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Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial Proteins (IDH2)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Antibodies (91) and IDH2 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
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Top IDH2 Proteins at antibodies-online.com

Showing 9 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
$2,927.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,147.83
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,147.83
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,147.83
Details
HOST_Sf-9 Cells Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$460.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

IDH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaction Partners

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Proteins) activity.

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Down regulation of IDH2 may promote HCC (show FAM126A Proteins) cell invasion via NF-x03BA;B-dependent increases in MMP9 (show MMP9 Proteins) activity. IDH2 may be a potential therapeutic target for HCC (show FAM126A Proteins)

  2. Data show that the monitoring of isocitrate dehydrogenase (NADP(+)) 1/2 IDH1 (show IDH1 Proteins)/2 mutations showed that these mutations were reliable minimal residual disease (MRD) markers that allowed the prediction of relapse in the majority of patients.

  3. IDH2 mutations are associated with myelodysplastic syndromes.

  4. With the advent of large-scale genome sequencing technology, molecular genetic alterations in IDH2 promoter have now been identified in the majority of oligodendrogliomas

  5. Classification based on IDH1 (show IDH1 Proteins)/2 mutation status and Ki-67 (show MKI67 Proteins) expression level could be more convenient for clinical application and guide personalized treatment in malignant gliomas.

  6. The variant allelic frequencies in both IDH1 (show IDH1 Proteins) and IDH2 were equally low.

  7. transcriptase (TERT (show TERT Proteins)) promoter mutations may predict enhanced sensitivity to genotoxic therapies in isocitrate dehydrogenase 1 (show IDH1 Proteins)/2 (IDH1 (show IDH1 Proteins)/2) wild-type WHO grade II and III diffuse gliomas.

  8. IDH2 mutations and their functions in human tumors (review)

  9. Glioblastomas with IDH1 (show IDH1 Proteins)-m should be considered a different entity from the IDH1 (show IDH1 Proteins)-wt, as their natural history and prognosis differ. In the near future we should be classified glioblastomas based on the presence of the IDH1 (show IDH1 Proteins) mutation

  10. The IDH2 mutations are associated with improved survival in patients with Glioblastomas.

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. The enzyme is highly sensitive to Mg(2 (show MCOLN1 Proteins)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 Proteins)+)] in mitochondrial energy metabolism.

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

  2. IDH2 and NPM1 (show GJA1 Proteins) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Proteins) stem-like cells.

  3. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.

  4. These data demonstrate the proto-oncogenic role of mutant IDH2.

  5. The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.

  6. Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (show HIF1A Proteins) expression, blunted mRNA expression of HIF-1alpha (show HIF1A Proteins), VEGF (show VEGFA Proteins), and the glucose transport protein Glut-1 (show SLC1A3 Proteins) was also observed.

  7. IDH2 mutants can cooperate with oncogenic Flt3 (show FLT3 Proteins) or Nras (show NRAS Proteins) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage

  8. SIRT3 (show SIRT3 Proteins) protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status

  9. Results suggest that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (show IDH1 Proteins) plays a role in apoptosis induced by high glucose and may contribute to various pathologies associated with the long-term complications of diabetes.

IDH2 Protein Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Gene names and symbols associated with IDH2

  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2)
  • Isocitrate dehydrogenase [NAD] regulatory subunit 2 (IDH2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2)
  • D2HGA2 protein
  • E430004F23 protein
  • F6P23.14 protein
  • F6P23_14 protein
  • ICD-M protein
  • IDH protein
  • Idh-2 protein
  • IDH-II protein
  • IDH2 protein
  • IDHM protein
  • IDP protein
  • IDPm protein
  • isocitrate dehydrogenase II protein
  • isocitrate dehydrogenase subunit 2 protein
  • mNADP-IDH protein
  • NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 protein
  • wu:fb33c06 protein
  • wu:fk31e05 protein
  • wu:fq43b01 protein
  • zgc:55485 protein

Protein level used designations for IDH2

isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like , NADP(+)-specific ICDH , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase

GENE ID SPECIES
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
701480 Macaca mulatta
100155880 Sus scrofa
100441867 Pongo abelii
816218 Arabidopsis thaliana
3418 Homo sapiens
386951 Danio rerio
380013 Xenopus laevis
431056 Gallus gallus
327669 Bos taurus
269951 Mus musculus
361596 Rattus norvegicus
479043 Canis lupus familiaris
397603 Sus scrofa
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