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Isoprenylcysteine Carboxyl Methyltransferase Proteins (ICMT)

ICMT encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. Additionally we are shipping Isoprenylcysteine Carboxyl Methyltransferase Antibodies (47) and Isoprenylcysteine Carboxyl Methyltransferase Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ICMT 23463 O60725
ICMT 57295 Q9EQK7
Rat ICMT ICMT 170818  
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Top Isoprenylcysteine Carboxyl Methyltransferase Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$322.14
Details

ICMT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Top referenced Isoprenylcysteine Carboxyl Methyltransferase Proteins

  1. Human ICMT Protein expressed in Escherichia coli (E. coli) - ABIN667011 : Kagan, McFadden, McFadden, OConnor, Clarke: Molecular phylogenetics of a protein repair methyltransferase. in Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1997 (PubMed)

More Proteins for Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Interaction Partners

Human Isoprenylcysteine Carboxyl Methyltransferase (ICMT) interaction partners

  1. simultaneous inhibition of BCR-ABL1 and Icmt may represent a potential therapeutic strategy for CML.

  2. impact of Icmt on tumorigenic processes

  3. Silencing ICMT in osteosarcoma cells decreas (show NOTCH1 Proteins)ed Notch1 signaling in (show PDX1 Proteins)response to stimulation with cell-surface ligands.

  4. a role for isoprenylcysteine carboxylmethyltransferase in cell migration and adhesion.

  5. modulation of pcCMT activity in retinoic acid (RA)-treated SH-SY5Y neuroblastoma (show ARHGEF16 Proteins) cells

  6. ICMTase is a critical component of the redox-sensitive VCAM-1-selective signaling pathway and appears to activate a discrete inflammatory signaling pathway, at least in part, through the methylation of Rac1 in endothelial cells.

  7. findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase (show RACGAP1 Proteins) methylation and activation and its downstream antiapoptotic signaling pathway.

  8. These studies identify isoprenylcysteine carboxyl methyltransferase as a potential target for reducing the growth of K-Ras (show HRAS Proteins)- and B-Raf (show SNRPE Proteins)-induced malignancies.

  9. ICMT inhibition induces endothelial cell apoptosis through GRP94 (show HSP90B1 Proteins)

  10. Icmt traverses the Eendoplasmic reticulum membrane eight times, with both N and C termini disposed toward the cytosol and with a helix-turn-helix structure comprising transmembrane (TM) segments 7 and 8.

Mouse (Murine) Isoprenylcysteine Carboxyl Methyltransferase (ICMT) interaction partners

  1. simultaneous inhibition of BCR-ABL1 and Icmt may represent a potential therapeutic strategy for CML.

  2. ICMT deficiency precisely phenocopied Notch1 (show NOTCH1 Proteins) deficiency in the Pdx1 (show PDX1 Proteins)-Cre;LSL-KrasG12D model by exacerbating pancreatic intraepithelial neoplasias, promoting facial papillomas, and derepressing Wnt (show WNT2 Proteins) signaling.

  3. findings suggest that inhibition of isoprenylcysteine-O-carboxyl methyltransferase (ICMT) causes endothelial cell apoptosis by attenuation of Ras GTPase (show RACGAP1 Proteins) methylation and activation and its downstream antiapoptotic signaling pathway.

  4. inactivating Icmt reduced splenomegaly, the number of immature myeloid cells in peripheral blood, tissue infiltration by myeloid cells, reduced lung tumor development and myeloproliferation phenotypes in a mouse model of K-RAS-induced cancer.

Cow (Bovine) Isoprenylcysteine Carboxyl Methyltransferase (ICMT) interaction partners

  1. ICMT inhibition induces endothelial cell apoptosis through GRP94 (show HSP90B1 Proteins)

Isoprenylcysteine Carboxyl Methyltransferase (ICMT) Protein Profile

Protein Summary

This gene encodes the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. This enzyme localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined.

