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JMJD6 encodes a nuclear protein with a JmjC domain. Additionally we are shipping Jumonji Domain Containing 6 Proteins (10) and Jumonji Domain Containing 6 Kits (5) and many more products for this protein.
Showing 10 out of 115 products:
Human Polyclonal JMJD6 Primary Antibody for WB - ABIN658081
Hong, Zang, White, Wang, Pan, Zhao, Murphy, Dai, Henson, Kappler, Hagman, Zhang: Interaction of JMJD6 with single-stranded RNA. in Proceedings of the National Academy of Sciences of the United States of America 2010
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Cow (Bovine) Polyclonal JMJD6 Primary Antibody for WB - ABIN2780968
Cao, Kambe, Moeller, Refetoff, Seo: Thyroid hormone induces rapid activation of Akt/protein kinase B-mammalian target of rapamycin-p70S6K cascade through phosphatidylinositol 3-kinase in human fibroblasts. in Molecular endocrinology (Baltimore, Md.) 2004
Show all 2 references for 2780968
Human Polyclonal JMJD6 Primary Antibody for EIA, WB - ABIN356578
Vandivier, Fadok, Hoffmann, Bratton, Penvari, Brown, Brain, Accurso, Henson: Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. in The Journal of clinical investigation 2002
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Cow (Bovine) Polyclonal JMJD6 Primary Antibody for IHC, WB - ABIN2777439
Cao, Murao, Imachi, Hiramine, Abe, Yu, Dobashi, Wong, Takahara, Ishida: Phosphatidylserine receptor cooperates with high-density lipoprotein receptor in recognition of apoptotic cells by thymic nurse cells. in Journal of molecular endocrinology 2004
Show all 2 references for 2777439
Human Monoclonal JMJD6 Primary Antibody for ICC - ABIN1742540
Hahn, Wegener, Burrells, Böse, Wolf, Erck, Butler, Schofield, Böttger, Lengeling: Analysis of Jmjd6 cellular localization and testing for its involvement in histone demethylation. in PLoS ONE 2010
Human Polyclonal JMJD6 Primary Antibody for WB - ABIN387893
Fadok, Bratton, Rose, Pearson, Ezekewitz, Henson: A receptor for phosphatidylserine-specific clearance of apoptotic cells. in Nature 2000
Cow (Bovine) Polyclonal JMJD6 Primary Antibody for WB - ABIN2780967
Chang, Chen, Zhao, Bruick: JMJD6 is a histone arginine demethylase. in Science (New York, N.Y.) 2007
JMJD6 regulated a large set of alternative splicing events, and importantly, its regulated splicing events were significantly overlapped those controlled by U2AF65 (show U2AF59 Antibodies).
AcK27-HOXB9 (show HOXB9 Antibodies) suppresses the transcription of its target gene Jumonji domain-containing protein 6 (JMJD6) by direct occupying the promoter of JMJD6 gene.
These findings provide evidence that JMJD6 may play a role in regulating the production of sFLT-1 in the preeclamptic placenta. Decreased placental JMJD6 expression may be an important component to the pathophysiology of preeclampsia.
Study identified a novel epigenetic mechanism showing how JMJD6 cooperates with Myc (show MYC Antibodies) during oncogenic transformation. Combined high expression of Myc (show MYC Antibodies) and JMJD6 confers a more aggressive phenotype in mouse and human tumors.
Our studies identify JMJD6 as a molecular determinant of cancer stem cell phenotype
Although JMJD6 displays anti-tumoral properties in cell lines, its expression in breast tumours may be a marker of poor prognosis, suggesting that its function could be altered in breast cancer
The expression of JMJD6 was reduced in T lymphocytes in chronic hepatitis B.
A novel role for JMJD6 as an oxygen sensor in the human placenta, and alterations in the JMJD6-VHL (show VHL Antibodies)-HIF1A (show HIF1A Antibodies) feedback loop may indirectly contribute to elevated HIF1A (show HIF1A Antibodies) found in preeclampsia.
