Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Additionally we are shipping IDH2 Proteins (20) and IDH2 Kits (12) and many more products for this protein.
Showing 10 out of 98 products:
Human Monoclonal IDH2 Primary Antibody for IHC (p), ELISA - ABIN396597
Rocquain, Carbuccia, Trouplin, Raynaud, Murati, Nezri, Tadrist, Olschwang, Vey, Birnbaum, Gelsi-Boyer, Mozziconacci: Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias. in BMC cancer 2010
Show all 5 references for ABIN396597
Human Polyclonal IDH2 Primary Antibody for ICC, IF - ABIN4321024
Saha, Gordan, Kleinstiver, Vu, Najem, Yeo, Shi, Kato, Levin, Webber, Damon, Egan, Greninger, McDermott, Garnett, Jenkins, Rieger-Christ, Sullivan, Hezel, Liss, Mizukami, Goyal, Ferrone, Zhu, Joung et al.: Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. ... in Cancer discovery 2016
Show all 2 references for ABIN4321024
Chicken Polyclonal IDH2 Primary Antibody for WB - ABIN2783282
Shin, Kil, Park: Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. in Biochemical and biophysical research communications 2008
Show all 2 references for ABIN2783282
Human Monoclonal IDH2 Primary Antibody for IHC (p), ELISA - ABIN561418
Gambichler, Terras, Kreuter, Skrygan: Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms. in The British journal of dermatology 2014
Human Polyclonal IDH2 Primary Antibody for ICC, IF - ABIN4321022
Murgia, Nagaraj, Deshmukh, Zeiler, Cancellara, Moretti, Reggiani, Schiaffino, Mann: Single muscle fiber proteomics reveals unexpected mitochondrial specialization. in EMBO reports 2015
Human Polyclonal IDH2 Primary Antibody for EIA, WB - ABIN783626
Geisbrecht, Gould: The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase. in The Journal of biological chemistry 1999
Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)
analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (show IDH3B Antibodies)
These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (show GRX1 Antibodies) activity.
Leaf IDH activity reduced by 43% in mutant
A total of 152 deficient DNA mismatch repair system (dMMR) of colorectal cancers (CRCs) patients were analyzed. No IDH (show IDH1 Antibodies) mutation was observed in dMMR CRC (show CALR Antibodies), nor in IDH1 (show IDH1 Antibodies) or IDH2. Especially, no mutation was found in sporadic dMMR CRC (show CALR Antibodies) which is known to be associated with CpG island methylator phenotype.
the contribution of IDH1 (show IDH1 Antibodies) and IDH2 mutations to gliomagenesis[review]
Only three IDH2(R172) mutation cases were detected in this series of patients with astrocytomas and oligodendrogliomas
review examines mutant IDH1 (show IDH1 Antibodies)/2 and TET2 (show TET2 Antibodies) enzymes in the context of responses to DNA damage and their potential involvement in age-related genomic instability.
The study confirmed the importance of the IDH1 (show IDH1 Antibodies)/2 mutation and hypermethylation of the MGMT (show MGMT Antibodies) gene promoter being present in brain Glioma tissue.
these data suggest that IDH2 may be a tumor suppressor in that its loss may promote malignant progression of gastric cancer via NF-kappaB (show NFKB1 Antibodies)-dependent increases in MMP7 (show MMP7 Antibodies) activity.
the article summarizes recent progress in understanding of the role of mutations in the genes encoding IDH1 (show IDH1 Antibodies) and IDH2 in tumorigenesis (Review)
Genetic variants in IDH2 were found in patients with hematological malignancies.
formylcytosine (5fC) and 5-carboxylcytosine (5caC) levels did not change significantly in these tissues. We further examined the expression levels of IDH1 (show IDH1 Antibodies) and IDH2 in gastric cancer tissues and observed that IDH2 levels were significantly lower in gastric cancer tissues than in the adjacent normal tissues
Identification of DNMT3A and IDH1/IDH2 mutations is instrumental for early detection of acute myeloid leukemia relapse after allogeneic hematopoietic stem cell transplantation.
The enzyme is highly sensitive to Mg(2 (show MCOLN1 Antibodies)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (show MCOLN1 Antibodies)+)] in mitochondrial energy metabolism.
Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.
IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.
IDH2 and NPM1 (show GJA1 Antibodies) mutations synergize in the development and maintenance of acute myeloid leukemia (show BCL11A Antibodies) stem-like cells.
7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.
These data demonstrate the proto-oncogenic role of mutant IDH2.
The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.
Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (show HIF1A Antibodies) expression, blunted mRNA expression of HIF-1alpha (show HIF1A Antibodies), VEGF (show VEGFA Antibodies), and the glucose transport protein Glut-1 (show SLC1A3 Antibodies) was also observed.
IDH2 mutants can cooperate with oncogenic Flt3 (show FLT3 Antibodies) or Nras (show NRAS Antibodies) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage
SIRT3 (show SIRT3 Antibodies) protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status
Results suggest that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (show IDH1 Antibodies) plays a role in apoptosis induced by high glucose and may contribute to various pathologies associated with the long-term complications of diabetes.
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.
isocitrate dehydrogenase 2 (NADP+), mitochondrial
, isocitrate dehydrogenase [NADP], mitochondrial
, isocitrate dehydrogenase [NADP], mitochondrial-like
, NADP(+)-specific ICDH
, oxalosuccinate decarboxylase
, NADP+-specific isocitrate dehydrogenase
, NADPH-specific isocitrate dehydrogenase