Carbuccia, Trouplin, Raynaud, Murati, Nezri, Tadrist, Olschwang, Vey, Birnbaum, Gelsi-Boyer, Mozziconacci: Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias. in BMC cancer 2010
Show all 5 references for ABIN396597
Chicken Polyclonal IDH2 Primary Antibody for WB - ABIN2783282
Shin, Kil, Park: Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. in Biochemical and biophysical research communications 2008
Show all 2 references for ABIN2783282
Human Polyclonal IDH2 Primary Antibody for EIA, WB - ABIN783628
Geisbrecht, Gould: The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. in The Journal of biological chemistry 1999
Human Monoclonal IDH2 Primary Antibody for IHC (p), ELISA - ABIN561418
Gambichler, Terras, Kreuter, Skrygan: Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms. in The British journal of dermatology 2014
Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)
analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)
These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Antibodies) activity.
Leaf IDH activity reduced by 43% in mutant
The Isocitrate dehydrogenase (show IDH1 Antibodies) is mutated at a key active site arginine residue (Arg172 in IDH2) in many cancers, leading to the synthesis of the oncometabolite (R)-2-hydroxyglutarate (2HG).
Down regulation of IDH2 may promote HCC (show FAM126A Antibodies) cell invasion via NF-x03BA;B-dependent increases in MMP9 (show MMP9 Antibodies) activity. IDH2 may be a potential therapeutic target for HCC (show FAM126A Antibodies)
Data show that the monitoring of isocitrate dehydrogenase (NADP(+)) 1/2 IDH1 (show IDH1 Antibodies)/2 mutations showed that these mutations were reliable minimal residual disease (MRD) markers that allowed the prediction of relapse in the majority of patients.
IDH2 mutations are associated with myelodysplastic syndromes.
With the advent of large-scale genome sequencing technology, molecular genetic alterations in IDH2 promoter have now been identified in the majority of oligodendrogliomas
Classification based on IDH1 (show IDH1 Antibodies)/2 mutation status and Ki-67 (show MKI67 Antibodies) expression level could be more convenient for clinical application and guide personalized treatment in malignant gliomas.
The variant allelic frequencies in both IDH1 (show IDH1 Antibodies) and IDH2 were equally low.
transcriptase (TERT (show TERT Antibodies)) promoter mutations may predict enhanced sensitivity to genotoxic therapies in isocitrate dehydrogenase 1 (show IDH1 Antibodies)/2 (IDH1 (show IDH1 Antibodies)/2) wild-type WHO grade II and III diffuse gliomas.
IDH2 mutations and their functions in human tumors (review)
Glioblastomas with IDH1 (show IDH1 Antibodies)-m should be considered a different entity from the IDH1 (show IDH1 Antibodies)-wt, as their natural history and prognosis differ. In the near future we should be classified glioblastomas based on the presence of the IDH1 (show IDH1 Antibodies) mutation
The enzyme is highly sensitive to Mg(2 (show MCOLN1 Antibodies)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 Antibodies)+)] in mitochondrial energy metabolism.
IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.
IDH2 and NPM1 (show GJA1 Antibodies) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Antibodies) stem-like cells.
7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.
These data demonstrate the proto-oncogenic role of mutant IDH2.
The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.
Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (show HIF1A Antibodies) expression, blunted mRNA expression of HIF-1alpha (show HIF1A Antibodies), VEGF (show VEGFA Antibodies), and the glucose transport protein Glut-1 (show SLC1A3 Antibodies) was also observed.
IDH2 mutants can cooperate with oncogenic Flt3 (show FLT3 Antibodies) or Nras (show NRAS Antibodies) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage
SIRT3 (show SIRT3 Antibodies) protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status
Results suggest that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (show IDH1 Antibodies) plays a role in apoptosis induced by high glucose and may contribute to various pathologies associated with the long-term complications of diabetes.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.
isocitrate dehydrogenase 2 (NADP+), mitochondrial
, isocitrate dehydrogenase [NADP], mitochondrial
, isocitrate dehydrogenase [NADP], mitochondrial-like
, NADP(+)-specific ICDH
, oxalosuccinate decarboxylase
, NADP+-specific isocitrate dehydrogenase
, NADPH-specific isocitrate dehydrogenase