anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Antibodies

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Proteins (20) and IDH2 Kits (14) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
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Top anti-IDH2 Antibodies at antibodies-online.com

Showing 10 out of 115 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-IDH2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:12500<br><b>Positive Control: </b>Human Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- IDH2 Picoband antibody, IHC(P) IHC(P): Rat Intestine Tissue Anti- IDH2 Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to IDH2 on formalin-fixed paraffin-embedded human colon (antibody concentration 3 µg/mL).  Detection limit for recombinant GST tagged IDH2 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: IDH2 Antibody [NBP1-85784] - Staining of human cell line U-2 OS shows positivity in mitochondria. Western Blot: IDH2 Antibody [NBP1-85784] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: IDH2 Antibody [NBP2-22166] - IDH2 antibody was tested in U2OS cells with DyLight (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). Western Blot: IDH2 Antibody [NBP2-22166] - Western blot analysis of Caki-1 cell lysate (A), human skeletal muscle tissue (B), mouse skeletal muscle tissue (C), and rat skeletal muscle tissue (D) using IDH2 antibody at a concentration of 2 ug/ml. 0.1 mL Log in to see 7 to 9 Days
$381.94
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to IDH2 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml] Detection limit for recombinant GST tagged IDH2 is approximately 0.03ng/ml as a capture antibody. 100 μg Log in to see 11 to 12 Days
$430.00
Details
Human Rabbit Un-conjugated WB Western Blot: IDH2 Antibody [NBP1-54779] - Titration: 0.2-1 ug/ml, Positive Control: Human Muscle. Western Blot: IDH2 Antibody [NBP1-54779] - Middle region validated by WB using Proximal kidney tubules purfied from cortex at 1:1000. 100 μL Log in to see 8 to 11 Days
$447.56
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti IDH2 Polyclonal Antibody, Unconjugated (ABIN751558) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin-embedded lung carcinoma labeled with Anti-IDH2 Polyclonal Antibody, Unconjugated (ABIN751558) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37°C. 100 μL Log in to see 3 to 7 Days
$295.90
Details
Human Rabbit Un-conjugated EIA, WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details

IDH2 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-IDH2 Antibodies

  1. Human Polyclonal IDH2 Primary Antibody for ICC, IF - ABIN4321024 : Saha, Gordan, Kleinstiver, Vu, Najem, Yeo, Shi, Kato, Levin, Webber, Damon, Egan, Greninger, McDermott, Garnett, Jenkins, Rieger-Christ, Sullivan, Hezel, Liss, Mizukami, Goyal, Ferrone, Zhu, Joung et al.: Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. ... in Cancer discovery 2016 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal IDH2 Primary Antibody for ELISA, WB - ABIN4321020 : Abbas, Lugthart, Kavelaars, Schelen, Koenders, Zeilemaker, van Putten, Rijneveld, Löwenberg, Valk: Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. in Blood 2010 (PubMed)

  3. Human Polyclonal IDH2 Primary Antibody for ICC, IF - ABIN4321022 : Murgia, Nagaraj, Deshmukh, Zeiler, Cancellara, Moretti, Reggiani, Schiaffino, Mann: Single muscle fiber proteomics reveals unexpected mitochondrial specialization. in EMBO reports 2015 (PubMed)

  4. Human Polyclonal IDH2 Primary Antibody for WB - ABIN4890344 : Shin, Kil, Park: Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. in Biochemical and biophysical research communications 2008 (PubMed)

  5. Human Monoclonal IDH2 Primary Antibody for IHC (p), ELISA - ABIN561418 : Gambichler, Terras, Kreuter, Skrygan: Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms. in The British journal of dermatology 2014 (PubMed)

  6. Cow (Bovine) Polyclonal IDH2 Primary Antibody for WB - ABIN2783282 : Vohwinkel, Lecuona, Sun, Sommer, Vadász, Chandel, Sznajder: Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation. in The Journal of biological chemistry 2011 (PubMed)
    Show all 2 Pubmed References

More Antibodies against IDH2 Interaction Partners

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Antibodies) activity.

