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Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial Proteins (IDH2)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Antibodies (99) and IDH2 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
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Top IDH2 Proteins at antibodies-online.com

Showing 9 out of 19 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Arabidopsis thaliana His tag   1 mg Log in to see 56 to 66 Days
$2,927.83
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$3,147.83
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,147.83
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,147.83
Details
HOST_Sf-9 Cells Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$460.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

IDH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaction Partners

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Proteins)

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Proteins) activity.

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. these data suggest that IDH2 may be a tumor suppressor in that its loss may promote malignant progression of gastric cancer via NF-kappaB (show NFKB1 Proteins)-dependent increases in MMP7 (show MMP7 Proteins) activity.

  2. the article summarizes recent progress in understanding of the role of mutations in the genes encoding IDH1 (show IDH1 Proteins) and IDH2 in tumorigenesis (Review)

  3. Genetic variants in IDH2 were found in patients with hematological malignancies.

  4. formylcytosine (5fC) and 5-carboxylcytosine (5caC) levels did not change significantly in these tissues. We further examined the expression levels of IDH1 (show IDH1 Proteins) and IDH2 in gastric cancer tissues and observed that IDH2 levels were significantly lower in gastric cancer tissues than in the adjacent normal tissues

  5. Identification of DNMT3A and IDH1/IDH2 mutations is instrumental for early detection of acute myeloid leukemia relapse after allogeneic hematopoietic stem cell transplantation.

  6. CASP8 (show CASP8 Proteins) rs3769823 and IDH2 rs4561444 were as the potential functional variants in high-linkage disequilibrium with these single nucleotide polymorphisms, respectively. The IDH2 mRNA levels were down-regulated in oesophageal squamous cell carcinoma.

  7. Results revealed that the expression of IDH2 was inversely correlated with pathological grade and metastasis in osteosarcoma and its downregulation may exacerbate malignant progression via increased NF-kappaB (show NFKB1 Proteins) and MMP-9 (show MMP9 Proteins) activity.

  8. mechanistic studies of IDH2 mutations in gliomas (review)

  9. preclinical studies assessing small molecule inhibitors of mutant IDH1 (show IDH1 Proteins)/2 enzymes have provided proof of concept that this approach decreases intracellular 2-HG levels, reverses epigenetic dysregulation and induces cellular differentiation

  10. IDH2 mutation is associated with higher risk of malignant transformation in low-grade glioma.

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. The enzyme is highly sensitive to Mg(2 (show MCOLN1 Proteins)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 Proteins)+)] in mitochondrial energy metabolism.

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

  2. IDH2 and NPM1 (show GJA1 Proteins) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Proteins) stem-like cells.

  3. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.

  4. These data demonstrate the proto-oncogenic role of mutant IDH2.

  5. The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.

  6. Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (show HIF1A Proteins) expression, blunted mRNA expression of HIF-1alpha (show HIF1A Proteins), VEGF (show VEGFA Proteins), and the glucose transport protein Glut-1 (show SLC1A3 Proteins) was also observed.

  7. IDH2 mutants can cooperate with oncogenic Flt3 (show FLT3 Proteins) or Nras (show NRAS Proteins) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage

  8. SIRT3 (show SIRT3 Proteins) protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status

  9. Results suggest that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (show IDH1 Proteins) plays a role in apoptosis induced by high glucose and may contribute to various pathologies associated with the long-term complications of diabetes.

IDH2 Protein Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Gene names and symbols associated with IDH2

  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2)
  • Isocitrate dehydrogenase [NAD] regulatory subunit 2 (IDH2)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2)
  • D2HGA2 protein
  • E430004F23 protein
  • F6P23.14 protein
  • F6P23_14 protein
  • ICD-M protein
  • IDH protein
  • Idh-2 protein
  • IDH-II protein
  • IDH2 protein
  • IDHM protein
  • IDP protein
  • IDPm protein
  • isocitrate dehydrogenase II protein
  • isocitrate dehydrogenase subunit 2 protein
  • mNADP-IDH protein
  • NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 protein
  • wu:fb33c06 protein
  • wu:fk31e05 protein
  • wu:fq43b01 protein
  • zgc:55485 protein

Protein level used designations for IDH2

isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like , NADP(+)-specific ICDH , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase

GENE ID SPECIES
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
701480 Macaca mulatta
100155880 Sus scrofa
100441867 Pongo abelii
816218 Arabidopsis thaliana
3418 Homo sapiens
386951 Danio rerio
380013 Xenopus laevis
431056 Gallus gallus
327669 Bos taurus
269951 Mus musculus
361596 Rattus norvegicus
479043 Canis lupus familiaris
397603 Sus scrofa
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