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anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Antibodies

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Proteins (19) and IDH2 Kits (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
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Top anti-IDH2 Antibodies at antibodies-online.com

Showing 10 out of 98 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-IDH2 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:12500Positive Control: Human Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of IDH1 in HepG2 cell lysate with IDH1 antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of IDH2 in human heart tissue lysate with IDH2 antibody at (A) 1 and (B) 2 μg/ml. 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to IDH2 on formalin-fixed paraffin-embedded human colon (antibody concentration 3 µg/mL).  Detection limit for recombinant GST tagged IDH2 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- IDH2 Picoband antibody, IHC(P) IHC(P): Rat Intestine Tissue Anti- IDH2 Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Cow Goat Un-conjugated EIA, WB AP22440PU-N IDH1 antibody staining of Human heart lysate at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to IDH2 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml] Detection limit for recombinant GST tagged IDH2 is approximately 0.03ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Goat Un-conjugated IHC (p), ELISA, WB 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of IDH2 expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details

IDH2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-IDH2 Antibodies

  1. Human Monoclonal IDH2 Primary Antibody for IHC (p), ELISA - ABIN396597 : Rocquain, Carbuccia, Trouplin, Raynaud, Murati, Nezri, Tadrist, Olschwang, Vey, Birnbaum, Gelsi-Boyer, Mozziconacci: Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias. in BMC cancer 2010 (PubMed)
    Show all 5 references for ABIN396597

  2. Chicken Polyclonal IDH2 Primary Antibody for WB - ABIN2783282 : Shin, Kil, Park: Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 2 references for ABIN2783282

  3. Human Polyclonal IDH2 Primary Antibody for EIA, WB - ABIN783628 : Geisbrecht, Gould: The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. in The Journal of biological chemistry 1999 (PubMed)

  4. Human Monoclonal IDH2 Primary Antibody for IHC (p), ELISA - ABIN561418 : Gambichler, Terras, Kreuter, Skrygan: Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms. in The British journal of dermatology 2014 (PubMed)

More Antibodies against IDH2 Interaction Partners

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Antibodies) activity.

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Down regulation of IDH2 may promote HCC (show FAM126A Antibodies) cell invasion via NF-x03BA;B-dependent increases in MMP9 (show MMP9 Antibodies) activity. IDH2 may be a potential therapeutic target for HCC (show FAM126A Antibodies)

  2. Data show that the monitoring of isocitrate dehydrogenase (NADP(+)) 1/2 IDH1 (show IDH1 Antibodies)/2 mutations showed that these mutations were reliable minimal residual disease (MRD) markers that allowed the prediction of relapse in the majority of patients.

  3. IDH2 mutations are associated with myelodysplastic syndromes.

  4. With the advent of large-scale genome sequencing technology, molecular genetic alterations in IDH2 promoter have now been identified in the majority of oligodendrogliomas

  5. Classification based on IDH1 (show IDH1 Antibodies)/2 mutation status and Ki-67 (show MKI67 Antibodies) expression level could be more convenient for clinical application and guide personalized treatment in malignant gliomas.

  6. The variant allelic frequencies in both IDH1 (show IDH1 Antibodies) and IDH2 were equally low.

  7. transcriptase (TERT (show TERT Antibodies)) promoter mutations may predict enhanced sensitivity to genotoxic therapies in isocitrate dehydrogenase 1 (show IDH1 Antibodies)/2 (IDH1 (show IDH1 Antibodies)/2) wild-type WHO grade II and III diffuse gliomas.

  8. IDH2 mutations and their functions in human tumors (review)

  9. Glioblastomas with IDH1 (show IDH1 Antibodies)-m should be considered a different entity from the IDH1 (show IDH1 Antibodies)-wt, as their natural history and prognosis differ. In the near future we should be classified glioblastomas based on the presence of the IDH1 (show IDH1 Antibodies) mutation

  10. The IDH2 mutations are associated with improved survival in patients with Glioblastomas.

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. The enzyme is highly sensitive to Mg(2 (show MCOLN1 Antibodies)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 Antibodies)+)] in mitochondrial energy metabolism.

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

  2. IDH2 and NPM1 (show GJA1 Antibodies) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Antibodies) stem-like cells.

  3. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.

  4. These data demonstrate the proto-oncogenic role of mutant IDH2.

  5. The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.

  6. Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (show HIF1A Antibodies) expression, blunted mRNA expression of HIF-1alpha (show HIF1A Antibodies), VEGF (show VEGFA Antibodies), and the glucose transport protein Glut-1 (show SLC1A3 Antibodies) was also observed.

  7. IDH2 mutants can cooperate with oncogenic Flt3 (show FLT3 Antibodies) or Nras (show NRAS Antibodies) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage

  8. SIRT3 (show SIRT3 Antibodies) protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status

  9. Results suggest that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (show IDH1 Antibodies) plays a role in apoptosis induced by high glucose and may contribute to various pathologies associated with the long-term complications of diabetes.

IDH2 Antigen Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Gene names and symbols associated with IDH2

  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2) antibody
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2) antibody
  • Isocitrate dehydrogenase [NAD] regulatory subunit 2 (IDH2) antibody
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2) antibody
  • D2HGA2 antibody
  • E430004F23 antibody
  • F6P23.14 antibody
  • F6P23_14 antibody
  • ICD-M antibody
  • IDH antibody
  • Idh-2 antibody
  • IDH-II antibody
  • IDH2 antibody
  • IDHM antibody
  • IDP antibody
  • IDPm antibody
  • isocitrate dehydrogenase II antibody
  • isocitrate dehydrogenase subunit 2 antibody
  • mNADP-IDH antibody
  • NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 antibody
  • wu:fb33c06 antibody
  • wu:fk31e05 antibody
  • wu:fq43b01 antibody
  • zgc:55485 antibody

Protein level used designations for IDH2

isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like , NADP(+)-specific ICDH , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase

GENE ID SPECIES
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
701480 Macaca mulatta
100155880 Sus scrofa
100441867 Pongo abelii
816218 Arabidopsis thaliana
3418 Homo sapiens
386951 Danio rerio
380013 Xenopus laevis
431056 Gallus gallus
327669 Bos taurus
269951 Mus musculus
361596 Rattus norvegicus
479043 Canis lupus familiaris
397603 Sus scrofa
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