Gene names and symbols associated with ICMT

  • isoprenylcysteine carboxyl methyltransferase (icmt)
  • isoprenylcysteine carboxyl methyltransferase (Bcen_5417)
  • isoprenylcysteine carboxyl methyltransferase (Acid_0983)
  • isoprenylcysteine carboxyl methyltransferase (Bcenmc03_4825)
  • Isoprenylcysteine carboxyl methyltransferase (Rpic_1767)
  • Isoprenylcysteine carboxyl methyltransferase (Mesil_1887)
  • Isoprenylcysteine carboxyl methyltransferase (Slip_1333)
  • Isoprenylcysteine carboxyl methyltransferase (Deba_2487)
  • Isoprenylcysteine carboxyl methyltransferase (Bresu_2161)
  • isoprenylcysteine carboxyl methyltransferase (Mpet_0933)
  • isoprenylcysteine carboxyl methyltransferase (Mpet_1639)
  • Isoprenylcysteine carboxyl methyltransferase (Saut_0066)
  • isoprenylcysteine carboxyl methyltransferase (Intca_3523)
  • isoprenylcysteine carboxyl methyltransferase (Deima_2891)
  • Isoprenylcysteine carboxyl methyltransferase (Despr_1203)
  • Isoprenylcysteine carboxyl methyltransferase (Deipr_0831)
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_2650)
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_3385)
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_3501)
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_4056)
  • Isoprenylcysteine carboxyl methyltransferase (Mesop_4939)
  • Isoprenylcysteine carboxyl methyltransferase (Theth_0229)
  • isoprenylcysteine carboxyl methyltransferase (ICMT)
  • isoprenylcysteine carboxyl methyltransferase (Icmt)
  • 1700008E11Rik protein
  • C80758 protein
  • fcmt protein
  • Gm13095 protein
  • HSTE14 protein
  • im:6895697 protein
  • MST098 protein
  • MSTP098 protein
  • OTTMUSG00000010406 protein
  • pcCMT protein
  • PCMT protein
  • PPMT protein
  • STE14 protein
  • zgc:110258 protein

Protein level used designations for ICMT

protein-S-isoprenylcysteine O-methyltransferase , isoprenylcysteine carboxyl methyltransferase , Isoprenylcysteine carboxyl methyltransferase , prenylated protein carboxyl methyltransferase , prenylcysteine carboxyl methyltransferase , protein-S isoprenylcysteine O-methyltransferase , FCMT , PPMT , farnesyl cysteine carboxyl methyltransferase , pcCMT , prenylcysteine carboxyl methlytransferase

GENE ID SPECIES
550281 Danio rerio
4094605 Burkholderia cenocepacia AU 1054
4430863 Candidatus Solibacter usitatus Ellin6076
6127637 Burkholderia cenocepacia MC0-3
6287318 Ralstonia pickettii 12J
9251399 Meiothermus silvanus DSM 9946
9274122 Syntrophothermus lipocalidus DSM 12680
9494959 Desulfarculus baarsii DSM 2075
9504035 Brevundimonas subvibrioides ATCC 15264
9743393 Methanoplanus petrolearius DSM 11571
9744111 Methanoplanus petrolearius DSM 11571
9757577 Sulfurimonas autotrophica DSM 16294
10086362 Intrasporangium calvum DSM 43043
10152256 Deinococcus maricopensis DSM 21211
10173921 Desulfobulbus propionicus DSM 2032
10256310 Deinococcus proteolyticus MRP
10826487 Mesorhizobium opportunistum WSM2075
10827223 Mesorhizobium opportunistum WSM2075
10827339 Mesorhizobium opportunistum WSM2075
10827904 Mesorhizobium opportunistum WSM2075
10828798 Mesorhizobium opportunistum WSM2075
10884973 Thermotoga thermarum DSM 5069
23463 Homo sapiens
397717 Xenopus laevis
419373 Gallus gallus
489628 Canis lupus familiaris
57295 Mus musculus
170818 Rattus norvegicus
100514410 Sus scrofa
785548 Bos taurus
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