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. IDH (show IDH1 Antibodies) mutations define a distinct subtype of ICC, a malignancy that is largely refractory to current therapies. Our work demonstrates that IDHm ICC cells are hypersensitive to dasatinib and critically dependent on SRC (show SRC Antibodies) activity for survival and proliferation, pointing to new therapeutic strategies against these cancers.

  2. Mutations in the IDH1 (show IDH1 Antibodies) and IDH2 genes perturb the epigenome through cytosine methylation, histone post-translational modifications and transcription factors. [review]

  3. IDH2 mutation is associated with high-grade gliomas.

  4. these results suggest a potential relationship between SIRT3 (show SIRT3 Antibodies) enzymatic activity, IDH2-K413 acetylation-determined dimerization, and a cancer-permissive phenotype

  5. Identification of IDH1 (show IDH1 Antibodies) or IDH2 mutations supports the diagnosis of dedifferentiated chondrosarcoma rather than undifferentiated pleomorphic sarcoma of bone.

  6. There are frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas.

  7. Results showed that TERT promoter mutational status combined with IDH-mutation allowed simple classification of grade II/III gliomas for stratifying patients and clarifying diagnostic accuracy by supplementing standard histopathological criteria.

  8. Results identified IDH2 rs11540478 as a new susceptibility locus for lung cancer.

  9. Functional studies demonstrated that IDH2 and PIK3CA (show PIK3CA Antibodies) hotspot mutations are likely drivers of solid papillary carcinoma with reverse polarity

  10. IDH1 (show IDH1 Antibodies) and IDH2 mutants inhibit TET-promoted oxidation of RNA 5-methylcytosine to 5hydroxymethylcytosine.

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. The enzyme is highly sensitive to Mg(2 (show MCOLN1 Antibodies)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 Antibodies)+)] in mitochondrial energy metabolism.

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) interaction partners

  1. Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.

  2. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

  3. IDH2 and NPM1 (show GJA1 Antibodies) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Antibodies) stem-like cells.

  4. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.

  5. These data demonstrate the proto-oncogenic role of mutant IDH2.

  6. The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.

  7. Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (show HIF1A Antibodies) expression, blunted mRNA expression of HIF-1alpha (show HIF1A Antibodies), VEGF (show VEGFA Antibodies), and the glucose transport protein Glut-1 (show SLC1A3 Antibodies) was also observed.

  8. IDH2 mutants can cooperate with oncogenic Flt3 (show FLT3 Antibodies) or Nras (show NRAS Antibodies) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage

  9. SIRT3 (show SIRT3 Antibodies) protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status

  10. Results suggest that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (show IDH1 Antibodies) plays a role in apoptosis induced by high glucose and may contribute to various pathologies associated with the long-term complications of diabetes.

IDH2 Antigen Profile

Protein Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Gene names and symbols associated with IDH2

  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2) antibody
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2) antibody
  • Isocitrate dehydrogenase [NAD] regulatory subunit 2 (IDH2) antibody
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2) antibody
  • D2HGA2 antibody
  • E430004F23 antibody
  • F6P23.14 antibody
  • F6P23_14 antibody
  • ICD-M antibody
  • IDH antibody
  • Idh-2 antibody
  • IDH-II antibody
  • IDH2 antibody
  • IDHM antibody
  • IDP antibody
  • IDPm antibody
  • isocitrate dehydrogenase II antibody
  • isocitrate dehydrogenase subunit 2 antibody
  • mNADP-IDH antibody
  • NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 antibody
  • wu:fb33c06 antibody
  • wu:fk31e05 antibody
  • wu:fq43b01 antibody
  • zgc:55485 antibody

Protein level used designations for IDH2

isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like , NADP(+)-specific ICDH , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase

GENE ID SPECIES
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
701480 Macaca mulatta
100155880 Sus scrofa
100441867 Pongo abelii
816218 Arabidopsis thaliana
3418 Homo sapiens
386951 Danio rerio
380013 Xenopus laevis
431056 Gallus gallus
327669 Bos taurus
269951 Mus musculus
361596 Rattus norvegicus
479043 Canis lupus familiaris
397603 Sus scrofa
Selected quality suppliers for anti-IDH2 (IDH2) Antibodies
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