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The function of JRKL has not yet been defined, however, the encoded protein shares similarity with the human (41% identical) and mouse (34% identical) jerky gene products. Additionally we are shipping Jerky Homolog-Like (Mouse) Proteins (3) and many more products for this protein.
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JRK (show CLOCK Antibodies) expression was aberrantly elevated in 21% of colorectal cancers, 15% of breast and ovarian cancers and was associated with increased expression of beta-catenin (show CTNNB1 Antibodies) target genes and increased cell proliferation
in the adult intestine, Ebd (show DEFB1 Antibodies) acts independently of Ewg in physiological Wnt (show WNT2 Antibodies) signaling, but cooperates with Ewg to induce the hyperactivation of Wnt (show WNT2 Antibodies) target gene expression following Apc1 (show SLC25A24 Antibodies) loss. These findings have relevance for human tumorigenesis, as Jerky (JRK (show JRK Antibodies)/JH8), the human Ebd (show DEFB1 Antibodies) homolog, promotes Wnt (show WNT2 Antibodies) pathway hyperactivation and is overexpressed in colorectal, breast, and ovarian cancers
The function of this gene has not yet been defined, however, the encoded protein shares similarity with the human (41% identical) and mouse (34% identical) jerky gene products. This protein may act as a nuclear regulatory protein. Alternatively spliced transcript variants have been found for this gene.
jerky protein homolog-like
, jerky protein homolog
, human homolog of mouse jerky gene protein