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The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. Additionally we are shipping Jun D Proto-Oncogene Kits (10) and Jun D Proto-Oncogene Proteins (8) and many more products for this protein.
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identify AP-1(JunD/c-Fos) as a novel hematopoietic transcription factor and the requirement of AP-1(JunD/c-Fos) in BMP-4 (show BMP4 Antibodies)-induced hematopoiesis during Xenopus hematopoiesis.
Data indicate the mechanism underlying redox-regulation of AP-1 Fos/Jun transcription factors and suggest structural insight for therapeutic interventions targeting AP-1 proteins.
In T cells, after serum deprivation HBZ (show HBZ Antibodies) induces the expression of Delta JunD isoform. Unlike JunD, Delta JunD induces proliferation and transformation of cells. HBZ (show HBZ Antibodies) bypasses translational control of JunD uORF and favors the expression of Delta JunD. The truncated isoform Delta JunD has a central role in the oncogenic process leading to adult T-cell leukemia .
MiR (show MLXIP Antibodies)-663a suppresses proliferation and invasion by targeting AP-1 (show FOSB Antibodies) component JunD in non-small cell lung cancer cells.
studies showed that down-regulation of JunD in response to TGF-beta (show TGFB1 Antibodies) treatment is mediated via the proteasomal degradation pathway.
CARMA1 (show CARD11 Antibodies)- and MyD88 (show MYD88 Antibodies)-dependent activation of Jun (show JUN Antibodies)/ATF-type AP-1 (show FOSB Antibodies) complexes is a hallmark of ABC (show ABCB6 Antibodies) diffuse large B-cell lymphomas.
recombinant SERPINE2 (show SERPINE2 Antibodies) induced a clear inhibition of MMP-13 (show MMP13 Antibodies) expression in IL-1alpha-stimulated chondrocytes. This inhibitory effect is likely regulated through a pathway involving ERK 1 (show MAPK3 Antibodies)/2, NF-kappaB (show NFKB1 Antibodies) and AP-1 (show FOSB Antibodies)
miR (show MLXIP Antibodies)-494 is a novel regulator of HNPC apoptosis induced by TNF-alpha (show TNF Antibodies)
JunD activates miR (show MLXIP Antibodies)-29b by enhancing its transcription and processing, which contribute to the inhibitory effect of JunD
Binding of specific AP-1 (show FOSB Antibodies) factors, we found JunD associated with the LILRB1 (show LILRB1 Antibodies) distal promoter.
Cells in contact with basement membrane undergo transient oscillations between two molecular states defined by their TGFBR3 (show TGFBR3 Antibodies)- JUND expression.
The present data indicate that bovine dialyzable leukocyte extract can block the AP-1 (show JUN Antibodies) DNA-binding activity and expression of several transcriptions factors in breast cancer cells.
Differentiation-mediated activation of JunD results in enhanced TUBB4a (show TUBB5 Antibodies) expression in P19 (show CDKN2D Antibodies) embryonal carcinoma cells.
JunD provides protection in aging-induced endothelial dysfunction and may represent a novel target to prevent reactive oxygen species-driven vascular aging.
AP-1 (show JUN Antibodies) composed with JunD and Fra2 (show FOSL2 Antibodies) protein plays a primary role in enhancing the transcription level of the CD11c (show ITGAX Antibodies) gene in dendritic cells
Nfe2 (show NFE2 Antibodies) modulates JunD binding to the Gcm1 (show GCM1 Antibodies) promoter via acetylation
5-HT2B (show HTR2B Antibodies) blockade enhances liver regeneration by inhibiting induction of TGF-beta1 (show TGFB1 Antibodies) expression by hepatic stellate cells that is dependent on 5-HT (show DDC Antibodies), ERK (show EPHB2 Antibodies) and JunD.
CDK4 (show CDK4 Antibodies)-mediated regulation of cell functions via c-Jun (show JUN Antibodies) phosphorylation and AP-1 (show JUN Antibodies) activation
Downregulation of JunD and cyclin D1 (show CCND1 Antibodies) expression in myofibroblasts may be important regarding the mechanism of action of MTA (show DNMT1 Antibodies) in Mdr2 (show ABCB4 Antibodies)-/- mice
c-Jun (show JUN Antibodies), JunB (show JUNB Antibodies), and JunD are not functionally equivalent and have both overlapping and independent functions in controlling cellular proliferation, cell-cycle arrest/senescence and the response to stress.
Study supports potential roles for jun (show JUN Antibodies) D, jun (show JUN Antibodies) B, and fra-1 (show FOSL1 Antibodies) in the dietary energy restriction regulation of AP-1 (show JUN Antibodies) function in the Sencar mouse skin carcinogenesis model.
protects cells from p53 (show TP53 Antibodies)-dependent senescence and apoptosis
The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. It has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternate translation initiation site usage, including non-AUG codons, results in the production of different isoforms.
transcription factor jun-D
, JunD-FL isoform
, activator protein 1
, Jun proto-oncogene related gene d1