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JAZF1 encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Additionally we are shipping JAZF Zinc Finger 1 Antibodies (24) and JAZF Zinc Finger 1 Kits (3) and many more products for this protein.
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study found SNP rs7754840 in CDKAL1 (show CDKAL1 Proteins), rs864745 in JAZF1, and rs35767 in IGF1 (show IGF1 Proteins) might serve as potential susceptibility loci for type 2 diabetes in the Uyghur population
genetic association study in Han population in China: Data suggest an SNP in PXK (show PXK Proteins) [rs2176082(C/T); but not rs6445975(G/T)] is associated with recurrent pregnancy loss; SNPs in KIAA0319L (show KIAA0319L Proteins) [rs2275247(A/G)] or JAZF1 [rs1635852(C/T)] are not associated.
In African American men, the association between JAZF1 rs10486567 and prostate cancer may be modified by exposure to heavy metals such as Pb.
study determined that the previously described systemic lupus erythematosus susceptibility loci PXK (show PXK Proteins) (P = 3.27 x 10(-11), OR = 1.20) and JAZF1 (P = 1.11 x 10(-8), OR = 1.13) are shared with systemic sclerosis
Morphological features, immunoprofile and fluorescence in situ hybridization rearrangements of JAZF1 and PHF1 (show PHF1 Proteins) genes were correlated with tumor category and outcome in endometrial sarcomas
genetic association studies in a population in Utah: Data suggest that an SNP in JAZF1 (rs1635852) is associated with type 2 diabetes; this SNP in JAZF1 intron 1 is part of a cis (show CISH Proteins)-regulatory complex.
This study indicates a nominal role for JAZF1 and BCL11A (show BCL11A Proteins) variants in type 2 diabetes susceptibility in African-Americans.
Single-nucleotide polymorphism of rs10486567 in JAZF1 is associated with prostate cancer.
The JAZF1 SNPs rs6968704 and rs10486567 were associated with decreased risk of prostate cancer but were not associated with diabetes.
Endometrial stromal tumors(ESTs) are genetically heterogeneous, with prevalence of JAZF1-JJAZ1 (show SUZ12 Proteins) fusion highest among ESTs of classic histology. Diagnostic utility of JAZF1-JJAZ1 (show SUZ12 Proteins) fusion transcript assay in ESTs may be limited to classic histologic subset.
TIP27 has an important role in glucose homeostasis through the regulation of hepatic glucose metabolism and insulin (show INS Proteins) sensitivity. Furthermore, this regulation requires activation of PI3-kinase (show PIK3CA Proteins).
aberrant JAZF1 expression contributes to the oncogenesis and type 2 diabetes pathogenesis
JAZF1 overexpression decreased serum cholesterol levels and hepatic cholesterol synthesis by inhibiting CREB (show CREB1 Proteins)-dependent HMGCR (show HMGCR Proteins) promoter transcriptional activity.
JAZF1 plays an important role in lipid metabolism and may thus provide a potential tool for the treatment of obesity and lipid metabolism disorders among other diseases
JAZF1 was significantly upregulated during the differentiation of 3T3-L1 preadipocytes. The overexpression of JAZF1 inhibited lipid accumulation in differentiated mature 3T3-L1 adipocytes.
results suggest that Jazf1 plays a critical role in the regulation of lipid homeostasis. Finally, Jazf1 may provide a new therapeutic target in the management of obesity and diabetes
Jazf1 overexpression may induce heart failure symptoms through the upregulation of pro-apoptotic genes in cardiomyocytes.
These results showed that JAZF1 in adipocytes and liver cells reduces lipid synthesis and increases lipolysis
This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized
JAZF zinc finger 1
, juxtaposed with another zinc finger gene 1
, juxtaposed with another zinc finger protein 1
, TAK1-interacting protein 27
, zinc finger protein 802