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JRK is the human homolog of the mouse jerky gene. Additionally we are shipping JRK Antibodies (4) and many more products for this protein.
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JRK (show CLOCK Proteins) expression was aberrantly elevated in 21% of colorectal cancers, 15% of breast and ovarian cancers and was associated with increased expression of beta-catenin (show CTNNB1 Proteins) target genes and increased cell proliferation
in the adult intestine, Ebd (show DEFB1 Proteins) acts independently of Ewg in physiological Wnt (show WNT2 Proteins) signaling, but cooperates with Ewg to induce the hyperactivation of Wnt (show WNT2 Proteins) target gene expression following Apc1 (show SLC25A24 Proteins) loss. These findings have relevance for human tumorigenesis, as Jerky (JRK/JH8), the human Ebd (show DEFB1 Proteins) homolog, promotes Wnt (show WNT2 Proteins) pathway hyperactivation and is overexpressed in colorectal, breast, and ovarian cancers
Jerky has a role in epilepsy and consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs
JRK protein associates with a specific chromosomal centromeric locus in the cell cycle G(2) phase.
This gene is the human homolog of the mouse jerky gene. The encoded protein has similarity to several nuclear regulatory proteins, including centromere protein B, suggesting that it might function as a DNA-binding protein. Insertional inactivation of this gene in transgenic mice resulted in epileptic seizures. Childhood Absence Epilepsy (CAE) has been mapped to the same chromosomal location (8q24.3) as this gene, making this gene a strong candidate for CAE. Two transcript variants encoding different isoforms have been found for this gene.
jerky protein homolog
, jerky protein