JMJD6 is a potential biomarker for colon cancer aggressiveness and a potential target for colon cancer intervention.
Study reports that a unique cohort of JMJD6 and Brd4 (show BRD4 Antibodies) cobound distal enhancers, termed anti-pause enhancers, regulate promoter-proximal pause release of a large subset of transcription units via long-range interactions.
Although Jmjd6 deficiency does not affect abundance of Aire (show AIRE Antibodies) transcript, the intron 2 of Aire (show AIRE Antibodies) gene is not effectively spliced out in the absence of Jmjd6, resulting in reduction of mature Aire (show AIRE Antibodies) protein and spontaneous multi-organ autoimmunity in mice.
The results indicate dual roles for JMJD6 in promoting adipogenic gene expression program by post-transcriptional regulation of C/EBPbeta (show CEBPB Antibodies) and C/EBPdelta (show CEBPD Antibodies) and direct transcriptional activation of Ppargamma2 (show PPARG Antibodies) and Cebpalpha during adipocyte differentiation.
histones are additional substrates of JMJD6 in vivo. Because 5-hydroxylation of lysyl residues inhibited N-acetylation and N-methylation by an acetyltransferase and a methyltransferase
confirmed that Jmjd6 forms multimers and showed that nuclear localization of the protein involves association with a nucleic acid matrix
protein kinase C beta (show PRKCB Antibodies) activation is dependent upon phosphatidylserine receptor action
data demonstrate a critical role for PSR in early stages of mammalian organogenesis and suggest that this receptor may be involved in respiratory distress syndromes and congenital brain malformations
during embryonic development, phosphatidylserine receptor-mediated apoptotic cell uptake is required for definitive erythropoiesis and T lymphopoiesis, independently of the prevention of inflammatory responses
Ptdsr is localized in the cell nucleus via multiple nuclear localization signals.
Ptdsr is essential for the development and differentiation of multiple organs during embryogenesis but not for apoptotic cell clearance.
identified cardiac malformations in Ptdsr deficient embryos, including ventricular septal defects, double-outlet right ventricle, and hypoplasia of the pulmonary artery and thymus.
results suggest that YY1a (show YY1 Antibodies) regulates PS receptor expression that linked to function of PSR-phagocyte mediated apoptotic cell engulfment during development
PSR-dependent system in zebrafish embryos that engulfs apoptotic cells mediated by PSR-phagocytes during development, with the system assuming an important role in the normal development of tissues such as the brain, heart, notochord and somite
JMJD6 contributes to foot-and-mouth disease virus infectivity and may be a previously unidentified foot-and-mouth disease receptor.
Demethylated RHA bound JMJD6 monomer during foot-and-mouth disease virus infection.
This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells\; however, subsequent studies have indicated that it does not directly function in the clearance of apoptotic cells, and questioned whether it is a true phosphatidylserine receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
jumonji domain containing 6
, phosphatidylserine receptor
, Histone arginine demethylase JMJD6
, bifunctional arginine demethylase and lysyl-hydroxylase JMJD6
, jmjC domain-containing protein 6
, jumonji domain-containing protein 6
, lysyl-hydroxylase JMJD6
, peptide-lysine 5-dioxygenase JMJD6
, histone arginine demethylase JMJD6
, apoptotic cell clearance receptor PtdSerR
, bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-A
, histone arginine demethylase JMJD6-A
, jmjC domain-containing protein 6-A
, jumonji domain-containing protein 6-A
, lysyl-hydroxylase JMJD6-A
, peptide-lysine 5-dioxygenase JMJD6-A
, phosphatidylserine receptor-A
, protein PTDSR-A
, bifunctional arginine demethylase and lysyl-hydroxylase JMJD6-B
, histone arginine demethylase JMJD6-B
, jmjC domain-containing protein 6-B
, jumonji domain-containing protein 6-B
, lysyl-hydroxylase JMJD6-B
, peptide-lysine 5-dioxygenase JMJD6-B
, phosphatidylserine receptor-B
, protein PTDSR-B
, protein PTDSR